The 5-heterofunctionalized triazoles are important scaffolds in bioactive compounds, but current click reactions (CuAAC) cannot produce these core structures. A copper(I)-catalyzed interrupted click reaction to access diverse 5-functionalized triazoles is reported. Various 5-amino-, thio-, and selenotriazoles were readily assembled in one step in high yields. The reaction proceeds under mild conditions with complete regioselectivity. It also features a broad substrate scope and good functional group compatibility.

The 5-heterofunctionalized triazoles are important scaffolds in bioactive compounds, but current click reactions (CuAAC) cannot produce these core structures. A copper(I)-catalyzed interrupted click reaction to access diverse 5-functionalized triazoles is reported. Various 5-amino-, thio-, and selenotriazoles were readily assembled in one step in high yields. The reaction proceeds under mild conditions with complete regioselectivity. It also features a broad substrate scope and good functional group compatibility.

Recently, homogeneous gold catalysis has attracted tremendous attention and has also been widely used in multistep synthesis. The current reaction methodology starts from the gold activation of unsaturated carbon bond and subsequent nucleophilic attack. The combination of a gold catalyst with another acid catalyst, including Bronsted acid and Lewis acid, is possible to bring two distinctive catalytic systems together and deliver unprecedented new reactions. More essentially, it avoids the purification of unstable intermediates and improves the step and atom economy. Here, the recent progress in the Au/Acid combined catalysis is reviewed, including the scope of reactions, mechanism and synthetic applications.