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Alan Kennan

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Name: Kennan, Alan
Organization: Colorado State University , USA
Department:
Title: Associate(PhD)
GLUE That Sticks to HIV: A Helix-Grafted GLUE Protein That Selectively Binds the HIV gp41 N-Terminal Helical Region
Co-reporter:Susanne N. Walker;Rachel L. Tennyson;Alex M. Chapman; Alan J. Kennan; Brian R. McNaughton
ChemBioChem 2015 Volume 16( Issue 2) pp:219-222
Publication Date(Web):
DOI:10.1002/cbic.201402531

Abstract

Methods for the stabilization of well-defined helical peptide drugs and basic research tools have received considerable attention in the last decade. Here, we report the stable and functional display of an HIV gp41 C-peptide helix mimic on a GRAM-Like Ubiquitin-binding in EAP45 (GLUE) protein. C-peptide helix-grafted GLUE selectively binds a mimic of the N-terminal helical region of gp41, a well-established HIV drug target, in a complex cellular environment. Additionally, the helix-grafted GLUE is folded in solution, stable in human serum, and soluble in aqueous solutions, and thus overcomes challenges faced by a multitude of peptide drugs, including those derived from HIV gp41 C-peptide.

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