On the basis of the principle of combination of active groups, a series of novel N-(4-([2,2′:5′,2′′-terthiophen]-5-yl)-2-methylbut-3-yn-2-yl) benzamide derivatives were designed, synthesized and systematically evaluated for their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than commercial Ningnanmycin. Especially, compound 8e with excellent anti-TMV activity (inactivation activity, 92.3%/500 µg·mL⁻¹; curative activity, 85.7%/500 µg·mL⁻¹ and protection activity, 64.7%/500 µg·mL⁻¹) emerged as a potential inhibitor of plant virus TMV. Quantitative structure-activity relationship studies proved that the van der Waals volume (V) and electronic parameter (∑(∑σ_o+σ_p) and ∑σ_m) for the substituent R¹ were very important for antiviral activities in this class of compounds.

A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Their structures were identified by ¹H NMR and elemental analyses. Preliminary bioassays indicated that some title compounds provided >80% control of Sclerotinia sclerotiorum at 50 µg/mL and >70% herbicidal activities against B. campestris at 100 µg/mL. Their structure-activities relationships were also discussed.

A variety of novel 3-(α-hydroxymethylene)pyrrolidine-2,4-dione derivatives containing a cyclopropane moiety were designed and synthesized in satisfactory yields. Their structures were confirmed by ¹H NMR and HRMS. The bioassays indicated that most of the title compounds displayed some extent herbicidal activities at 100 mg/mL.