Co-reporter:Xingjiang Liu, Fengpei Qi, Yuanan Su, Wenqiang Chen, Lei Yang and Xiangzhi Song
Journal of Materials Chemistry A 2016 vol. 4(Issue 19) pp:4320-4326
Publication Date(Web):29 Mar 2016
DOI:10.1039/C5TC03977K
A novel red emitting fluorescent probe for the detection of thiophenol in aqueous medium has been developed. This probe displays an instantaneous response (within seconds) and reaches a plateau within 2 min. It also exhibits a 129 nm Stokes shift and a low detection limit (8.2 nM, based on S/N = 3) in detecting thiophenol. Furthermore, the practical utility of this probe for the selective detection of thiophenol has been successfully demonstrated in both real water samples and living cells.
Co-reporter:Wenqiang Chen, Qian Fang, Dalei Yang, Hongyan Zhang, Xiangzhi Song, and James Foley
Analytical Chemistry 2015 Volume 87(Issue 1) pp:609
Publication Date(Web):November 19, 2014
DOI:10.1021/ac503281z
On the basis of a unique nucleophilic addition reaction, a novel water-soluble broadly emitting (500–700 nm) fluorescent Probe 1 was developed for the rapid detection of SO2 derivatives in aqueous media. The positively-charged benzopyrylium moiety in Probe 1 provides both excellent water solubility, making this probe applicable in 100% aqueous environments, and the ability to function as a fluorescence quencher of the coumarin moiety. Probe 1 generates a nearly instantaneous strong fluorescence signal in response to SO2 derivatives having an 8.3 nM detection limit for bisufite. The resulting Probe 1–sulfite adduct emits in the green/red spectral region (λmax = 585 nm) with a large Stokes shift (139 nm). The probe exhibits excellent selectivity toward SO2 derivatives over other potential interfering agents including reactive sulfur-containing species. Importantly, we demonstrate that Probe 1 can be used for the real-time sensing and bioimaging of SO2 derivatives in living cells.
Co-reporter:Wenqiang Chen, Song Chen, Bingjiang Zhou, Hongbo Wang, Xiangzhi Song, Hongyan Zhang
Dyes and Pigments 2015 Volume 113() pp:596-601
Publication Date(Web):February 2015
DOI:10.1016/j.dyepig.2014.09.035
•Based on ESIPT and PET mechanisms, a novel fluorescent probe has been developed.•In aqueous solution, the probe displays high sensitivity and good selectivity to H2S.•This probe has been successfully applied to detect intracellular H2S in living cellsThe O-2,4-dinitrobenzensulfonate of 1,3-bis(bispyridin-2ylimino)isoindolin-4-ol has been developed as a novel red-emitting fluorescent probe for the detection of H2S. The dinitrobenzenesulfonate moiety in the probe both prohibits the excited state intramolecular proton transfer process and produces a photo-induced electron transfer process, which renders the probe non-fluorescent in the absence of the analyte. In the presence of H2S a specific H2S-mediated cleavage reaction converts the probe into 1,3-bis(bispyridin-2-ylimino)isoindolin-4-ol which exhibits a strong red fluorescence with a large Stokes shift (218 nm) via an excited state intramolecular proton transfer process upon excitation. It's noteworthy that this new probe shows good selectivity and sensitivity to H2S over glutathione, cysteine and homocysteine. Moreover successful detection and imaging of intracellular H2S in living cells was achieved. To our knowledge this is the first application of this type of fluorescent probe for intracellular H2S detection.Utilizing 2,4-dinitrobenzensulfonyl unit (DNBS) as a recognition group, a novel red-emitting fluorescent probe, BPI-DNBS, was developed for the selective detection of H2S with a 218 nm Stokes shift. It's noteworthy that this H2S fluorescent probe displays a good selectivity against biothiols, which makes it successful to image intracellular H2S in living cells.
Co-reporter:Xingjiang Liu, Li Gao, Liu Yang, Lifen Zou, Wenqiang Chen and Xiangzhi Song
RSC Advances 2015 vol. 5(Issue 24) pp:18177-18182
Publication Date(Web):03 Feb 2015
DOI:10.1039/C5RA00255A
A phthalimide-based dye, probe 1, was developed as a novel fluorescent probe for thiol detection with excellent selectivity and high sensitivity based on the combination of photo induced electron transfer (PET) and excited state intramolecular proton transfer (ESIPT) mechanisms. The probe can detect thiols quantitatively and selectively with a large Stokes shift (161 nm) and the detection limit (S/N = 3) is as low as 0.8 nM. Furthermore, this probe was successfully used for imaging thiols in living SH-SY5Y cells.
Co-reporter:Liu Yang, Xingjiang Liu, Li Gao, Fengpei Qi, Huihui Tian and Xiangzhi Song
RSC Advances 2015 vol. 5(Issue 119) pp:98154-98159
Publication Date(Web):11 Nov 2015
DOI:10.1039/C5RA19081A
A phthalimide-based fluorescent probe for hydrogen sulfide has been developed with high sensitivity and excellent selectivity. Upon treatment with hydrogen sulfide, this probe displays a strong fluorescence enhancement (196-fold) with a large Stokes shift (105 nm). Moreover, the potential application of using this probe in biological systems has been demonstrated by imaging hydrogen sulfide in living cells.
Co-reporter:Qian Fang;Qian Liu;Xiangzhi Song;Jian Kang
Luminescence 2015 Volume 30( Issue 8) pp:1280-1284
Publication Date(Web):
DOI:10.1002/bio.2893
Abstract
An aqueous fluorescent probe, 1, was developed for the rapid detection of Hg2+ with high sensitivity and excellent selectivity. Upon the addition of Hg2+ in pure aqueous media, the Hg2+-mediated hydrolysis of vinyl ether and subsequent cyclization reactions converted probe 1 into the corresponding iminocoumarin dye, which is strongly fluorescent when excited. The application of this probe for the detection of intracellular Hg2+ was successfully demonstrated in living cells. Copyright © 2015 John Wiley & Sons, Ltd.
Co-reporter:Xingjiang Liu, Liu Yang, Li Gao, Wenqiang Chen, Fengpei Qi, Xiangzhi Song
Tetrahedron 2015 Volume 71(Issue 43) pp:8285-8289
Publication Date(Web):28 October 2015
DOI:10.1016/j.tet.2015.08.074
A phthalimide-based fluorescent probe for the detection of thiophenol was developed based on the combination of photo-induced electron transfer (PET) and excited-state intramolecular proton transfer (ESIPT) mechanisms. This probe displays high sensitivity and good selectivity toward thiophenol with a large Stokes shift (161 nm) and a low detection limit (3.5 nM, based on S/N=3). Furthermore, the applications of this probe for quantitative detection of thiophenol in real water samples and imaging intracellular thiophenol in living cells were successfully demonstrated.
Co-reporter:Peng Hou, Song Chen, Hongbo Wang, Jianxiu Wang, Kislon Voitchovsky and Xiangzhi Song
Chemical Communications 2014 vol. 50(Issue 3) pp:320-322
Publication Date(Web):24 Oct 2013
DOI:10.1039/C3CC46630B
A novel red emitting fluorescent probe exhibiting a 143 nm Stokes shift for the detection of fluoride ions in an aqueous solution was developed. The probe displays a rapid response, high selectivity and good sensitivity towards F−. Application of the probe for the selective detection of intracellular F− has been successfully demonstrated in living cells.
Co-reporter:Chuan-Hua Li, Xiang-Zhi Song, Jian-Hong Jiang, Hui-Wen Gu, Li-Ming Tao, Ping Yang, Xu Li, Sheng-Xiong Xiao, Fei-Hong Yao, Wen-Qi Liu, Jin-Qi Xie, Meng-Na Peng, Lan Pan, Xi-Bin Wu, Chao Jiang, Song Wang, Man-Fen Xu, Qiang-Guo Li
Thermochimica Acta 2014 Volume 581() pp:118-122
Publication Date(Web):10 April 2014
DOI:10.1016/j.tca.2014.02.021
•A new mononuclear Schiff base praseodymium complex was synthesized.•Based on Hess's law, thermochemical cycles of two reactions were designed.•The dissolution enthalpies were measured by a solution–reaction calorimeter.•The standard molar enthalpy of formation of the complex was calculated.The title complex [Pr(H2vanen)(NO3)2(H2O)2·NO3] was synthesized reacting of Valen Schiff-base ligand [H2vanen = N,N′-ethylene-bis(3-methoxysalicylideneimine)] and Pr(NO3)3·6H2O in ethanol at 60 °C. The complex was crystallized in the monoclinic crystal system with space group P21/c. The coordination polyhedron of Pr(III) ion was consisted of two bidentate nitrate ions, two molecules of water and one ligand which coordinated through oxygen atoms of the two phenolic and methoxy groups. After designing two reasonable thermochemical cycles according to Hess's law, the calorimetric experiments were conducted using isoperibol solution–reaction calorimeter at a constant temperature of 298.15 K. The standard molar enthalpy changes of two reactions were determined to be ΔrHmθ(1a)=−(51.94±1.26) kJ mol−1 and ΔrHmθ(1b)=−(8.62±1.34) kJ mol−1. Then the standard molar enthalpies of formation of the ligand and the title complex were calculated to be ΔfHmθ [H2vanen(s), 298.15 K] = −(517.75 ± 2.36) kJ mol−1 and ΔfHmθ [Pr(H2vanen)(NO3)2(H2O)2·NO3 (s), 298.15 K] = −(2454.8 ± 2.7) kJ mol−1, respectively. The rationality of two thermochemical cycles was verified by UV spectra and refractive indexes.
Co-reporter:Peng Hou;Song Chen;Xiangzhi Song
Luminescence 2014 Volume 29( Issue 5) pp:423-426
Publication Date(Web):
DOI:10.1002/bio.2564
ABSTRACT
A colorimetric and turn-on fluorescent probe for fluoride ions, tert-butyldimethylsilane 6-acetyl-2-naphtholate, was readily synthesized from 6-acetyl-2-naphthol and tert-butyldimethylchlorosilane (TBSCl). The probe exhibits high sensitivity and good selectivity for fluoride ions in acetonitrile. The inherent mechanism involves the cleavage of the Si–O bond in the probe, which induced yellow color formation and prominent fluorescence enhancement. Copyright © 2013 John Wiley & Sons, Ltd.
Co-reporter:Peng Hou;Song Chen;Kislon Voitchovsky;Xiangzhi Song
Luminescence 2014 Volume 29( Issue 7) pp:749-753
Publication Date(Web):
DOI:10.1002/bio.2616
ABSTRACT
A colorimetric and ratiometric fluorescent sulfite probe, the levulinate of 4-hydroxynaphthalimide, was successfully synthesized from 4-hydroxy-naphthalimide and levulinic acid. Through sulfite-mediated intramolecular cleavage, the probe was converted into 4-hydroxynaphthalimide, which when excited at 450 nm, displayed a large Stokes shift due to the intramolecular charge transfer process. The probe exhibited high selectivity and sensitivity towards sulfite over other typical anionic species (F–, Cl–, Br–, I–, HPO42–, SO42–, NO3–, AcO–, ClO4–, HCO3–) in HEPES-buffered solution (25 mm, pH 7.4, 50% acetonitrile, v/v). Copyright © 2013 John Wiley & Sons, Ltd.
Co-reporter:Song Chen, Peng Hou, James W. Foley and Xiangzhi Song
RSC Advances 2013 vol. 3(Issue 16) pp:5591-5596
Publication Date(Web):05 Feb 2013
DOI:10.1039/C3RA23057K
The ester derived from picolinic acid and 4-hydroxynaphthalimide has been developed as a colorimetric and ratiometric fluorescent probe for the detection of Cu2+. Upon exposure to Cu2+ in a buffered solution, the probe displays a large red shift both in its absorption (110 nm) and emission (143 nm) spectra. This novel probe has a high sensitivity and an excellent selectivity for Cu2+ ions over competing metal ions (K+, Na+, Zn2+, Ni2+, Mn2+, Mg2+, Ca2+, Hg2+, Cd2+, Pb2+, Fe2+, Co2+, Ba2+, Ag+ and Fe3+). Most importantly, this new picolinate probe can successfully detect Cu2+ in living cells.
Co-reporter:Song Chen, Peng Hou, Jianxiu Wang and Xiangzhi Song
RSC Advances 2012 vol. 2(Issue 29) pp:10869-10873
Publication Date(Web):12 Sep 2012
DOI:10.1039/C2RA21471G
The levulinate ester of 2-(benzothiazol-2-yl)phenol, 1, has been developed as a ratiometric fluorescent probe for identifying and quantitating sulfite anions. The mechanism of action is based on the sulfite-triggered intramolecular cleavage of the levulinate moiety to give 1 which, when excited with 310 nm light, decays to its ground state via an excited state intramolecular proton transfer (ESIPT) mediated pathway. We show that the intensity of the ESIPT fluorescent signal relative to that of 1 is proportional to sulfite concentration. This new probe shows good selectivity and high sensitivity for sulfite over other typically encountered anions (F−, Cl−, Br−, I−, HPO42−, SO42−, NO3−, AcO−, ClO4−, N3−, HCO3−) when measured in CH3CN/H2O (50:50, v/v) solution.
Co-reporter:Xingjiang Liu, Fengpei Qi, Yuanan Su, Wenqiang Chen, Lei Yang and Xiangzhi Song
Journal of Materials Chemistry A 2016 - vol. 4(Issue 19) pp:NaN4326-4326
Publication Date(Web):2016/03/29
DOI:10.1039/C5TC03977K
A novel red emitting fluorescent probe for the detection of thiophenol in aqueous medium has been developed. This probe displays an instantaneous response (within seconds) and reaches a plateau within 2 min. It also exhibits a 129 nm Stokes shift and a low detection limit (8.2 nM, based on S/N = 3) in detecting thiophenol. Furthermore, the practical utility of this probe for the selective detection of thiophenol has been successfully demonstrated in both real water samples and living cells.
Co-reporter:Peng Hou, Song Chen, Hongbo Wang, Jianxiu Wang, Kislon Voitchovsky and Xiangzhi Song
Chemical Communications 2014 - vol. 50(Issue 3) pp:NaN322-322
Publication Date(Web):2013/10/24
DOI:10.1039/C3CC46630B
A novel red emitting fluorescent probe exhibiting a 143 nm Stokes shift for the detection of fluoride ions in an aqueous solution was developed. The probe displays a rapid response, high selectivity and good sensitivity towards F−. Application of the probe for the selective detection of intracellular F− has been successfully demonstrated in living cells.
![L-gamma-glutamyl-N-[S-(7-nitro-2,1,3-benzoxadiazol-4-yl)-L-cysteinyl]glycine](http://img.cochemist.com/ccimg/35900/35841-75-9.png)
![L-gamma-glutamyl-N-[S-(7-nitro-2,1,3-benzoxadiazol-4-yl)-L-cysteinyl]glycine](http://img.cochemist.com/ccimg/35900/35841-75-9_b.png)
