Co-reporter:Burkhardt I. Wilke, Mark H. Dornan, Jon Yeung, Christopher N. Boddy, Atahualpa Pinto
Tetrahedron Letters 2014 Volume 55(Issue 16) pp:2600-2602
Publication Date(Web):16 April 2014
DOI:10.1016/j.tetlet.2014.02.067
Symmetric diols are useful compounds in the synthesis of natural products, their value often dependent on their successful monoprotection. A general and simple method for the monosilylation of symmetrical primary and secondary diols is reported. The method exploits the solubility differential of diols and their monosilylated counterparts in a binary hexanes/acetonitrile solvent system.Graphical abstract
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