Co-reporter:Meng Huo, Yiyang Zhang, Min Zeng, Lei Liu, Yen Wei, and Jinying Yuan
Macromolecules October 24, 2017 Volume 50(Issue 20) pp:8192-8192
Publication Date(Web):October 5, 2017
DOI:10.1021/acs.macromol.7b01437
Mesogen-containing amphiphilic block copolymers have shown extremely abundant self-assembly behaviors because of the liquid crystalline (LC) alignment within the assemblies. However, development of an understanding of the self-assembly behaviors of these amphiphilic LC polymers is still constrained by the low assembly concentration and complex kinetic effects. Polymerization-induced self-assembly (PISA) is a powerful technique to prepare polymer assemblies at high solids content with good repeatability. Taking advantage of PISA, we systematically study the self-assembly behaviors of a series of mesogen-containing triblock copolymers poly(2-dimethylaminoethyl methacrylate)-b-poly(benzyl methacrylate)-b-poly(2-perfluorooctylethyl methacrylate) (PDMA-b-PBzMA-b-PFMA), which are prepared by seeded reversible addition–fragmentation chain transfer dispersion polymerization of FMA with PDMA-b-PBzMA micelles or vesicles as the seeds. When PDMA-b-PBzMA micelles are used, the morphology of the PDMA-b-PBzMA-b-PFMA assemblies evolves from spheroid to phase-segregated sphere, followed by phase-segregated spheroid, and eventually to cylinder, while the assemblies undergo a vesicle-to-micelle transition with a framboidal intermediate when PDMA-b-PBzMA vesicles are used as the seeds. These spherical micelles further fuse to cylinders or large spheres depending on the DPs of PBzMA and PFMA blocks. The LC ordering of the PFMA blocks is examined by differential scanning calorimetry and X-ray diffraction; the microphase segregation between PFMA and PBzMA blocks is studied with TEM and atomic force microscopy. These experiments evince that the formation of the ellipsoidal and cylindrical micelles is driven by the LC alignment of PFMA blocks, while the microphase segregation between PFMA and PBzMA blocks complicates the ultimate morphology through modulating the size of PFMA nanodomains. The interplay of the hydrophobic interaction among PBzMA blocks, lipophobic interaction, and LC ordering of PFMA blocks thus generates the above self-assembly behaviors.
Co-reporter:Meng Huo, Min Zeng, Dan Li, Lei Liu, Yen Wei, and Jinying Yuan
Macromolecules October 24, 2017 Volume 50(Issue 20) pp:8212-8212
Publication Date(Web):October 9, 2017
DOI:10.1021/acs.macromol.7b01629
Polymer self-assembly has been one of the most important strategies for preparation of multicompartment micelles (MCMs). However, the traditional self-assembly techniques are constrained by limited common solvent, complex kinetic factors, low solids content, etc. Polymerization-induced self-assembly (PISA) is a novel technique for preparation of polymer assemblies at high solids content and has been exploited to produce MCMs. Nevertheless, the morphology evolution of the MCMs obtained through PISA has not yet been well understood. Herein, we study the compartmentalization behaviors of a series of MCMs constituted by poly(N,N-dimethylaminoethyl methacrylate)-b-poly(benzyl methacrylate)-b-poly(2-perfluorohexylethyl methacrylate) (PDMA-b-PBzMA-b-PFHEMA) triblock terpolymers, which were synthesized by seeded reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization of FHEMA using PDMA-b-PBzMA micelles, wormlike micelles, or vesicles as the seeds. Because of the strong incompatibility between PBzMA and PFHEMA, MCMs with abundant compartmentalized nanostructures were produced. Phosphotungstic acid- and RuO4-stained TEM images of these MCMs indicate that their morphologies are controlled by both the DPs of PBzMA and PFHEMA. Our results suggest that PISA could serve as a reliable platform for revealing the compartmentalization behaviors of polymeric assemblies.
Co-reporter:Meng Huo, Ziyang Xu, Min Zeng, Pengyu Chen, Lei Liu, Li-Tang Yan, Yen Wei, and Jinying Yuan
Macromolecules December 26, 2017 Volume 50(Issue 24) pp:9750-9750
Publication Date(Web):December 5, 2017
DOI:10.1021/acs.macromol.7b02039
The significance of polymer topology to the size and morphology of polymeric assemblies was less studied. Herein we report the preparation of polymersomes with tunable sizes via topological engineering of the solvophobic block of the amphiphilic copolymer in polymerization-induced self-assembly (PISA). The topology of the solvophobic block could be facilely regulated by reversible addition–fragmentation chain transfer (RAFT) dispersion copolymerization of two kinds of monomers with distinctive molecular geometries at variable feed ratios. As a proof-of-concept study, RAFT dispersion copolymerization of benzyl methacrylate (BzMA) and stearyl methacrylate (SMA) produced polymersomes with size ranging from 200 to 1500 nm depending on the ratio of BzMA/SMA. Besides vesicles, assemblies with complex internal structures were obtained by varying the ratio of BzMA/SMA, suggesting the robustness of this strategy. The mechanism was revealed by a series of coarse-grained molecular simulations, which elucidated the dependence of the packing parameter on the composition of the solvophobic block. The generality and modularity for regulating vesicular size by topological engineering of solvophobic block were further established by RAFT dispersion copolymerization of BzMA and 2-(perfluorooctyl)ethyl methacrylate, which also generated polymersomes with tunable sizes. The topological engineering of copolymer by RAFT dispersion copolymerization thus serves as a versatile and modular approach to controlling the size and morphology of polymer assemblies.
Co-reporter:Liao Peng, Senyang Liu, Anchao Feng, and Jinying Yuan
Molecular Pharmaceutics August 7, 2017 Volume 14(Issue 8) pp:2475-2475
Publication Date(Web):May 2, 2017
DOI:10.1021/acs.molpharmaceut.7b00160
Stimuli responsive polymers have been extensively studied as nanocarriers for drug delivery systems (DDSs), especially those based on supramolecular interactions. Cyclodextrin (CD) is one kind of widely applied host molecule, and the host–guest interactions between CD and different counterparts can respond to different stimuli and thus can be applied as responsive linkers for polymeric DDSs. In this review, the polymeric nanocarriers based on the host–guest interactions between CD and ferrocene, azobenzene, and benzimidazole as DDSs are summarized, with redox, light, and pH sensitivity, respectively. The mechanisms for the stimuli responsive ability of the linkers, the application of them for construction of DDSs with different polymer structures, and the controlled release behaviors have been focused. In addition, the outlook and challenge of these systems are discussed.Keywords: drug delivery systems; host−guest chemistry; polymer self-assembly; stimuli responsive polymers; supramolecular structures;
Co-reporter:Xi Chen;Dr. Lei Liu;Meng Huo;Min Zeng;Liao Peng;Dr. Anchao Feng; Xiaosong Wang; Jinying Yuan
Angewandte Chemie 2017 Volume 129(Issue 52) pp:16768-16772
Publication Date(Web):2017/12/22
DOI:10.1002/ange.201709129
AbstractA one-step synthesis of nanotubes by RAFT dispersion polymerization of cyclodextrin/styrene (CD/St) complexes directly in water is presented. The resulted amphiphilic PEG-b-PS diblock copolymers self-assemble in situ into nanoparticles with various morphologies. Spheres, worms, lamellae, and nanotubes were controllably obtained. Because of the complexation, the swelling degree of polystyrene (PS) blocks by free St is limited, resulting in limited mobility of PS chains. Consequently, kinetically trapped lamellae and nanotubes were obtained instead of spherical vesicles. During the formation of nanotubes, small vesicles first formed at the ends of the tape-like lamellae, then grew and fused into nanotubes with a limited chain rearrangement. The introduction of a host–guest interaction based on CDs enables the aqueous dispersion polymerization of water-immiscible monomers, and produces kinetically trapped nanostructures, which could be a powerful technique for nanomaterials synthesis.
Co-reporter:Hailong Che;Jinying Yuan
Macromolecular Research 2017 Volume 25( Issue 6) pp:635-639
Publication Date(Web):18 July 2017
DOI:10.1007/s13233-017-5133-6
CO2-responsive bowl-shaped polymersomes caused by osmotic pressure have been successfully designed and constructed. Upon CO2-stimulus, these polymersomes can transform from bowl-shape into wrinkled structure because of the restricted hydration effect. These promising polymersomes with special structure upon exposure to biological gas are expected to be useful in nanomedicine.
Co-reporter:Lilin Zhou;Xiaoyong Zhang;Lei Liu;Yen Wei;Jinying Yuan
Chinese Journal of Chemistry 2017 Volume 35(Issue 6) pp:977-983
Publication Date(Web):2017/06/01
DOI:10.1002/cjoc.201600803
Multifunctional fluorescent magnetic nanoparticles (Fe3O4@SiO2-PLLA-RhB/FA) with cell recognition ability were synthesized through conjugation of magnetic nanoparticles with folic acid (FA) and Rhodamine B. To verify their potential biomedical applications, biocompatibility as well as cell imaging applications of the multifunctional nanoparticles were further investigated. Results showed that these fluorescent magnetic nanoparticles are well biocompatible with NIH-3T3 cells and HeLa cells. More importantly, these nanoparticles could be selectively taken up by HeLa cells (FA receptor positive) as evidenced by laser scanning confocal microscopy, suggesting their potential for biological imaging applications. Given their excellent biocompatibility and multifunctional characteristics, we expect that the fluorescent magnetic nanoparticles could be promising for various biomedical applications.
Co-reporter:Xi Chen;Dr. Lei Liu;Meng Huo;Min Zeng;Liao Peng;Dr. Anchao Feng; Xiaosong Wang; Jinying Yuan
Angewandte Chemie International Edition 2017 Volume 56(Issue 52) pp:16541-16545
Publication Date(Web):2017/12/22
DOI:10.1002/anie.201709129
AbstractA one-step synthesis of nanotubes by RAFT dispersion polymerization of cyclodextrin/styrene (CD/St) complexes directly in water is presented. The resulted amphiphilic PEG-b-PS diblock copolymers self-assemble in situ into nanoparticles with various morphologies. Spheres, worms, lamellae, and nanotubes were controllably obtained. Because of the complexation, the swelling degree of polystyrene (PS) blocks by free St is limited, resulting in limited mobility of PS chains. Consequently, kinetically trapped lamellae and nanotubes were obtained instead of spherical vesicles. During the formation of nanotubes, small vesicles first formed at the ends of the tape-like lamellae, then grew and fused into nanotubes with a limited chain rearrangement. The introduction of a host–guest interaction based on CDs enables the aqueous dispersion polymerization of water-immiscible monomers, and produces kinetically trapped nanostructures, which could be a powerful technique for nanomaterials synthesis.
Co-reporter:Meng Huo;Haotian Du;Min Zeng;Long Pan;Tommy Fang;Xuming Xie;Yen Wei;Jinying Yuan
Polymer Chemistry (2010-Present) 2017 vol. 8(Issue 18) pp:2833-2840
Publication Date(Web):2017/05/09
DOI:10.1039/C7PY00214A
The integration of stimuli-responsive polymers with polymeric assemblies enables exquisite control over their nanostructures. Herein, we report the CO2-regulated self-assembly behaviors of a series of amphiphilic miktoarm star terpolymers star-[poly(ethylene glycol)-polystyrene-poly[2-(N,N-diethylamino)ethyl methacrylate]] (μ-PEG-PS-PDEA). These μ-PEG-PS-PDEA assemblies show enhanced CO2-responsibility with the increase in the molecular weight (Mn) of the PDEA segment. For μ-PEG-PS-PDEAx (x represents the Mn of the PDEA block, x = 9.3k, 12.2k, 25k), we observed an unusual sphere/vesicle-to-lamella transition upon CO2 stimulation. As the Mn of PDEA increases from 9.3k to 25k, the morphology of these lamellae evolves from nanophase segregated “E. coli-shaped” nanosheets to nanoribbons, then to nanodiscs. We studied the pH, zeta potential and the microscopy images of the assemblies before and after CO2 stimulation, and accordingly speculated the possible mechanisms for the morphology transformation and the nanophase segregation. Our results indicate that the combination of CO2 stimulation with miktoarm star polymers could potentially extend the horizon of macromolecular self-assembly.
Co-reporter:Tommy Fang;Meng Huo;Zhengyi Wan;Hongge Chen;Liao Peng;Lei Liu;Jinying Yuan
RSC Advances (2011-Present) 2017 vol. 7(Issue 5) pp:2513-2519
Publication Date(Web):2017/01/04
DOI:10.1039/C6RA25196J
A series of polymeric dispersants in three different structural types, namely AB diblock, ABA triblock and comb, were synthesised via reversible addition–fragmentation chain transfer (RAFT) polymerisation. They were systematically designed and optimised with varying molecular weights, compositions, anchoring and stabilising chain lengths, then investigated and compared over the dispersion performance of SiO2 particles in organic media. The comparisons indicated that the optimised AB diblock poly(2-(dimethylamino)ethyl methacrylate)30-b-poly(ethyl methacrylate)40 (PD30-b-PE40) and ABA triblock (PD30-b-PE60-b-PD30) dispersants enabled homogeneous SiO2 particle dispersion, which were more effective in reducing particle size and system viscosity than the comb dispersant poly((2-(dimethylamino)ethyl methacrylate)30-co-(poly(propylene glycol) acrylate)15) (P(D30-co-PPGA15)). In particular, it was found that AB diblock copolymer dispersants are generally at least as effective as or better than their ABA triblock equivalents in particle dispersion and stabilisation. Thus, the dispersion effectiveness of the three structural types can be ordered as: AB ≥ ABA > comb. Furthermore, structure–performance relationships were developed between dispersants' molecular structures and dispersion performances, in order to provide constructive guidance for the structural design and selection of polymeric dispersants for effective particle dispersion and stabilisation in organic media for various applications.
Co-reporter:Meng Huo, Qiquan Ye, Hailong Che, Xiaosong Wang, Yen Wei, and Jinying Yuan
Macromolecules 2017 Volume 50(Issue 3) pp:
Publication Date(Web):January 25, 2017
DOI:10.1021/acs.macromol.6b02499
The correlation of aggregation-induced emission (AIE) to the nanostructure of polymer assemblies was investigated. A series of AIE-active PDMA-b-P(BzMA-TPE) [PDMA: poly(N,N-dimethylaminoethyl methacrylate); P(BzMA-TPE): poly[benzyl methacrylate-co-1-ethenyl-4-(1,2,2-triphenylethenyl)benzene]] assemblies with controlled nanostructures were prepared via polymerization-induced self-assembly of BzMA and TPE, an AIEgen, in the presence of PDMA macro-chain-transfer agents. We found that the fluorescence intensity and fluorescent quantum yield increase in the order of vesicles > wormlike micelles > spherical micelles. For spherical micelles and vesicles, the AIE effect strengthens with increase in micellar size and wall thickness, respectively. As the AIE effect indicates the packing compactness of the AIEgens, the discovered structure-correlated emission can be attributed to the stress variation of polymer chains in the aggregates. AIE is therefore potentially useful as a probe for the investigation and understanding of nanostructure and evolution process of polymer self-assemblies.
Co-reporter:Jun Guo, Niejun Wang, Liao Peng, Jingjun Wu, Qiquan Ye, Anchao Feng, Zhipeng Wang, Chong Zhang, Xin-Hui Xing and Jinying Yuan
Journal of Materials Chemistry A 2016 vol. 4(Issue 22) pp:4009-4016
Publication Date(Web):03 May 2016
DOI:10.1039/C6TB00259E
Electrochemical stimulus is a clean and simple choice of stimulating source in the field of stimuli-responsive materials. Herein, we report an electrochemically-responsive hybrid assembly of magnetic nanoparticles (Fe3O4@SiO2-PGMA-CD) and polyethylene glycol-Fc (PEG-Fc) based on the host–guest interaction between β-cyclodextrin and ferrocene groups. Through electrochemical control, the hydrophilic polymer chains can be reversibly linked to or dropped off from the surface of the magnetic nanoparticles. Thus, the hydrophobic property of the surface together with the protein adsorption ability of the magnetic nanoparticles can be conveniently adjusted by voltages applied. A reversible protein adsorption/release transition from this novel hybrid material has been realized, demonstrated by the bovine serum albumin adsorption experiment. Therefore, an elegant material is introduced to achieve electrochemically-controlled reversible magnetic separation of proteins.
Co-reporter:Anchao Feng, Liao Peng, Bowen Liu, Senyang Liu, Shanfeng Wang, and Jinying Yuan
ACS Applied Materials & Interfaces 2016 Volume 8(Issue 17) pp:11024
Publication Date(Web):March 30, 2016
DOI:10.1021/acsami.5b12864
We present a new, efficient approach to achieve superior dispersibility of single-walled carbon nanotubes (SWNTs) in water by integrating reversible host–guest interaction and π–π stacking. In this approach, β-cyclodextrin (β-CD) was first modified with a pyrene group to be adsorbed onto the wall of pristine SWNTs via π–π stacking, followed by further functionalization with ferrocene (Fc)-terminated water-soluble poly(ethylene glycol) (PEG) through supramolecular host–guest interaction between β-CD and Fc. Upon alternate electrochemical oxidative/reductive stimuli, the reversible host–guest pair enabled the PEG-Fc@Py-CD@SWNTs to exhibit switchable conversion between dispersion and aggregation states. Electric field controllable PEG-Fc@Py-CD@SWNTs with good reversibility and intact nanotube structure may find potential applications in selective screening of SWNTs, biosensors, and targeted drug delivery.Keywords: dispersion of SWNTs; electrochemical redox switch; host−guest interaction; single-walled carbon nanotubes (SWNTs); stimuli-responsive polymer
Co-reporter:Liao Peng, Anchao Feng, Senyang Liu, Meng Huo, Tommy Fang, Ke Wang, Yen Wei, Xiaosong Wang, and Jinying Yuan
ACS Applied Materials & Interfaces 2016 Volume 8(Issue 43) pp:29203
Publication Date(Web):October 14, 2016
DOI:10.1021/acsami.6b09920
Potential-stimulated Pickering emulsions, using electrochemical responsive microgels as particle stabilizers, are prepared and used for biocatalysis. The microgels are constructed from cyclodextrin functionalized 8-arm poly(ethylene glycol) (8A PEG-CD) and ferrocene modified counterparts (8A PEG-Fc) via CD/Fc host–guest chemistry. Taking advantage of the redox reaction of Fc, the formation and deformation of the microgels and corresponding Pickering emulsions can be reversibly stimulated by external potential, and have been used for the hydrolysis of triacetin and kinetic resolution reaction of (R,S)-1-phenylethanol catalyzed by lipases. Potential stimulated destabilization of the emulsion realizes an effective separation of the products and enzyme recycling.Keywords: biocatalysis; electrochemical responsiveness; host−guest chemistry; Pickering emulsion; polymer self-assembly
Co-reporter:Liao Peng, Zilin Wang, Anchao Feng, Meng Huo, Tommy Fang, Ke Wang, Yen Wei, Jinying Yuan
Polymer 2016 Volume 88() pp:112-122
Publication Date(Web):6 April 2016
DOI:10.1016/j.polymer.2016.02.023
•The supramolecular micelles are based on cyclodextrin-ferrocene linker.•Star polymers make the micelles have higher drug loading efficiency.•The micelles can reversibly respond to electrochemical stimuli.•The micelles can load doxorubicin and release it under regulation of potential.•Good biocompatibility endows the micelles wide applications in real-life systems.Research interest in electrochemical redox stimulus has grown considerably due to its easy trigger mode, in which the linkers have played important roles, such as the β-cyclodextrin-ferrocene (β-CD-Fc) linker. Star amphiphilic copolymers with well-defined and flexible structures are considered to be excellent choices for drug delivery systems (DDSs). Driven by the idea that using star polymers to improve the biocompatibility and efficiency of the β-CD-Fc-based DDS, we designed and synthesized star polymer 4 arm-poly(ε-caprolactone)-β-CD (4A PCL-CD) and linear polymer polyethylene glycol-Fc (PEG-Fc). They can form supramolecular block copolymer 4A PCL-CD/Fc-PEG and self-assemble to micelles, which are electrochemical responsive and can be applied as drug carriers for potential controlled release, with higher efficiency and better biocompatibility compared with their linear analogues.Micelles were constructed based on 4 arm-poly(ε-caprolactone)-β-CD and polyethylene glycol-Fc, which are electrochemical responsive and can be applied as drug carriers for potential controlled release. Compared with their linear analogues, these micelles have significantly higher drug loading efficiency, better biocompatibility and more stable stable release behaviour, which is of great importance in real applications.
Co-reporter:Hailong Che, Meng Huo, Liao Peng, Qiquan Ye, Jun Guo, Ke Wang, Yen Wei and Jinying Yuan
Polymer Chemistry 2015 vol. 6(Issue 12) pp:2319-2326
Publication Date(Web):22 Jan 2015
DOI:10.1039/C4PY01800A
CO2-responsive well-defined core–shell–corona structure magnetic Fe3O4@SiO2-poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) nanocarriers have been developed as efficient drug delivery systems. The hybrid magnetic nanoparticles (MNPs) demonstrated a sandwich structure and highly super-paramagnetic biocompatibility properties as well as gas-responsive behavior. We found that the hydrodynamic radius (Rh) of the magnetic hybrid nanoparticles could be adjusted by alternate CO2/N2 treatment driving a switchable volume transition from contraction to expansion because of the CO2 responsiveness of PDMAEMA. The CO2-triggered protonation of the polymer shell gives rise to an obvious zeta potential change of the nanoparticles. Importantly, the CO2 induced reversible “on–off” transformation makes it possible to perform a dosage release of doxorubicin (DOX) in vitro in a time-controllable manner which is of great significance in controlled drug release. In the presence of CO2, the drug release rate is significantly accelerated, while low drug release could be achieved by removal of CO2 using N2. Moreover, the in vitro cytotoxicity test indicated that the CO2-responsive magnetic nanocarriers have good biocompatibility and could be safely used in living systems.
Co-reporter:Liao Peng, Huijuan Zhang, Anchao Feng, Meng Huo, Zilin Wang, Jin Hu, Weiping Gao and Jinying Yuan
Polymer Chemistry 2015 vol. 6(Issue 19) pp:3652-3659
Publication Date(Web):23 Mar 2015
DOI:10.1039/C5PY00296F
A supramolecular hydrogel was prepared through the host–guest interaction between β-cyclodextrin (β-CD) and ferrocene (Fc) with two polymers as pendant groups. Reversible gel–sol transition was observed with the alternative stimuli of a positive potential (or an oxidant) and a negative potential (or a reductant). The hydrogel not only had good self-healing ability due to the dynamic host–guest interaction, but also was prepared under mild conditions and could respond to moderate electrochemical stimuli. Good biocompatibility endowed the hydrogel with potential practical and real-life applications, especially in tissue engineering and drug release field.
Co-reporter:Bo-wen Liu, Hang Zhou, Si-tong Zhou, Jin-ying Yuan
European Polymer Journal 2015 Volume 65() pp:63-81
Publication Date(Web):April 2015
DOI:10.1016/j.eurpolymj.2015.01.017
•Macromolecules based on the host–guest interaction were discussed.•Progress are reviewed, including adamantane, azobenzene and ferrocene as guest molecules.•Topological structures including linear, branched, comb and hyper-branched polymers were discussed.•The responsiveness to various stimuli and potential applications were presented.Highly stable inclusion complexes between cyclodextrin (CD) and guest molecules form due to their host–guest interaction. Polymer systems based on the complexes have been extensively reported in recent years. In this review, we highlight some recent advances from polymer systems with adamantane (Ada), azobenzene (Azo), ferrocene (Fc) and so on as guest molecules in terms of their synthesis, properties and functions. Various polymer topologies ranging from linear, branched, comb-like and hyper-branched are discussed in detail. In addition, the related systems with environmental stimuli-responsiveness and their potential applications are also presented.
Co-reporter:Jun Guo, Liao Peng, Jinying Yuan
European Polymer Journal 2015 Volume 69() pp:449-459
Publication Date(Web):August 2015
DOI:10.1016/j.eurpolymj.2015.03.033
•Molecular brushes are polymers attaching densely side chains onto the backbone.•Advances in the molecular brushes respond to dual and multi-stimuli are highlighted.•The multi-stimuli involve temperature, pH, light, ion strength, and so on.•We discuss the designing principles, response mode, and applications.Molecular brushes are a class of copolymerized polymers by densely attaching the side chains onto the polymer backbone. Due to the unique architecture, the molecular brushes are very informative model systems for the studies of polymer properties, and have applications in many fields, including biomimetics. This Feature Article highlights the recent advances in the molecular brushes which could respond to dual and multi stimuli, such as temperature, pH, light irradiation, ion strength, redox and electric field. We discussed examples that illustrate the designing principles, response manners, and applications of dual and multi-responsive molecular brushes. The challenges and future research trends are also presented.
Co-reporter:Meng Huo, Niejun Wang, Tommy Fang, Mengzhen Sun, Yen Wei, Jinying Yuan
Polymer 2015 Volume 66() pp:A11-A21
Publication Date(Web):1 June 2015
DOI:10.1016/j.polymer.2015.04.011
•Controlled/“living” polymerization has actuated the design of single chain polymer nanoparticles (SCPNs).•One important application of SCPNs is protein mimicry.•The development of SCPNs in terms of different crosslinking strategies and their potential applications were reviewed.•The characterization techniques for SCPNs study were summarized.With recent development in controlled/“living” polymerization and sequence-specific polymeric architecture design, polymeric materials with accurately designed primary structure can be to some extent designed and prepared. Such development has actuated the design of single chain polymer nanoparticles (SCPNs) with tunable high-order structures from well-defined polymeric precursors. Until now, various synthetic strategies for SCPNs have been proposed and some possible applications, especially protein mimicry, have demonstrated the SCPNs' attracting prospect. After briefly introducing the origin of SCPNs, this feature article reviewed the recent development of SCPNs in terms of different crosslinking strategies as well as their potential applications. Meanwhile, we highlighted some important characterization techniques for SCPNs study.Figure optionsDownload full-size imageDownload as PowerPoint slide
Co-reporter:Yan Xin;Hong Wang;Bo-wen Liu 袁金颖
Chinese Journal of Polymer Science 2015 Volume 33( Issue 1) pp:36-48
Publication Date(Web):2015 January
DOI:10.1007/s10118-015-1572-8
In this paper, three different kinds of β-CD derivatives were synthesized as atom transfer radical polymerization (ATRP) initiator or reversible addition-fragmentation chain transfer polymerization (RAFT) chain transfers. The degree of substitution for each derivative was carefully characterized through 1H-NMR, 13C-NMR spectroscopy and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). The factors influencing the degree of substitution were discussed. Moreover, the comparison between ATRP and RAFT was shown in the polymerization of N-isopropyl acrylamide (NIPAM).
Co-reporter:Hailong Che;Meng Huo;Liao Peng;Tommy Fang;Na Liu; Lin Feng; Yen Wei; Jinying Yuan
Angewandte Chemie International Edition 2015 Volume 54( Issue 31) pp:8934-8938
Publication Date(Web):
DOI:10.1002/anie.201501034
Abstract
Responsive polymer interfacial materials are ideal candidates for controlling surface wetting behavior. Here we developed smart nanostructured electrospun polymer membranes which are capable of switching oil/water wettability using CO2 as the trigger. In particular, the combination of CO2-responsiveness and porous nanostructure enables the as-prepared membranes to be used as a novel oil/water on–off switch. We anticipate that the promising versatility and simplicity of this system would not only open up a new way of surface wettability change regulation by gas, but also have obvious advantages in terms of highly controlled oil/water separation and CO2 applications.
Co-reporter:Hailong Che;Meng Huo;Liao Peng;Tommy Fang;Na Liu; Lin Feng; Yen Wei; Jinying Yuan
Angewandte Chemie 2015 Volume 127( Issue 31) pp:9062-9066
Publication Date(Web):
DOI:10.1002/ange.201501034
Abstract
Responsive polymer interfacial materials are ideal candidates for controlling surface wetting behavior. Here we developed smart nanostructured electrospun polymer membranes which are capable of switching oil/water wettability using CO2 as the trigger. In particular, the combination of CO2-responsiveness and porous nanostructure enables the as-prepared membranes to be used as a novel oil/water on–off switch. We anticipate that the promising versatility and simplicity of this system would not only open up a new way of surface wettability change regulation by gas, but also have obvious advantages in terms of highly controlled oil/water separation and CO2 applications.
Co-reporter:Jun Guo, Niejun Wang, Jingjun Wu, Qiquan Ye, Chong Zhang, Xin-Hui Xing and Jinying Yuan
Journal of Materials Chemistry A 2014 vol. 2(Issue 4) pp:437-442
Publication Date(Web):01 Nov 2013
DOI:10.1039/C3TB21264E
CO2-responsive polymer poly(N,N-diethylaminoethylmethacrylate)-modified magnetic nanoparticles (Fe3O4@dye/SiO2–PDEAEMA) were synthesized by atom transfer radical polymerization from the surfaces of silica coated, dye-labelled iron oxide nanoparticles (Fe3O4@dye/SiO2). TEM, FT-IR, and TGA confirmed and quantified the grafted polymer brushes. The prepared magnetic nanoparticles (MNPs) were fluorescence labelled, as shown by the fluorescence spectra and fluorescence microscopy images. This indicated that the nanoparticles could be utilized as imaging probes to monitor the movement of biological cells or other systems. The PDEAEMA polymer brushes on the surface of MNPs endowed them with a protein adsorption ability. The polymer was also CO2-responsive, so it was a CO2-triggered reversible protein adsorption/release material, which was demonstrated by the bovine serum albumin (BSA) adsorption experiments. The results indicated that the reversible adsorption/release of protein by bubbling CO2 and N2 alternately was easy to achieve.
Co-reporter:Liao Peng, Anchao Feng, Meng Huo and Jinying Yuan
Chemical Communications 2014 vol. 50(Issue 86) pp:13005-13014
Publication Date(Web):14 Jul 2014
DOI:10.1039/C4CC05192K
Electrochemical stimuli have attracted much attention in recent years as they are simple, clean and can be widely applied in biological systems and material science. As one type of common guest molecules, ferrocene and its derivatives have been well studied with different host molecules, mainly including cyclodextrins, cucurbiturils, pillararenes and calixarenes. This article generally summarizes the recent work on the host–guest interactions between ferrocene derivatives and their host molecules, as well as various supramolecular systems based on these interactions. In addition, the development and outlook of electrochemical responsive systems are also discussed.
Co-reporter:Anchao Feng, Chengbo Zhan, Qiang Yan, Bowen Liu and Jinying Yuan
Chemical Communications 2014 vol. 50(Issue 64) pp:8958-8961
Publication Date(Web):17 Jun 2014
DOI:10.1039/C4CC03156C
CO2-responsiveness is imported into amphiphilic block copolymers, poly[(N,N-diethylaminoethyl methacrylate)-b-(N-isopropylacrylamide)] (PDEAEMA-b-PNIPAM), and a system dual-responsive to CO2 and temperature is constructed. The copolymer self-assembles in aqueous solution, and undergoes phase transition when CO2 and temperature stimuli occur, since the stimuli give rise to the conversion of the hydrophilicity of both blocks. Combining CO2 and temperature as triggers, schizophrenic micelle to vesicle morphological transition of the polymer assemblies is controlled.
Co-reporter:Anchao Feng, Qiang Yan, Huijuan Zhang, Liao Peng and Jinying Yuan
Chemical Communications 2014 vol. 50(Issue 36) pp:4740-4742
Publication Date(Web):11 Feb 2014
DOI:10.1039/C4CC00463A
The end-decorated homopolymer poly(ε-caprolactone)-ferrocene threaded onto a β-cyclodextrin-functionalized main-chain polymer can form a class of amphiphilic noncovalent graft copolymers based on the host–guest interactions of the terminal groups on the side chains. These new supramolecular polymer brushes can further self-assemble into micellar aggregates that exhibit reversible assembly and disassembly behavior under an electrochemical redox trigger, which opens up a new route to building dynamic block copolymer topologies.
Co-reporter:Liao Peng, Anchao Feng, Huijuan Zhang, Hong Wang, Chunmei Jian, Bowen Liu, Weiping Gao and Jinying Yuan
Polymer Chemistry 2014 vol. 5(Issue 5) pp:1751-1759
Publication Date(Web):18 Oct 2013
DOI:10.1039/C3PY01204B
Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on β-cyclodextrin (β-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two biocompatible homopolymers, namely, the poly(ethylene glycol) homopolymer modified with β-CD (PEG–β-CD) and the poly(L-lactide) homopolymer modified with Fc (PLLA–Fc). Through host–guest interactions between β-CD and Fc, the two homopolymers connect together, forming a non-covalent supramolecular block copolymer PLLA–Fc/PEG–β-CD. PLLA–Fc/PEG–β-CD can further self-assemble to form stable micelles in aqueous solution. Through electrochemical control, a reversible assembly–disassembly transition of this micellar system was realized. Voltage-controlled drug release based on this system was also conducted successfully.
Co-reporter:Anchao Feng ;Jinying Yuan
Macromolecular Rapid Communications 2014 Volume 35( Issue 8) pp:767-779
Publication Date(Web):
DOI:10.1002/marc.201300866
Co-reporter:Chunmei Jian, Cheng Gong, Shiqi Wang, Shanfeng Wang, Xuming Xie, Yen Wei, Jinying Yuan
European Polymer Journal 2014 Volume 55() pp:235-244
Publication Date(Web):June 2014
DOI:10.1016/j.eurpolymj.2014.04.003
•Well-defined comb copolymer EC-g-PCL was synthesized through ROP.•EC-g-PCL was further modified with rhodamine B and folate via dehydration.•Thermal properties of the biocompatible and biodegradable EC-g-PCL were explored.•Multifunctional EC-g-PCL shows fluorescence and a specific bonding to cancer cell.Well-defined comb copolymer ethyl cellulose-g-poly(ε-caprolactone) (EC-g-PCL) with good biocompatibility and biodegradability was synthesized through ring-opening polymerization (ROP) using ethyl cellulose (EC) as backbone. EC-g-PCL was further modified with rhodamine B (RhB) and folate (FA) via coupling reactions to obtain EC-g-PCL-RhB/FA with fluorescence and targeting functionality. Nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC) were applied to confirm the molecular structures of the comb copolymers. Thermogravimetric analyzer (TGA), differential scanning calorimeter (DSC) and polarized optical microscope (POM) were utilized to investigate the thermal and crystalline properties of EC-g-PCL-RhB/FA, which were distinct from the corresponding properties of EC-g-PCL without RhB and FA. The characteristic signals in UV–vis and fluorescence spectra demonstrated the capacity of EC-g-PCL-RhB/FA serving as fluorescent probe. Laser scanning confocal microscopy (LSCM) confirmed the bonding of EC-g-PCL20-RhB/FA to HeLa cells with FA as targeting ligand. Such multifunctional comb copolymer EC-g-PCL-RhB/FA has potential applications in the field of targeted drug release.
Co-reporter:Niejun Wang, Lilin Zhou, Jun Guo, Qiquan Ye, Jin-Ming Lin, Jinying Yuan
Applied Surface Science 2014 Volume 305() pp:267-273
Publication Date(Web):30 June 2014
DOI:10.1016/j.apsusc.2014.03.054
Highlights
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Superparamagnetic hybrid nanoparticles were synthesized through a graft through method.
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Ordinary radical polymerization were performed instead of atom transfer radical polymerization.
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Adsorption of model environmental pollutants using these nanoparticles were studied detailedly.
Co-reporter:Bo-wen Liu, Hang Zhou, Si-tong Zhou, Hui-juan Zhang, An-Chao Feng, Chun-mei Jian, Jin Hu, Wei-ping Gao, and Jin-ying Yuan
Macromolecules 2014 Volume 47(Issue 9) pp:2938-2946
Publication Date(Web):April 21, 2014
DOI:10.1021/ma5001404
Poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) with a β-cyclodextrin (β-CD) at the chain end was synthesized via atom transfer radical polymerization (ATRP); poly(ε-caprolactone) (PCL) with a −C═C– segment and an adamantane (Ada) group at two ends, respectively, was prepared through ring-opening polymerization (ROP), and poly(N-isopropylacrylamide) (PNIPAM) with a −S–C(S)–S– segment, which can be converted into a thiol group, was yielded by reversible addition–fragmentation chain transfer polymerization (RAFT). A supramolecular triblock stimuli-responsive copolymer PNIPAM-b-PCL-b-PDMAEMA having good biocompatibility with PNIPAM and PDMAEMA hydrophilic segments and PCL hydrophobic segment was constructed by thiol–ene Michael addition and host–guest interaction. The triblock copolymer could self-assemble into vesicles and respond to carbon dioxide (CO2) gas and temperature reversibly. Under the stimulation of CO2, the vesicular assemblies swelled obviously; while raising the temperature from 25 to 40 °C, the assemblies displayed a conversion between vesicles and spherical micelles.
Co-reporter:Chun-mei Jian;Bo-wen Liu;Xi Chen;Si-tong Zhou
Chinese Journal of Polymer Science 2014 Volume 32( Issue 6) pp:690-702
Publication Date(Web):2014 June
DOI:10.1007/s10118-014-1450-9
In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose (EC) was constructed, combining the host-guest interaction of β-cyclodextrin (β-CD) group and trans-isomer of azobenzene (tAzo) group. To link β-CD to the hydrophobic section, renewable EC was used as macroinitiator to initiate the polymerization of ɛ-caprolactone (ɛ-CL) to form biocompatible and biodegradable comb copolymer EC-g-PCL, and β-CD was attached to the end of PCL side chain via click reaction. Meanwhile, hydrophilic PEG-tAzo was obtained by N,N′-dicyclohexylcarbodiimide (DCC) coupling. Then, the structures of the products were characterized by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). Subsequently, with the formation of inclusion complexes by β-CD and tAzo groups, the obtained EC-g-PCL-β-CD/PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL-β-CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scattering (DLS) and transmission electron microscopy (TEM) were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles.
Co-reporter:Qiang Yan, Anchao Feng, Huijuan Zhang, Yingwu Yin and Jinying Yuan
Polymer Chemistry 2013 vol. 4(Issue 4) pp:1216-1220
Publication Date(Web):06 Nov 2012
DOI:10.1039/C2PY20849K
Self-healing nanomaterials that respond to new stimuli sources are attractive. In particular, redox potential is one of the most universal and convenient stimuli in nature. Here we report utilization of ferrocene- and cyclodextrin-terminated monomers to form water-soluble AA-BB-type supramolecular polymers on the basis of host–guest interactions of ferrocene (Fc) and cyclodextrin (CD). These noncovalent polymers can further hierarchically assemble into one-dimensional supramolecular nanofiber architectures. The electrochemical-responsive Fc–CD host–guest connections endow these nanofibers with unique self-degradable and -healable features under redox potential control. Moreover, different redox conditions can exactly regulate the self-repairable rates of these nanostructures. It is anticipated that this supramolecular polymer model would open up a way for redox-tunable one-dimensional nanomaterials.
Co-reporter:Huijuan Zhang;Liao Peng;Yan Xin;Qiang Yan ;Jinying Yuan
Macromolecular Symposia 2013 Volume 329( Issue 1) pp:66-69
Publication Date(Web):
DOI:10.1002/masy.201300010
Summary
Different from the chemical structure and self-assembly behavior of traditional block copolymer, a homopolymer self-assembly approach with reversible linkage based on linker chemistry has been developed. The strategy could be used for the preparation of stimuli-responsive polymer networks with reversible linkers. A redox-responsive supramolecular hydrogel was obtained by two hydrophilic copolymers (poly(N, N'-dimethylacrylamide-r-glycidyl methacrylateglycidyl methacrylate) and poly(N, N'-dimethylacrylamide-r-hydroxyethyl methacrylateglycidyl methacrylate)) with β-CD and ferrocene pendent groups, respectively. The hydrogel exhibited gel-sol transition after the addition of an oxidizing agent FeCl3 and returned to its gel state when a reducing agent ascorbic acid was added. SEM observation showed that the hydrogel had a porous network structure. The host-guest interaction between β-CD and ferrocene was a dominant driving force for the formation of the hydrogel.
Co-reporter:Dr. Qiang Yan; Jianbo Wang;Dr. Yingwu Yin;Dr. Jinying Yuan
Angewandte Chemie 2013 Volume 125( Issue 19) pp:5174-5177
Publication Date(Web):
DOI:10.1002/ange.201300397
Co-reporter:Dr. Qiang Yan; Jianbo Wang;Dr. Yingwu Yin;Dr. Jinying Yuan
Angewandte Chemie 2013 Volume 125( Issue 19) pp:
Publication Date(Web):
DOI:10.1002/ange.201302126
Co-reporter:Dr. Qiang Yan; Jianbo Wang;Dr. Yingwu Yin;Dr. Jinying Yuan
Angewandte Chemie International Edition 2013 Volume 52( Issue 19) pp:
Publication Date(Web):
DOI:10.1002/anie.201302126
Co-reporter:Dr. Qiang Yan; Jianbo Wang;Dr. Yingwu Yin;Dr. Jinying Yuan
Angewandte Chemie International Edition 2013 Volume 52( Issue 19) pp:5070-5073
Publication Date(Web):
DOI:10.1002/anie.201300397
Co-reporter:Lilin Zhou, Jingjun Wu, Huijuan Zhang, Yan Kang, Jun Guo, Chong Zhang, Jinying Yuan and Xinhui Xing
Journal of Materials Chemistry A 2012 vol. 22(Issue 14) pp:6813-6818
Publication Date(Web):27 Feb 2012
DOI:10.1039/C2JM16778F
By the combination of fusion protein technology and nanoparticle surface modification technology, a maltose-modified magnetic support has been successfully developed for the integration of separation/purification, and immobilization of maltose binding protein–Heparinase I fusion enzyme (MBP–HepA) for enzymatic reaction and recycle. HepA is an important enzyme to degrade heparin and heparan sulfate to produce low molecular weight heparin (LMWH). This magnetic support may play an important role for process simplification and cost reduction on the industrial production of LMWH. Further, this magnetic support also can be used for the immobilization of other MBP fusion proteins, which implies that this magnetic support may have wide applications in biotechnology and enzyme engineering.
Co-reporter:Qiang Yan, Jun Hu, Rong Zhou, Yong Ju, Yingwu Yin and Jinying Yuan
Chemical Communications 2012 vol. 48(Issue 13) pp:1913-1915
Publication Date(Web):20 Dec 2011
DOI:10.1039/C2CC16921E
A class of dialkoxyanthracene-containing diblock copolymers is synthesized which possesses visible light-responsivity. These copolymers can self-assemble into a micellar structure in water. Green visible light (540 nm) is able to scissor these anthracene species and cleave the diblock copolymer into two fragments, inducing disassembly of the self-assembled micelles.
Co-reporter:Yan Xin and Jinying Yuan
Polymer Chemistry 2012 vol. 3(Issue 11) pp:3045-3055
Publication Date(Web):28 Jun 2012
DOI:10.1039/C2PY20290E
Schiff-base reactions are widely used in the field of chemistry. With many advantages, such as mild reaction conditions and high reaction rates, they were employed for protecting various functional groups and synthesizing a series of organic ligands. In polymer chemistry, they can serve as potential pH-responsive linkers in polymer chains because of their sensitive responses to changes in the pH value. With certain particular designs, the Schiff-base structure can cooperate with other reversible covalent bonds or supra-molecular interactions to form assemblies or gels, providing various functions and applications. This article aims to give a critical review of the recent literature on the Schiff-base reactions used in polymer chemistry and how they serve as a way of linking structures together. We will also cover some of the important developments on the functions and applications of these polymers.
Co-reporter:Hui-Juan Zhang;Yan Xin;Qiang Yan;Li-Lin Zhou;Liao Peng
Macromolecular Rapid Communications 2012 Volume 33( Issue 22) pp:1952-1957
Publication Date(Web):
DOI:10.1002/marc.201200439
Abstract
A photoresponsive microgel is designed by the combination of a noncovalent assembly strategy with a covalent cross-linking method. End-functionalized poly(ethylene glycol) with azobenzene [(PEG-(Azo)2)] was mixed with acrylate-modified β-CD (β-CD-MAA) to form photoresponsive inclusion complex through host–guest interaction. The above photoresponsive complex was cross-linked by thiol-functionalized PEG (PEG-dithiol) via Michael addition click reaction. The photoreversibility of resulted microgel was studied by TEM, UV–Vis spectroscopy, and 1H NMR measurements. The characterization results indicated that the reversible size changes of the microgel could be achieved by alternative UV–Vis irradiations with good repeatability.
Co-reporter:Hui-Juan Zhang;Yan Xin;Qiang Yan;Li-Lin Zhou;Liao Peng
Macromolecular Rapid Communications 2012 Volume 33( Issue 22) pp:
Publication Date(Web):
DOI:10.1002/marc.201290078
Co-reporter:Yan Kang;Jinying Yuan;Qiang Yan;Liyao Zheng ;Lilin Zhou
Polymers for Advanced Technologies 2012 Volume 23( Issue 2) pp:255-261
Publication Date(Web):
DOI:10.1002/pat.1863
Abstract
Well-defined β-cyclodextrin (β-CD)-appended biocompatible comb-copolymer ethyl cellulose-graft-poly (ε-caprolactone) (EC-g-PCL) was synthesized via the combination of ring-opening polymerization (ROP) and click chemistry. The resulting products were characterized by 1H NMR, FT-IR spectroscopy, and GPC. The synthesized comb-copolymer could assemble to micelles, with the surface covered by β-CD. The inclusion with ferrocene derivation was investigated by cyclic voltammetric (CV) experiments, which indicated the potential application of the micelles as nano-receptors for molecule recognization and controlled drug release. Copyright © 2011 John Wiley & Sons, Ltd.
Co-reporter:Lilin Zhou, Liyao Zheng, Jinying Yuan, Sizhu Wu
Materials Letters 2012 Volume 78() pp:166-169
Publication Date(Web):1 July 2012
DOI:10.1016/j.matlet.2012.03.020
Co-reporter:Huijuan Zhang, Qiang Yan, Yan Kang, Lilin Zhou, Hang Zhou, Jinying Yuan, Sizhu Wu
Polymer 2012 Volume 53(Issue 17) pp:3719-3725
Publication Date(Web):2 August 2012
DOI:10.1016/j.polymer.2012.05.059
A thermally reversible hydrogel composed of a three-arm star copolymer with a specific host β-cyclodextrin (β-CD) center has been developed. The synthesis of this star copolymer initiates with β-CD core, from which sequential polymerization of a temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) block and a hydrophilic poly(N,N-dimethylacrylamide) (PDMA) block as asymmetric arms (named β-CD-g-(PNIPAM-b-PDMA)3) is performed via RAFT protocol. Below the lower critical solution temperature (LCST) of PNIPAM segment, the polymer is of good water-solubility and exhibits a sol state. Upon thermal stimulus, free-standing hydrogels can be formed rapidly at sufficiently high concentrations. By comparing the sol–gel transition of the star polymer with that of its linear counterpart without this feature, we concluded that the special star-shape topology and the thermal-collapsed PNIPAM chains were responsible for this gelation behavior. The rheology measurements indicate the mechanical properties of the polymer hydrogels and the thermal reversibility of the sol–gel transition. Using Rhodamine B as a molecule to model a typical drug, we realize the favorable encapsulation and releasing process from the hydrogel, demonstrating that this star polymer has the potential to function as an injectable hydrogel for drug delivery and gene transport.Graphical abstract
Co-reporter:Lilin Zhou, Jinying Yuan and Yen Wei
Journal of Materials Chemistry A 2011 vol. 21(Issue 9) pp:2823-2840
Publication Date(Web):18 Nov 2010
DOI:10.1039/C0JM02172E
Superparamagnetic iron oxide nanoparticles have received great research attention due to their wide spectrum of potential applications. Core–shell structures with iron oxide nanoparticles as the core and with covalently grafted organic polymers as the shell, which has specific functions, such as biocompatibility, fluorescence, and biological activity have been synthesised. These nanostructured compounds could find numerous biomedical applications. This feature article provides a review on the synthetic methodologies for building such magnetic core–shell structures, and on their applications in targeted drug delivery, enhanced magnetic resonance imaging (MRI), enzyme immobilization, hyperthermia and biosensors. Promising future directions of this active research field are also discussed.
Co-reporter:Yan Kang, Lilin Zhou, Xia Li and Jinying Yuan
Journal of Materials Chemistry A 2011 vol. 21(Issue 11) pp:3704-3710
Publication Date(Web):31 Jan 2011
DOI:10.1039/C0JM03513K
β-Cyclodextrin-modified hybrid magnetic nanoparticles (Fe3O4@SiO2-PGMACD) were synthesized via the combination of atom transfer radical polymerization on the surfaces of silica coated iron oxide particles (Fe3O4@SiO2) and ring-opening reaction of epoxy groups. The feasibility of using Fe3O4@SiO2-PGMACD as separable immobilized catalyst and adsorbent was demonstrated. It was found: (1) the prepared Fe3O4@SiO2-PGMACD could be used as catalyst in substrate-selective oxidation of alcohols system and the catalytic efficiency was close to pure β-Cyclodextrin of equal quantity; (2) the resulting particles appeared remarkably dominant adsorption capacity compared with poly(glycidyl methacrylate) grafted magnetic nanoparticles (Fe3O4@SiO2-PGMA) in the removal of bisphenol A from aqueous solutions. The results suggest that the novel fabricated nanoparticles could serve as bifunctional materials in catalysis or adsorption and subsequently become potential multifunctional materials.
Co-reporter:Qiang Yan, Yan Xin, Rong Zhou, Yingwu Yin and Jinying Yuan
Chemical Communications 2011 vol. 47(Issue 34) pp:9594-9596
Publication Date(Web):16 Jun 2011
DOI:10.1039/C1CC12644J
Two homopolymers can orthogonally self-assemble into pseudo-copolymer based on terminal host–guest interactions, and these supramolecular copolymers further fabricate one-dimensional nanotubes in water. By applying alternate UV/visible light, the aggregates can reversibly assemble and disassemble by means of the association and disassociation of active connection.
Co-reporter:Lilin Zhou;Zhinan Cai;Jinying Yuan;Yan Kang;Weizhong Yuan;Dezhong Shen
Polymer International 2011 Volume 60( Issue 9) pp:1303-1308
Publication Date(Web):
DOI:10.1002/pi.3081
Abstract
Multifunctional hybrid nanoparticles, Fe3O4@poly[(2-dimethylamino)ethyl methacrylate]-block-poly(2-hydroxyethyl methacrylate)-graft-carbazole, with pH-responsivity, superparamagnetism and fluorescence for targeted drug delivery and release have been synthesized. The nanoparticles have a core-shell structure as determined from transmission electron microscopy, pH-responsivity as determined from hydrodynamic radius analysis, superparamagnetism as determined from vibrating sample magnetometry and fluorescence as determined from fluorescence spectroscopy and fluorescence microscopy. The release behavior of model drug progesterone indicates that the release rate can be effectively controlled by altering the pH of the environment. The multifunctional nanoparticles could be applied extensively in targeted drug delivery and release, and with fluorescence they can serve as efficient tracers to record magnetic targeting routes. Copyright © 2011 Society of Chemical Industry
Co-reporter:Qiang Yan;Rong Zhou;Changkui Fu;Dr. Huijuan Zhang; Yingwu Yin; Jinying Yuan
Angewandte Chemie International Edition 2011 Volume 50( Issue 21) pp:4923-4927
Publication Date(Web):
DOI:10.1002/anie.201100708
Co-reporter:Qiang Yan;Rong Zhou;Changkui Fu;Dr. Huijuan Zhang; Yingwu Yin; Jinying Yuan
Angewandte Chemie 2011 Volume 123( Issue 21) pp:5025-5029
Publication Date(Web):
DOI:10.1002/ange.201100708
Co-reporter:Qiang Yan, Jinying Yuan, Yan Kang, Zhinan Cai, Lilin Zhou and Yingwu Yin
Chemical Communications 2010 vol. 46(Issue 16) pp:2781-2783
Publication Date(Web):25 Feb 2010
DOI:10.1039/B926882K
A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the sensor displays an “isothermal” thermochromic point as an ultra-sensitive thermometer.
Co-reporter:Qiang Yan, Jinying Yuan, Yan Kang and Yingwu Yin
Polymer Chemistry 2010 vol. 1(Issue 4) pp:423-425
Publication Date(Web):16 Feb 2010
DOI:10.1039/C0PY00024H
Host molecules (α-CD) hierarchically thread onto the double grafts of the comb-copolymer EC-g-PCL-b-PEO from the outer block to the inner block in aqueous solution. Adjusting the molar ratio between α-CD and copolymer can induce these supramacromolecular complexes to dynamically and reversibly self-tune their fabrication from micelles (0-D) to cylinders (1-D) to vesicles (3-D) to sheets (2-D) like “living” assemblies.
Co-reporter:Mi Zhou;JinYing Yuan;WeiZhong Yuan;XiaoYin Hong;YingWu Yin
Science Bulletin 2010 Volume 55( Issue 14) pp:1376-1381
Publication Date(Web):2010 May
DOI:10.1007/s11434-010-0151-1
A core-shell hybrid nanostructure, a hard core of single-crystalline lanthanum hydroxide nanowires and a soft shell of brushes of poly (ɛ-caprolactone) (PCL), has been successfully prepared by ring-opening polymerization (ROP) on the surface of nanowires. Such special structures were proved by TEM images. Meanwhile, the thickness of polymer layers was measured. The chemical component and the grafted PCL quantity of the sample were characterized by FTIR and TGA, which provides a simple and universal method to functionalize non-carbon nanowires. The modified lanthanum hydroxide nanowires can be well-dispersed in good solvents for PCL.
Co-reporter:Weizhong Yuan, Jinying Yuan, Lilin Zhou, Sizhu Wu, Xiaoyin Hong
Polymer 2010 Volume 51(Issue 12) pp:2540-2547
Publication Date(Web):28 May 2010
DOI:10.1016/j.polymer.2010.04.016
Well-defined monodisperse Fe3O4@poly (2-hydroxyethyl methacrylate)-graft- poly(ε-caprolactone) (Fe3O4@PHEMA-g-PCL) magnetic nanoparticles with novel topological structure, i.e., with branched brush polymeric shell, were successfully prepared by the combination of atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Oleic acid stabilized monodisperse Fe3O4 nanoparticles were prepared by a convenient organic phase process and underwent a ligand exchange process with 2-bromo-2-methylpropionic acid (Br-MPA) to generate macroinitiator (Fe3O4@Br-MPA) for ATRP of 2-hydroxyethyl methacrylate (HEMA) to produce Fe3O4@poly(2-hydroxyethyl methacrylate) (Fe3O4@PHEMA). PCL segments were grafted from the side of PHEMA by the ROP of ε-caprolactone (CL) with the hydroxyl groups of PHEMA segments used as initiation centers, and then Fe3O4@PHEMA-g-PCL magnetic nanoparticles were obtained. PCL segments of Fe3O4@PHEMA-g-PCL possessed lower degree of crystallinity than that of linear PCL. Meanwhile, Fe3O4@PHEMA-g-PCL nanoparticles showed superparamagnetism and comparatively strong magnetization. In vitro degradation investigation indicated that the degradation rate of PCL segments in Fe3O4@PHEMA-g-PCL increased with the decrease of the length of PCL chains. The release behavior of model drug chlorambucil from the nanoparticles indicated that the rate of drug release could be adjusted by altering the chain-length of PCL segments.
Co-reporter:Lilin Zhou, Jinying Yuan, Weizhong Yuan, Mi Zhou, Sizhu Wu, Zhaolong Li, Xinhui Xing, Dezhong Shen
Materials Letters 2009 Volume 63(18–19) pp:1567-1570
Publication Date(Web):31 July 2009
DOI:10.1016/j.matlet.2009.03.030
A novel kind of hybrid nanoparticles, Fe3O4@poly(ε-caprolactone)-carbazole, i.e. Fe3O4@PCL-carbazole, was synthesized via surface-initiated ring-opening polymerization (ROP) from glycolic acid — functionalized Fe3O4, and N, N′-Dicyclohexylcarbodiimide (DCC) was used to combine carbazyl group to the hydroxyl group at the end of PCL. The organic polymers as the shell were obtained with a narrow molecular weight distribution. Superparamagnetism and fluorescence of the nanoparticles were investigated by vibrating sample magnetometry (VSM) and fluorescence spectra. The study of the release of model drug progesterone from the hybrid nanoparticles indicated that the drug was released slowly and steady-going. Combined with the advantage of superparamagnetism, biodegradability, biocompatibility and fluorescence, the hybrid nanoparticles could be used as novel potential carriers and applied extensively in targeted drug delivery and release.
Co-reporter:Qiang Yan, Jinying Yuan, Fengbo Zhang, Xiaofeng Sui, Xuming Xie, Yingwu Yin, Shanfeng Wang and Yen Wei
Biomacromolecules 2009 Volume 10(Issue 8) pp:
Publication Date(Web):July 22, 2009
DOI:10.1021/bm801313q
Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(ε-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.
Co-reporter:Qiang Yan, Jinying Yuan, Weizhong Yuan, Mi Zhou, Yingwu Yin and Caiyuan Pan
Chemical Communications 2008 (Issue 46) pp:6188-6190
Publication Date(Web):22 Oct 2008
DOI:10.1039/B814064B
Aqueous solution of micelles prepared from novel PS-b-PNIPAM with fluorescent group CEA at the junction between two blocks displays logical responsive switches on temperature and fluorescence; at lower temperature, stretching of PNIPAM chains causes high mobility of CEA leading to formation of more excimer species; at higher temperature, shrinking of PNIPAM chains isolates the fluorescent groups between the core and shell, resulting in fewer excimer species.
Co-reporter:Lilin Zhou, Weizhong Yuan, Jinying Yuan, Xiaoyin Hong
Materials Letters 2008 Volume 62(8–9) pp:1372-1375
Publication Date(Web):31 March 2008
DOI:10.1016/j.matlet.2007.08.057
Organic/inorganic hybrid materials have both the advantages of organic polymers and inorganic materials, and now have become a new hotspot in material science. We choose Poly((2-Dimethylamino)ethyl methacrylate) (PDMAEMA), which was grafted from the surface of silica nanoparticles via atom transfer radical polymerization (ATRP) to form pH and temperature stimuli-responsive hybrid nanoparticles. Thermogravimetric analysis (TGA) was used to estimate the content of linked organic compound, and transmission electron micrographs (TEM) was used to observe the shell–core structure of hybrid nanoparticles. Double stimuli-response was characterized with ZetaPALS Zeta Potential Analyzer. The results showed that the hybrid nanoparticles were successfully synthesized and had the expected double stimuli-response.
Co-reporter:Jinming Kuang, Jinying Yuan, Mi Zhou, Weizhong Yuan, Xiaofeng Sui, Zhaolong Li
Materials Letters 2008 Volume 62(Issue 25) pp:4078-4080
Publication Date(Web):30 September 2008
DOI:10.1016/j.matlet.2008.05.061
Lanthanum hydroxide nanowires were synthesized by hydrothermal method. To reduce the aggregation among lanthanum hydroxide nanowires, an effective surface modification method was proposed by grafting polyethylene glycol (PEG) onto lanthanum hydroxide nanowires. That is, the surface of lanthanum hydroxide nanowires was firstly treated with aminopropyltrimethoxysilane (APTMS), which is a silane coupling agent and introduces functional amino group onto the surface of lanthanum hydroxide nanowires, followed by grafting reaction with PEG-COCl. The obtained nanocomposite was characterized by Fourier Transform Infrared Spectroscopy (FT-IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). Results of FT-IR and TGA showed that the PEG chains had been covalently bonded to the surface of lanthanum hydroxide nanowires. It was found that the increase of molecular weight of the grafted PEG could increase the grafting percentage and hence promote the dispersibility.
Co-reporter:Weizhong Yuan;Jinying Yuan;Mi Zhou;Caiyuan Pan
Journal of Polymer Science Part A: Polymer Chemistry 2008 Volume 46( Issue 8) pp:2788-2798
Publication Date(Web):
DOI:10.1002/pola.22612
Abstract
Novel and well-defined pyrene-containing eight-arm star-shaped dendrimer-like copolymers were successfully achieved by combination of esterification, atom transfer radical polymerization (ATRP), divergent reaction, ring-opening polymerization (ROP), and coupling reaction on the basis of pentaerythritol. The reaction of pentaerythritol with 2-bromopropionyl bromide permitted ATRP of styrene (St) to form four-arm star-shaped polymer (PSt-Br)4. The molecular weights of these polymers could be adjusted by the variation of monomer conversion. Eight-hydroxyl star-shaped polymer (PSt-(OH)2)4 was produced by the divergent reaction of (PSt-Br)4 with diethanolamine. (PSt-(OH)2)4 was used as the initiator for ROP of ε-caprolactone (CL) to produce eight-arm star-shaped dendrimer-like copolymer (PSt-b-(PCL)2)4. The molecular weights of (PSt-b-(PCL)2)4 increased linearly with the increase of monomer. After the coupling reaction of hydroxyl-terminated (PSt-b-(PCL)2)4 with 1-pyrenebutyric acid, pyrene-containing eight-arm star-shaped dendrimer-like copolymer (PSt-b-(PCL-pyrene)2)4 was obtained. The eight-arm star-shaped dendrimer-like copolymers presented unique thermal properties and crystalline morphologies, which were different from those of linear poly(ε-caprolactone) (PCL). Fluorescence analysis indicated that (PSt-b-(PCL-pyrene)2)4 presented slightly stronger fluorescence intensity than 1-pyrenebutyric acid when the pyrene concentration of them was the same. The obtained pyrene-containing eight-arm star-shaped dendrimer-like copolymer has potential applications in biological fluorescent probe, photodynamic therapy, and optoelectronic devices. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2788–2798, 2008
Co-reporter:Xiaofeng Sui, Jinying Yuan, Mi Zhou, Jun Zhang, Haijun Yang, Weizhong Yuan, Yen Wei and Caiyuan Pan
Biomacromolecules 2008 Volume 9(Issue 10) pp:
Publication Date(Web):September 6, 2008
DOI:10.1021/bm800538d
Cellulose-graft-poly(N,N-dimethylamino-2-ethyl methacrylate) (cellulose-g-PDMAEMA) copolymers were prepared by homogeneous atom transfer radical polymerization (ATRP) under mild conditions. Cellulose macroinitiator was successfully synthesized by direct acylation of cellulose with 2-bromopropionyl bromide in a room temperature ionic liquid (RTIL), 1-allyl-3-methylimidazolium chloride. Copolymers were obtained via ATRP of N,N-dimethylamino-2-ethyl methacrylate (DMAEMA) with CuBr/ pentamethyldiethylenetriamine (PMDETA) as catalyst and N,N-dimethylformamide (DMF) as solvent without homopolymer byproduct. The grafting copolymers were characterized by 1H NMR, FT-IR, and TGA measurements. The results confirmed that PDMAEMA had been covalently bonded to cellulose backbone. Furthermore, the assemblies or aggregates formed by cellulose-g-PDMAEMA copolymers in water were studied at various concentrations, temperatures, and pH values by means of UV, DLS, TEM, and AFM. The results indicate that the copolymers had the pH- and temperature-responsive properties similar to the expected stimuli-responses by PDMAEMA. The synthetic strategy presented here could be employed in the preparation of other novel biomaterials from a variety of polysaccharides.
Co-reporter:Jinying Yuan;Xiaobin Huang;Weizhong Yuan;Xiaozhen Tang
Journal of Applied Polymer Science 2007 Volume 104(Issue 4) pp:2310-2317
Publication Date(Web):27 FEB 2007
DOI:10.1002/app.25699
Hexaarmed star-shaped hydroxyl-terminated poly(ε-caprolactone) (PCL) was successfully synthesized via the ring-opening polymerization of ε-caprolactone (CL) with hexakis[p-(hydroxymethyl)phenoxy]cyclotriphosphazene initiator and stannous octoate catalyst in bulk. The star-shaped PCL with hydroxy end groups could be used as a macroinitiator for block copolymerization with L-lactide (L-LA). The star-shaped triblock copolymer was synthesized by above-mentioned hydroxyl-terminated star-shaped diblock PCL-b-PLLA, D,L-lactide (D,L-LA), and glycolide (GA). IR, 1H NMR, and GPC analysis showed that the star-shaped block copolymers were successfully synthesized and the molecular weights and the unit composition of the star-shaped block copolymers were controlled by the molar ratios of monomer to initiator. The triblock copolymer presented a three-phase structure, namely, PCL crystalline, PLLA crystalline, and D,L-PLAGA amorphous domains, which made the triblock copolymer different from the diblock copolymer and star-shaped PCL in crystallizability and thermal behaviors. Then, the in vitro degradation behaviors of the copolymers were investigated. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 2310–2317, 2007
Co-reporter:Weizhong Yuan;Jinying Yuan;Mi Zhou;Xiaofeng Sui
Journal of Polymer Science Part A: Polymer Chemistry 2006 Volume 44(Issue 22) pp:6575-6586
Publication Date(Web):9 OCT 2006
DOI:10.1002/pola.21731
Novel and well-defined dendrimer-star, block-comb polymers were successfully achieved by the combination of living ring-opening polymerization and atom transfer radical polymerization on the basis of a dendrimer polyester. Star-shaped dendrimer poly(ϵ-caprolactone)s were synthesized by the bulk polymerization of ϵ-caprolactone with a dendrimer initiator and tin 2-ethylhexanoate as a catalyst. The molecular weights of the dendrimer poly(ϵ-caprolactone)s increased linearly with an increase in the monomer. The dendrimer poly(ϵ-caprolactone)s were converted into macroinitiators via esterification with 2-bromopropionyl bromide. The star-block copolymer dendrimer poly(ϵ-caprolactone)-block-poly(2-hydroxyethyl methacrylate) was obtained by the atom transfer radical polymerization of 2-hydroxyethyl methacrylate. The molecular weights of these copolymers were adjusted by the variation of the monomer conversion. Then, dendrimer-star, block-comb copolymers were prepared with poly(L-lactide) blocks grafted from poly(2-hydroxyethyl methacrylate) blocks by the ring-opening polymerization of L-lactide. The unique and well-defined structure of these copolymers presented thermal properties that were different from those of linear poly(ϵ-caprolactone). © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6575–6586, 2006
Co-reporter:Qiang Yan ; Jinying Yuan ; Zhinan Cai ; Yan Xin ; Yan Kang ;Yingwu Yin
Journal of the American Chemical Society () pp:
Publication Date(Web):June 21, 2010
DOI:10.1021/ja1027502
Two end-decorated homopolymers, poly(styrene)-β-cyclodextrin (PS-β-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-β-CD/PEO-Fc) in aqueous solutions based on the terminal host−guest interactions. These assemblies can further form supramolecular vesicles, and their assembly and disassembly behaviors can be reversibly switched by voltage through the reversible association and disassociation of the middle supramolecular connection. The vesicles possess an unprecedented property that their assembly or disassembly speed can be controlled by the applied voltage strength. Luminescence spectroscopy demonstrates that the vesicles act as nanocapsules carrying molecules within their hollow cavities and that the external voltage strength accurately regulates the drug release time.
Co-reporter:Anchao Feng, Qiang Yan, Huijuan Zhang, Liao Peng and Jinying Yuan
Chemical Communications 2014 - vol. 50(Issue 36) pp:NaN4742-4742
Publication Date(Web):2014/02/11
DOI:10.1039/C4CC00463A
The end-decorated homopolymer poly(ε-caprolactone)-ferrocene threaded onto a β-cyclodextrin-functionalized main-chain polymer can form a class of amphiphilic noncovalent graft copolymers based on the host–guest interactions of the terminal groups on the side chains. These new supramolecular polymer brushes can further self-assemble into micellar aggregates that exhibit reversible assembly and disassembly behavior under an electrochemical redox trigger, which opens up a new route to building dynamic block copolymer topologies.
Co-reporter:Anchao Feng, Chengbo Zhan, Qiang Yan, Bowen Liu and Jinying Yuan
Chemical Communications 2014 - vol. 50(Issue 64) pp:NaN8961-8961
Publication Date(Web):2014/06/17
DOI:10.1039/C4CC03156C
CO2-responsiveness is imported into amphiphilic block copolymers, poly[(N,N-diethylaminoethyl methacrylate)-b-(N-isopropylacrylamide)] (PDEAEMA-b-PNIPAM), and a system dual-responsive to CO2 and temperature is constructed. The copolymer self-assembles in aqueous solution, and undergoes phase transition when CO2 and temperature stimuli occur, since the stimuli give rise to the conversion of the hydrophilicity of both blocks. Combining CO2 and temperature as triggers, schizophrenic micelle to vesicle morphological transition of the polymer assemblies is controlled.
Co-reporter:Liao Peng, Anchao Feng, Meng Huo and Jinying Yuan
Chemical Communications 2014 - vol. 50(Issue 86) pp:NaN13014-13014
Publication Date(Web):2014/07/14
DOI:10.1039/C4CC05192K
Electrochemical stimuli have attracted much attention in recent years as they are simple, clean and can be widely applied in biological systems and material science. As one type of common guest molecules, ferrocene and its derivatives have been well studied with different host molecules, mainly including cyclodextrins, cucurbiturils, pillararenes and calixarenes. This article generally summarizes the recent work on the host–guest interactions between ferrocene derivatives and their host molecules, as well as various supramolecular systems based on these interactions. In addition, the development and outlook of electrochemical responsive systems are also discussed.
Co-reporter:Qiang Yan, Jun Hu, Rong Zhou, Yong Ju, Yingwu Yin and Jinying Yuan
Chemical Communications 2012 - vol. 48(Issue 13) pp:NaN1915-1915
Publication Date(Web):2011/12/20
DOI:10.1039/C2CC16921E
A class of dialkoxyanthracene-containing diblock copolymers is synthesized which possesses visible light-responsivity. These copolymers can self-assemble into a micellar structure in water. Green visible light (540 nm) is able to scissor these anthracene species and cleave the diblock copolymer into two fragments, inducing disassembly of the self-assembled micelles.
Co-reporter:Qiang Yan, Jinying Yuan, Yan Kang, Zhinan Cai, Lilin Zhou and Yingwu Yin
Chemical Communications 2010 - vol. 46(Issue 16) pp:NaN2783-2783
Publication Date(Web):2010/02/25
DOI:10.1039/B926882K
A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the sensor displays an “isothermal” thermochromic point as an ultra-sensitive thermometer.
Co-reporter:Qiang Yan, Jinying Yuan, Weizhong Yuan, Mi Zhou, Yingwu Yin and Caiyuan Pan
Chemical Communications 2008(Issue 46) pp:NaN6190-6190
Publication Date(Web):2008/10/22
DOI:10.1039/B814064B
Aqueous solution of micelles prepared from novel PS-b-PNIPAM with fluorescent group CEA at the junction between two blocks displays logical responsive switches on temperature and fluorescence; at lower temperature, stretching of PNIPAM chains causes high mobility of CEA leading to formation of more excimer species; at higher temperature, shrinking of PNIPAM chains isolates the fluorescent groups between the core and shell, resulting in fewer excimer species.
Co-reporter:Jun Guo, Niejun Wang, Jingjun Wu, Qiquan Ye, Chong Zhang, Xin-Hui Xing and Jinying Yuan
Journal of Materials Chemistry A 2014 - vol. 2(Issue 4) pp:NaN442-442
Publication Date(Web):2013/11/01
DOI:10.1039/C3TB21264E
CO2-responsive polymer poly(N,N-diethylaminoethylmethacrylate)-modified magnetic nanoparticles (Fe3O4@dye/SiO2–PDEAEMA) were synthesized by atom transfer radical polymerization from the surfaces of silica coated, dye-labelled iron oxide nanoparticles (Fe3O4@dye/SiO2). TEM, FT-IR, and TGA confirmed and quantified the grafted polymer brushes. The prepared magnetic nanoparticles (MNPs) were fluorescence labelled, as shown by the fluorescence spectra and fluorescence microscopy images. This indicated that the nanoparticles could be utilized as imaging probes to monitor the movement of biological cells or other systems. The PDEAEMA polymer brushes on the surface of MNPs endowed them with a protein adsorption ability. The polymer was also CO2-responsive, so it was a CO2-triggered reversible protein adsorption/release material, which was demonstrated by the bovine serum albumin (BSA) adsorption experiments. The results indicated that the reversible adsorption/release of protein by bubbling CO2 and N2 alternately was easy to achieve.
Co-reporter:Lilin Zhou, Jinying Yuan and Yen Wei
Journal of Materials Chemistry A 2011 - vol. 21(Issue 9) pp:NaN2840-2840
Publication Date(Web):2010/11/18
DOI:10.1039/C0JM02172E
Superparamagnetic iron oxide nanoparticles have received great research attention due to their wide spectrum of potential applications. Core–shell structures with iron oxide nanoparticles as the core and with covalently grafted organic polymers as the shell, which has specific functions, such as biocompatibility, fluorescence, and biological activity have been synthesised. These nanostructured compounds could find numerous biomedical applications. This feature article provides a review on the synthetic methodologies for building such magnetic core–shell structures, and on their applications in targeted drug delivery, enhanced magnetic resonance imaging (MRI), enzyme immobilization, hyperthermia and biosensors. Promising future directions of this active research field are also discussed.
Co-reporter:Yan Kang, Lilin Zhou, Xia Li and Jinying Yuan
Journal of Materials Chemistry A 2011 - vol. 21(Issue 11) pp:NaN3710-3710
Publication Date(Web):2011/01/31
DOI:10.1039/C0JM03513K
β-Cyclodextrin-modified hybrid magnetic nanoparticles (Fe3O4@SiO2-PGMACD) were synthesized via the combination of atom transfer radical polymerization on the surfaces of silica coated iron oxide particles (Fe3O4@SiO2) and ring-opening reaction of epoxy groups. The feasibility of using Fe3O4@SiO2-PGMACD as separable immobilized catalyst and adsorbent was demonstrated. It was found: (1) the prepared Fe3O4@SiO2-PGMACD could be used as catalyst in substrate-selective oxidation of alcohols system and the catalytic efficiency was close to pure β-Cyclodextrin of equal quantity; (2) the resulting particles appeared remarkably dominant adsorption capacity compared with poly(glycidyl methacrylate) grafted magnetic nanoparticles (Fe3O4@SiO2-PGMA) in the removal of bisphenol A from aqueous solutions. The results suggest that the novel fabricated nanoparticles could serve as bifunctional materials in catalysis or adsorption and subsequently become potential multifunctional materials.
Co-reporter:Lilin Zhou, Jingjun Wu, Huijuan Zhang, Yan Kang, Jun Guo, Chong Zhang, Jinying Yuan and Xinhui Xing
Journal of Materials Chemistry A 2012 - vol. 22(Issue 14) pp:NaN6818-6818
Publication Date(Web):2012/02/27
DOI:10.1039/C2JM16778F
By the combination of fusion protein technology and nanoparticle surface modification technology, a maltose-modified magnetic support has been successfully developed for the integration of separation/purification, and immobilization of maltose binding protein–Heparinase I fusion enzyme (MBP–HepA) for enzymatic reaction and recycle. HepA is an important enzyme to degrade heparin and heparan sulfate to produce low molecular weight heparin (LMWH). This magnetic support may play an important role for process simplification and cost reduction on the industrial production of LMWH. Further, this magnetic support also can be used for the immobilization of other MBP fusion proteins, which implies that this magnetic support may have wide applications in biotechnology and enzyme engineering.
Co-reporter:Qiang Yan, Yan Xin, Rong Zhou, Yingwu Yin and Jinying Yuan
Chemical Communications 2011 - vol. 47(Issue 34) pp:NaN9596-9596
Publication Date(Web):2011/06/16
DOI:10.1039/C1CC12644J
Two homopolymers can orthogonally self-assemble into pseudo-copolymer based on terminal host–guest interactions, and these supramolecular copolymers further fabricate one-dimensional nanotubes in water. By applying alternate UV/visible light, the aggregates can reversibly assemble and disassemble by means of the association and disassociation of active connection.
Co-reporter:Jun Guo, Niejun Wang, Liao Peng, Jingjun Wu, Qiquan Ye, Anchao Feng, Zhipeng Wang, Chong Zhang, Xin-Hui Xing and Jinying Yuan
Journal of Materials Chemistry A 2016 - vol. 4(Issue 22) pp:NaN4016-4016
Publication Date(Web):2016/05/03
DOI:10.1039/C6TB00259E
Electrochemical stimulus is a clean and simple choice of stimulating source in the field of stimuli-responsive materials. Herein, we report an electrochemically-responsive hybrid assembly of magnetic nanoparticles (Fe3O4@SiO2-PGMA-CD) and polyethylene glycol-Fc (PEG-Fc) based on the host–guest interaction between β-cyclodextrin and ferrocene groups. Through electrochemical control, the hydrophilic polymer chains can be reversibly linked to or dropped off from the surface of the magnetic nanoparticles. Thus, the hydrophobic property of the surface together with the protein adsorption ability of the magnetic nanoparticles can be conveniently adjusted by voltages applied. A reversible protein adsorption/release transition from this novel hybrid material has been realized, demonstrated by the bovine serum albumin adsorption experiment. Therefore, an elegant material is introduced to achieve electrochemically-controlled reversible magnetic separation of proteins.
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