Daniel R. Nicponski - Cochemist

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Daniel R. Nicponski

Name:

Organization: Purdue University

Department: Department of Chemistry

Title:

Chemicals
References

4-(Dimethylamino)pyridine as a catalyst for the lactonization of 4-hydroxy-2-methylenebutanoate esters

Co-reporter:Daniel R. Nicponski

Tetrahedron Letters 2014 Volume 55(Issue 13) pp:2075-2077

Publication Date(Web):26 March 2014

DOI:10.1016/j.tetlet.2014.02.024

The catalytic action of 4-(dimethylamino)pyridine (DMAP) in lactonizing 4-hydroxy-2-methylenebutanoate esters to 2-methylene-γ-butyrolactones is described. The use of DMAP, which functions as an excellent complement to the more traditional acid-catalyzed lactonization protocol, allows for the synthesis of 2-methylene-γ-butyrolactones containing acid-sensitive groups under essentially neutral conditions.

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