Xiangdong Hu

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Name: 胡向东

Organization: Northwest University , China

Department: Department of Chemistry & Material Science

Title: NULL(PhD)

Chemicals
References

Nickel-catalyzed ring-opening of α-hydroxycyclobutenones with a remarkable ligand effect

Co-reporter:Songsong Gao

Chemical Communications 2017 vol. 53(Issue 76) pp:10540-10543

Publication Date(Web):2017/09/21

DOI:10.1039/C7CC03340K

A Ni-catalyzed ring-opening of α-hydroxycyclobutenones is reported herein. A remarkable ligand effect was observed during transformations following the ring-opening. The employment of PPh3 leads to the formation of 2-furanones 2 through a migration of an alkoxyl group, and 2-furanones 3 were generated through a migration of hydrogen in the presence of Xantphos, affording a divergent approach to 2-furanones bearing multiple functional groups.

Total Synthesis and Structural Reassignment of (±)-Cereoanhydride

Co-reporter:Zhiqiang Ren, Yu Hao, and Xiangdong Hu

Organic Letters 2016 Volume 18(Issue 19) pp:4958-4961

Publication Date(Web):September 19, 2016

DOI:10.1021/acs.orglett.6b02424

The first total synthesis of (±)-cereoanhydride has been achieved under the inspiration of its biosynthetic hypothesis. The tricyclic skeleton of trypethelone, the proposed biosynthetic precursor of cereoanhydride, was constructed by an interesting ring expansion of cyclobutenone in one step in which the introduced acetyl group is pivotal to avoid the following aerial oxidation. On the basis of X-ray crystallographic analysis, the structure of cereoanhydride is reassigned to a spiroketal structure 2, which should be formed through an isomerization of the originally proposed structure 1.

Four-Electron Electrocyclic Ring-Opening/Intermolecular [4+2]Cycloadditions of -Hydroxycyclobutenones: Stereoselective Synthesis of Multiple Substituted -Lactams

Co-reporter:Peidong Song;Qing Li;Congcong Wang;Wenfa Wu;Xu Mao;Jiajia Wang

Advanced Synthesis & Catalysis 2016 Volume 358( Issue 8) pp:1208-1212

Publication Date(Web):

DOI:10.1002/adsc.201501152

Intermolecular atom transfer radical addition of α,α,α-trichloromethyl ketones and alkenes mediated by a CuCl/bpy system

Co-reporter:Abulikemu Abudu Rexit, Xiangdong Hu

Tetrahedron 2015 Volume 71(Issue 15) pp:2313-2316

Publication Date(Web):15 April 2015

DOI:10.1016/j.tet.2015.01.021

An atom transfer radical addition reaction between a,a,a-trichloromethyl ketones and alkenes mediated by a CuCl/bpy system is reported, which presents a good example of intermolecular atom transfer radical addition reactions.An atom transfer radical addition reaction between α,α,α-trichloromethyl ketones and alkenes mediated by a CuCl/bpy system is reported, which presents a good example of intermolecular atom transfer radical addition reactions.

Total Synthesis of Carbazomycin G by a Thermal Ring Expansion/Self-Redox Reaction Cascade

Co-reporter:Yong An;Yunxia Wang

European Journal of Organic Chemistry 2014 Volume 2014( Issue 17) pp:3715-3718

Publication Date(Web):

DOI:10.1002/ejoc.201402065

Abstract

The total synthesis of carbazomycin G (7) has been accomplished in six steps and 26 % overall yield starting from commercially available materials. As an efficient access to the tricyclic skeleton of carbazomycins A–H, an interesting thermal ring expansion/self-redox reaction cascade of intermediate 11 has been developed in our study. The self-redox reaction of intermediate 10 can be readily accelerated in the presence of triethylamine, and a plausible reaction mechanism for this process has been proposed. Finally, the synthesis of carbazomycin G was completed by the widely applied regioselective methylation reaction.

Total Synthesis of Asterredione

Co-reporter:Sinan Gai, Qing Zhang, and Xiangdong Hu

The Journal of Organic Chemistry 2014 Volume 79(Issue 5) pp:2111-2114

Publication Date(Web):February 11, 2014

DOI:10.1021/jo4028177

The first total synthesis of asterredione was efficiently accomplished over five linear steps and in 21.5% overall yield. As the crucial step, the 2-quaternary 1,3-cyclopentenedione skeleton of asterredione was readily achieved using the Darzens/ring-expansion strategy developed in our laboratory. The structure of synthesized asterredione was fully confirmed by X-ray crystallography.

Protecting-Group-Free Synthesis of Taiwaniaquinone H Using a One-Pot Thermal Ring Expansion/4π-Electrocyclization Strategy

Co-reporter:Xiuxiang Yan and Xiangdong Hu

The Journal of Organic Chemistry 2014 Volume 79(Issue 11) pp:5282-5286

Publication Date(Web):May 16, 2014

DOI:10.1021/jo5008652

A strategy to the 6-5-6 tricyclic scaffold of taiwaniaquinoids was established on the basis of a one-pot thermal ring expansion/4π-electrocyclization process. The efficiency of this methodology has been demonstrated through its application in the total synthesis of taiwaniaquinone H, which has been accomplished in three steps and 14% overall yield in a protecting-group-free manner starting from commercially available materials.

Concise Synthesis of Linderaspirone A and Bi-linderone

Co-reporter:Fenfen Xiao;Wu Liu;Yunxia Wang;Qing Zhang;Xiang Li;Dr. Xiangdong Hu

Asian Journal of Organic Chemistry 2013 Volume 2( Issue 3) pp:216-219

Publication Date(Web):

DOI:10.1002/ajoc.201200184

An Alternative Approach to Direct Aldol Reaction Based on Gold-Catalyzed Methoxyl Transfer

Co-reporter:Moran Zhang;Yunxia Wang;Yang Yang

Advanced Synthesis & Catalysis 2012 Volume 354( Issue 6) pp:981-985

Publication Date(Web):

DOI:10.1002/adsc.201100789

Abstract

A mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold-catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.