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Xingxian Zhang

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Organization: Zhejiang University of Technology
Department: College of Pharmaceutical Sciences
Title:
Highly efficient three-component Strecker-type reaction catalyzed by MgI2 etherate under solvent-free conditions
Co-reporter:Pengcheng Li, Yongdong Zhang, Zhili Chen, Xingxian Zhang
Tetrahedron Letters 2017 Volume 58, Issue 19(Issue 19) pp:
Publication Date(Web):10 May 2017
DOI:10.1016/j.tetlet.2017.03.087
•MgI2 etherate could catalyze one-pot three-component Strecker-type condensation.•This magnesium-catalyzed Strecker-type addition is rapid, mild and convenient.•The unique reactivity of this catalytic system was demonstrated.•The condensation of various aldehydes or ketones is performed in excellent yields.A concise, straightforward and efficient method has been developed for the synthesis of α-aminonitriles by an one-pot three-component condensation of aldehydes or ketones, amines and trimethylsilyl cyanide catalyzed by MgI2 etherate under solvent-free conditions. This protocol has some advantages such as mild reaction condition, simple work-up, short reaction time and high product yields.Download high-res image (45KB)Download full-size image
Unique chemoselective Paal-Knorr reaction catalyzed by MgI2 etherate under solvent-free conditions
Co-reporter:Xingxian Zhang, Guodong Weng, Yongdong Zhang, Pengcheng Li
Tetrahedron 2015 Volume 71(Issue 18) pp:2595-2602
Publication Date(Web):6 May 2015
DOI:10.1016/j.tet.2015.03.035
A Facile Solvent-Free Synthesis of Chiral Oxazolidinone Derivatives Catalyzed by MgI2 Etherate: An Approach to Enantiopure Synthesis of Linezolid
Co-reporter:Xingxian Zhang;Chengfeng Zhao ;Yue Gu
Journal of Heterocyclic Chemistry 2012 Volume 49( Issue 5) pp:1143-1146
Publication Date(Web):
DOI:10.1002/jhet.970

A highly efficient and stereoselective cycloaddition of aryl isocyanates with chiral oxiranes catalyzed by MgI2 etherate under solvent-free conditions was developed to prepare the chiral oxazolidinone derivatives. This methodology has been applied into the practical synthesis of antibacterial drug linezolid.

Unique chemoselective Clauson–Kass reaction of substituted aniline catalyzed by MgI2 etherate
Co-reporter:Xingxian Zhang, Junchen Shi
Tetrahedron 2011 67(5) pp: 898-903
Publication Date(Web):
DOI:10.1016/j.tet.2010.12.018
N-[[(1r,2r)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
N-[[(1r,2r)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
CAS:609799-22-6
N-[[(1r,2r)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
4-Vinyl-2,3-dihydrobenzofuran
4-Vinyl-2,3-dihydrobenzofuran
CAS:230642-84-9
4-Vinyl-2,3-dihydrobenzofuran
2,3-bis(2-hydroxyethyl)phenol
2,3-bis(2-hydroxyethyl)phenol
CAS:199391-75-8
2,3-bis(2-hydroxyethyl)phenol
(S)-Methyl 2-amino-2-phenylacetate
(S)-Methyl 2-amino-2-phenylacetate
CAS:37760-98-8
(S)-Methyl 2-amino-2-phenylacetate
Benzeneacetic acid, a-amino-, methyl ester
Benzeneacetic acid, a-amino-, methyl ester
CAS:26682-99-5
Benzeneacetic acid, a-amino-, methyl ester
METHYL L-ALANINATE
METHYL L-ALANINATE
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METHYL L-ALANINATE
(S)-Dimethyl 2-aminopentanedioate
(S)-Dimethyl 2-aminopentanedioate
CAS:6525-53-7
(S)-Dimethyl 2-aminopentanedioate
L-Aspartic acid,1,4-dimethyl ester
L-Aspartic acid,1,4-dimethyl ester
CAS:6384-18-5
L-Aspartic acid,1,4-dimethyl ester
(S)-2-Amino-3-methyl-butyric acid methyl ester
(S)-2-Amino-3-methyl-butyric acid methyl ester
CAS:4070-48-8
(S)-2-Amino-3-methyl-butyric acid methyl ester
L-Cysteine, methylester
L-Cysteine, methylester
CAS:2485-62-3
L-Cysteine, methylester