2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile

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CAS: 23917-22-8
MF: C10H12N2S
MW: 192.28068
Synonyms: 2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile

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Yanlong Gu

Huazhong University of Science and Technology
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Co-reporter: Rongxian Bai, Ping Liu, Jian Yang, Changhui Liu, and Yanlong Gu
pp: 1292
Publication Date(Web):May 11, 2015
DOI: 10.1021/sc500763q
Substituted 2-aminothiophenes were synthesized through Gewald reaction by using an easily available solid base catalyst, sodium aluminate. Cost-effectiveness, mild and environmentally benign conditions, and excellent catalytic performance are the features of this system. Furthermore, the NaAlO2 catalyst can be swimmingly recovered and reused in this reaction.Keywords: 2-Aminothiophenes; Gewald reaction; Multicomponent reaction; NaAlO2

RongXian Bai

Huazhong University of Science and Technology
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Bo Li

China Pharmaceutical University
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Daxin Shi

Beijing Institute of Technology
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Qi Zhang

Beijing Institute of Technology
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