Changsheng Yao

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Organization: Xuzhou Normal University

Department: 1 School of Chemistry and Engineering, Key Laboratory of Biotechnology for Medicinal Plants

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Chemicals
References

NHC-catalyzed cascade synthesis of 1-substituted 4-aryl-tetrahydroquinoline-2,5-diones

Co-reporter:Changsheng Yao, Weihui Jiao, Zhaoxin Xiao, Rui Liu, Tuanjie Li, Chenxia Yu

Tetrahedron 2013 69(3) pp: 1133-1137

Publication Date(Web):

DOI:10.1016/j.tet.2012.11.052

One-pot solvent-free synthesis of quinolines by C–H activation/C–C Bond formation catalyzed by recyclable iron(III) triflate

Co-reporter:Changsheng Yao, Bingbin Qin, Honghong Zhang, Jun Lu, Donglin Wang and Shujiang Tu

RSC Advances 2012 vol. 2(Issue 9) pp:3759-3764

Publication Date(Web):30 Jan 2012

DOI:10.1039/C2RA20172K

A novel application of highly stable Fe(OTf)3 as an efficient catalyst for carbon–carbon bond formation via the activation of a terminal alkyne C–H bond under solvent-free conditions is described. Notably, this protocol of green synthesis, which produced quinolines from the reaction of amines, aldehydes and terminal aryl alkynes, shows attractive characteristics including concise one-pot conditions, high atom economy, very limited energy consumption, and the sequential catalytic process requires only a catalytic (5 mol%) amount of Fe(OTf)3 with short reaction periods (3 h). Meanwhile, the catalyst was easily recovered from the reaction system and reused smoothly with only a little loss of activity.

Solvent-Free Synthesis of 2-(Phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid

Co-reporter:Shide Shen;Weihua Yang;Chenxia Yu;Tuanjie Li

Journal of Heterocyclic Chemistry 2012 Volume 49( Issue 5) pp:1033-1037

Publication Date(Web):

DOI:10.1002/jhet.912

A series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.

N-Heterocyclic Carbene Catalyzed Reactions of -Bromo-,-unsaturated Aldehydes/,-Dibromoaldehydes with 1,3-Dinucleophilic Reagents

Co-reporter:Dr. Changsheng Yao;Donglin Wang;Jun Lu;Dr. Tuanjie Li;Weihui Jiao; Chenxia Yu

Chemistry - A European Journal 2012 Volume 18( Issue 7) pp:1914-1917

Publication Date(Web):

DOI:10.1002/chem.201103358

NHC triggered cascade metal-free synthesis of 2,3-diarylated indoles under solvent-free conditions

Co-reporter:Changsheng Yao, Donglin Wang, Jun Lu, Bingbin Qin, Honghong Zhang, Tuanjie Li, Chenxia Yu

Tetrahedron Letters 2011 Volume 52(Issue 46) pp:6162-6165

Publication Date(Web):16 November 2011

DOI:10.1016/j.tetlet.2011.09.041

A new cascade strategy to the synthesis of 2,3-diarylated indoles via the metal-free reaction of aryl aldehyde and aryl amine triggered by N-heterocyclic carbene (NHC) under solvent-free conditions, has been disclosed. The protocol has the advantages of easy work-up, high yields, wide application scope, and an environmentally benign procedure compared with the reported methods.A new cascade strategy to the synthesis of 2,3-disubstituted indoles via the metal-free reaction of aryl aldehyde and aryl amine triggered by N-heterocyclic carbene (NHCs) under solvent-free conditions, has been disclosed. The protocol has the advantages of easy work-up, high yields, wide application scope, and an environmentally benign procedure compared with the reported methods.

Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener

Co-reporter:Tuanjie Li, Xiaodong Feng, Changsheng Yao, Chenxia Yu, Bei Jiang, Shujiang Tu

Bioorganic & Medicinal Chemistry Letters 2011 Volume 21(Issue 1) pp:453-455

Publication Date(Web):1 January 2011

DOI:10.1016/j.bmcl.2010.10.127

A series of thieno[3,2-b]quinoline derivatives designed based on A-278637 scaffold, were synthesized efficiently via one-pot three-component reaction under solvent-free and catalyst-free conditions. This work provides a new compound library with potential biological activity for biomedical screening.A series of thieno[3,2-b]quinoline derivatives designed based on A-278637 scaffold, were synthesized efficiently via one-pot three-component reaction under solvent-free and catalyst-free conditions. This work provides a new compound library with potential biological activity for biomedical screening.

A Facile One-Pot Three-Component Synthesis of 5-(Trifluoromethyl)-4,7-dihydro-[1,2,4]-triazolo[1,5-a]pyrimidine Derivatives in Ionic Liquid

Co-reporter:Tuanjie Li;Song Lei;Chenxia Yu;Shujiang Tu

Chinese Journal of Chemistry 2011 Volume 29( Issue 11) pp:2427-2432

Publication Date(Web):

DOI:10.1002/cjoc.201180412

Abstract

An efficient one-pot synthesis of 5-(trifluoromethyl)-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-1,2,4-triazole and ethyl 4,4,4-trifluoro-3-oxobutanoate or 4,4,4-trifluoro-1-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.

One-pot Combinatorial Synthesis of Benzo[4,5]imidazo-[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one Derivatives

Co-reporter:Shide Shen;Honghong Zhang;Weihua Yang;Chenxia Yu

Chinese Journal of Chemistry 2011 Volume 29( Issue 8) pp:1727-1731

Publication Date(Web):

DOI:10.1002/cjoc.201180308

Abstract

A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]imidazol-2-amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.

Solvent-free three-component synthesis of 7-aryl-1,1-dioxothieno[3,2-b]pyran derivatives catalyzed by ammonium acetate

Co-reporter:Changsheng Yao;Xiaodong Feng;Cuihua Wang;Bei Jiang;Chenxia Yu;Xiangshan Wang;Tuanjie Li ;Shujiang Tu

Journal of Heterocyclic Chemistry 2011 Volume 48( Issue 5) pp:1111-1116

Publication Date(Web):

DOI:10.1002/jhet.696

Abstract

An efficient synthesis of 7-aryl-1,1-dioxothieno[3,2-b]pyran derivatives via the reaction of aryl aldehyde, tetrahydrothiophene-3-one-1,1-dioxide and malononitrile or ethyl 2-cyanoacetate was performed at room temperature catalyzed by ammonium acetate under solvent-free conditions. Compared with the conventional methods, this protocol features mild reaction conditions, high yields, and eco-friendliness. J. Heterocyclic Chem., (2011).