GuangYu Xu

Name: 徐广宇; GuangYu Xu

Organization: Hunan Normal University

Department: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering

Title: Professor

Chemicals
References

Nucleophilic Functionalizations of Aniline Derivatives: Aromatic Pummerer Reaction for Umpolung Halogenation and Hydroxylation on Benzene Ring

Co-reporter:Xingping Bao, Jinzhong Yao, Hongwei Zhou, and Guangyu Xu

Organic Letters November 3, 2017 Volume 19(Issue 21) pp:5780-5780

Publication Date(Web):October 24, 2017

DOI:10.1021/acs.orglett.7b02720

In this paper, a metal-free protocol of nucleophilic ortho-halogenation and hydroxylation of anilines via an aromatic Pummerer process is reported.

Ac2O/K2CO3/DMSO: an efficient and practical reagent system for the synthesis of nitriles from aldoximes

Co-reporter:Yaoping Song, Dongguo Shen, Qinghua Zhang, Bo Chen, Guangyu Xu

Tetrahedron Letters 2014 Volume 55(Issue 3) pp:639-641

Publication Date(Web):15 January 2014

DOI:10.1016/j.tetlet.2013.11.079

The transformation of aldoximes to nitriles using acetic anhydride as dehydration agent under mild reaction conditions is reported. The reaction, which proceeds under weak alkaline condition, allows for the conversion of a range of aldoximes including aromatic aldoximes, alphatic aldoximes, and heterocyclic aldoximes in good to excellent yields. This method has also been successfully applied to the synthesis of calcium channel blocker nilvadipine in pilot scale.

Synthesis and cytotoxic activity of 3-phenyl-4-substituted-β-carbolines

Co-reporter:Liu Liu, Ying Ying Xu, Ze Qi Yang, Jian Nan Xiang, Guang Yu Xu

Chinese Chemical Letters 2012 Volume 23(Issue 11) pp:1230-1232

Publication Date(Web):November 2012

DOI:10.1016/j.cclet.2012.09.010

A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.

A convenient synthesis of oxazolidinone derivatives linezolid and eperezolid from (S)-glyceraldehyde acetonide

Co-reporter:Guangyu Xu;Yi Zhou;Chunhao Yang;Yuyuan Xie

Heteroatom Chemistry 2008 Volume 19( Issue 3) pp:316-319

Publication Date(Web):

DOI:10.1002/hc.20435

Abstract

A new convenient method for the synthesis of oxazolidinone antibacterials Linezolid and Eperezolid from readily available (S)-glyceraldehyde acetonide was developed. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH₄ and 4 Å sieve, followed by hydrolysis and regioselective cyclization. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:316–319, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20435

A practical Δ1-dehydrogenation of Δ4-3-keto-steroids with DDQ in the presence of TBDMSCl at room temperature

Co-reporter:Kaixiong Chen, Chang Liu, Le Deng, Guangyu Xu

Steroids (July 2010) Volume 75(Issue 7) pp:513-516

Publication Date(Web):1 July 2010

DOI:10.1016/j.steroids.2010.03.002

A mild and efficient Δ1-dehydrogenation of Δ4-3-keto-steroids with DDQ in the presence of tertbutyldimethylchlorosilane at room temperature was developed.