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Ichiro Hayakawa

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Organization: University of Tsukuba
Department: Department of Chemistry, Graduate School of Pure and Applied Sciences
Title:
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
Co-reporter:Ichiro Hayakawa, Akiyuki Ikedo, Takumi Chinen, Takeo Usui, Hideo Kigoshi
Bioorganic & Medicinal Chemistry 2012 Volume 20(Issue 19) pp:5745-5756
Publication Date(Web):1 October 2012
DOI:10.1016/j.bmc.2012.08.005
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.
2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4,5-dimethoxyphenyl)-, (2E)-
2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4,5-dimethoxyphenyl)-, (2E)-
CAS:1609187-24-7
2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4,5-dimethoxyphenyl)-, (2E)-
Boronic acid, B-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-
Boronic acid, B-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-
CAS:1609187-23-6
Boronic acid, B-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-
2-Propen-1-one, 3-(dimethylamino)-1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-, (2E)-
2-Propen-1-one, 3-(dimethylamino)-1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-, (2E)-
CAS:1415914-34-9
2-Propen-1-one, 3-(dimethylamino)-1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-, (2E)-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-(2-propyn-1-yloxy)-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-(2-propyn-1-yloxy)-
CAS:1252801-66-3
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-(2-propyn-1-yloxy)-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-7-hydroxy-6-methoxy-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-7-hydroxy-6-methoxy-
CAS:1252801-64-1
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-7-hydroxy-6-methoxy-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
CAS:1252801-62-9
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
4H-1-Benzopyran-4-one, 3-iodo-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
4H-1-Benzopyran-4-one, 3-iodo-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
CAS:1252801-61-8
4H-1-Benzopyran-4-one, 3-iodo-6-methoxy-7-[(tetrahydro-2H-pyran-2-yl)oxy]-
Ethanone, 1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
Ethanone, 1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
CAS:1252801-60-7
Ethanone, 1-[2-hydroxy-5-methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6,7-dimethoxy-
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6,7-dimethoxy-
CAS:1000593-01-0
4H-1-Benzopyran-4-one, 3-(4,7-dimethoxy-1,3-benzodioxol-5-yl)-6,7-dimethoxy-
3-IODO-6,7-DIMETHOXY-4H-CHROMEN-4-ONE
3-IODO-6,7-DIMETHOXY-4H-CHROMEN-4-ONE
CAS:1000377-17-2
3-IODO-6,7-DIMETHOXY-4H-CHROMEN-4-ONE