Jiao Bai

Name: 白皎

Organization: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) , China

Department: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Title: Associate Professor(PhD)

Chemicals
References

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Co-reporter:Sheng-Li Niu;Da-Hong Li;Yue-Tong Wang;Kai-Bo Wang;Bin Lin;Yong-Kui Jing;Hui-Ming Hua;Zhan-Lin Li

Organic & Biomolecular Chemistry 2017 vol. 15(Issue 22) pp:4901-4906

Publication Date(Web):2017/06/07

DOI:10.1039/C7OB01007A

Neobraclactones A–C (1–3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI50 values from 0.40 to 0.86 μM.

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Co-reporter:Sheng-Li Niu;Da-Hong Li;Yue-Tong Wang;Kai-Bo Wang;Bin Lin;Yong-Kui Jing;Hui-Ming Hua;Zhan-Lin Li

Organic & Biomolecular Chemistry 2017 vol. 15(Issue 22) pp:4901-4906

Publication Date(Web):2017/06/07

DOI:10.1039/C7OB01007A

Trametramide A, a new pyridone alkaloid from the fungus Trametes trogii TGC-P-3

Co-reporter:Xiqing Bian;Ke Sun;Shengdong Huang;Kaibo Wang;Shuang Tang;Chunmei Xue;Gaosheng Hu;Xin Wu;Huiming Hua;Yuehu Pei

Magnetic Resonance in Chemistry 2016 Volume 54( Issue 9) pp:773-776

Publication Date(Web):

DOI:10.1002/mrc.4451

Penioxalicin, a novel 3-nor-2,3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1

Co-reporter:Xiqing Bian, Jiao Bai, Xiaolan Hu, Xin Wu, Chunmei Xue, Aihong Han, Guangyue Su, Huiming Hua, Yuehu Pei

Tetrahedron Letters 2015 Volume 56(Issue 35) pp:5013-5016

Publication Date(Web):26 August 2015

DOI:10.1016/j.tetlet.2015.07.014

Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.

Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1

Co-reporter:Xiao-Lan Hu, Xi-Qing Bian, Xin Wu, Jian-Yong Li, Hui-Ming Hua, Yue-Hu Pei, Ai-Hong Han, Jiao Bai

Tetrahedron Letters 2014 Volume 55(Issue 29) pp:3864-3867

Publication Date(Web):16 July 2014

DOI:10.1016/j.tetlet.2014.05.104

Penioxalamine A (1), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.

Palmarumycins from the Endophytic Fungus Lasiodiplodia pseudotheobromae XSZ-3

Co-reporter:Xiaojing Lü;Gang Chen;Zhanlin Li;Yuhong Zhang;Zaiying Wang;Weiwei Rong;Yuehu Pei;Huaqi Pan;Huiming Hua

Helvetica Chimica Acta 2014 Volume 97( Issue 9) pp:1289-1294

Publication Date(Web):

DOI:10.1002/hlca.201300436

Abstract

One new and three known spiro-dioxynaphthalene compounds, related to palmarumycins, were isolated from the extracts of fungus Lasiodiplodia pseudotheobromae XSZ-3. Their structures were established by spectroscopic methods (1D- and 2D-NMR, HR-ESI-MS, etc.). The absolute configuration of 1 was determined by comparison of quantum-chemical TDDFT (time-dependent density-functional theory) calculated and experimental ECD (electronic circular dichroism) spectra. The cytotoxic activities of 1–4 against HL-60 cell line were evaluated by trypan blue-staining assay.

Structure determination of two new indole-diterpenoids from Penicillium sp. CM-7 by NMR spectroscopy

Co-reporter:Yu-Hong Zhang;Sheng-Dong Huang;Hua-Qi Pan;Xi-Qing Bian;Zai-Ying Wang;Ai-Hong Han

Magnetic Resonance in Chemistry 2014 Volume 52( Issue 6) pp:306-309

Publication Date(Web):

DOI:10.1002/mrc.4065

Two new indole-diterpenoids 4b-deoxy-1′-O-acetylpaxilline (1) and 4b-deoxypenijanthine A (2) were isolated from the fermentation broth and the mycelia of the soil fungus Penicillium sp. CM-7, along with three known structurally related compounds, 1′-O-acetylpaxilline (3), paspaline (4) and 3-deoxo-4b-deoxypaxilline (5). The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Copyright © 2014 John Wiley & Sons, Ltd.

Butenolide derivatives from the plant endophytic fungus Aspergillus terreus

Co-reporter:Feng Guo, Zhanlin Li, Xiangwei Xu, Kaibo Wang, Meili Shao, Feng Zhao, Haifeng Wang, Huiming Hua, Yuehu Pei, Jiao Bai

Fitoterapia (September 2016) Volume 113() pp:44-50

Publication Date(Web):1 September 2016

DOI:10.1016/j.fitote.2016.06.014

Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), asperteretal B (2), and asperteretal C (3), together with seven known butenolides (4–10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var. assamica. The structures of compounds 1–3 were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra. Compounds 1, 3, 5 and 6–8 showed potent inhibitory effects on NO production in RAW 264.7 lipopolysaccharide-induced macrophages, and compounds 5 and 8 also exhibited moderate cytotoxicity against HL-60 cell line.Download high-res image (120KB)Download full-size image

Lecanicillolide, an α-pyrone substituted spiciferone from the fungus Lecanicillium sp. PR-M-3

Co-reporter:Zaiying Wang, Shengshuang Chen, Xianan Sang, Huaqi Pan, Zhanlin Li, Huiming Hua, Aihong Han, Jiao Bai

Tetrahedron Letters (22 February 2017) Volume 58(Issue 8) pp:

Publication Date(Web):22 February 2017

DOI:10.1016/j.tetlet.2017.01.023

•Lecanicillolide, a novel α-pyrone substituted spiciferone, was isolated from Lecanicillium sp.•Stereochemistry was confirmed by single-crystal X-ray diffraction and ECD calculation.•A plausible biosynthetic pathway for lecanicillolide (1) was also proposed.A novel α-pyrone substituted spiciferone, lecanicillolide (1), was isolated along with structurally related known compounds 2–4 from the fungus Lecanicillium sp. PR-M-3. The structure of lecanicillolide was elucidated by UV, IR, HRESIMS, and NMR spectral data, ECD analysis and confirmed by single-crystal X-ray diffraction. A plausible biosynthetic pathway for lecanicillolide was also proposed.

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Co-reporter:Sheng-Li Niu, Da-Hong Li, Yue-Tong Wang, Kai-Bo Wang, Bin Lin, Yong-Kui Jing, Hui-Ming Hua, Jiao Bai and Zhan-Lin Li

Organic & Biomolecular Chemistry 2017 - vol. 15(Issue 22) pp:NaN4906-4906

Publication Date(Web):2017/05/18

DOI:10.1039/C7OB01007A

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Co-reporter:Sheng-Li Niu, Da-Hong Li, Yue-Tong Wang, Kai-Bo Wang, Bin Lin, Yong-Kui Jing, Hui-Ming Hua, Jiao Bai and Zhan-Lin Li

Organic & Biomolecular Chemistry 2017 - vol. 15(Issue 22) pp:NaN4906-4906

Publication Date(Web):2017/05/18

DOI:10.1039/C7OB01007A