Co-reporter:Yajun Yin;Can Wu;Junling Wang;Fengjuan Song;Wanqing Yue
Chemical Communications 2017 vol. 53(Issue 3) pp:529-532
Publication Date(Web):2017/01/03
DOI:10.1039/C6CC08502D
An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract. The DDS showed increased loading capacity, sustained drug release and better anticancer capability. Our research proved that a hydrogel DDS of other traditional Chinese medicines is possible.
Co-reporter:Can Wu, Ruixin Li, Yajun Yin, Junling Wang, Li Zhang, Wenying Zhong
Materials Science and Engineering: C 2017 Volume 76(Volume 76) pp:
Publication Date(Web):1 July 2017
DOI:10.1016/j.msec.2017.03.103
•A redox-responsive supramolecular hydrogel system was developed for delivering 10-hydroxy camptothecin (HCPT).•The hydrogel was formed by a biocompatible of cleaving disulfide bond.•The drug loading efficiency of the hydrogel was > 6.6 mg/mL.•The hydrogel possessed recovery and shear-shinning properties and could be used as injectable drug delivery system.•The hydrogel had a significantly sustained-release characteristic and possessed a favorable anticancer efficacy.A redox-responsive supramolecular hydrogel system was developed for delivering 10-hydroxy camptothecin (HCPT). The hydrogel was formed by cleaving disulfide bond. The combination of hydrophobic HCPT with hydrogel was a simple and effective way to improve the solubility of HCPT and the drug loading capacity of delivery system. The transmission electron microscopy (TEM) image revealed the self-assembled hydrogel was long and thin nanofibers with a width of < 10 nm. Rheological test verified the hydrogel had fine physical properties. In vitro release experiment showed that the accumulative releasing percentages within 72 h of HCPT-peptide hydrogels at 3.0%, 4.0%, 5.0% were 16.8%, 21.3%, and 26.8% respectively, which indicated the HCPT-peptide hydrogels had a significantly sustained-release characteristic. Besides, in vitro anticancer assay showed that HCPT-peptide hydrogels possessed a favorable anticancer efficacy. These results indicated that HCPT-peptide hydrogel had great potential for cancer treatment as a novel injectable drug delivery system.Download high-res image (181KB)Download full-size image
Co-reporter:Ran Wang, Hongjing Cui, Junling Wang, Nannan Li, Qian Zhao, Ying Zhou, Zhiyi Lv and Wenying Zhong
RSC Advances 2016 vol. 6(Issue 53) pp:47272-47280
Publication Date(Web):06 May 2016
DOI:10.1039/C6RA06667D
The present research reports a smart multifunctional oxidized single-wall carbon nanohorns (oxSWNHs) drug delivery system (DDS) which could enhance the anti-tumor effect of methotrexate (MTX). In this DDS (MTX@oxSWNHs–PEG–Tf), oxSWNHs loaded MTX was wrapped with DSPE–PEG–NH2 to prolong blood circulation half-life and target tumors with the help of covalent grafting of transferrin (Tf). The obtained DDS was characterized by scanning electron microscopy, UV-vis spectrophotometry, size distribution analysis and Z-potential measurement. Cell uptake studies on MAD-MB-231 and HepG2 cell lines confirmed that the MTX@oxSWNHs–PEG–Tf exerted higher antitumor activity compared with free drug or non-targeted counterpart. The in vivo antitumor efficacy of MTX@oxSWNHs–PEG–Tf was much stronger than that of the free drug group by comparing the change of tumor volume and weight. Toxicity studies showed little perceivable cardiotoxicity, hepatotoxicity and pulmonary toxicity of MTX@oxSWNHs–PEG–Tf, indicating that this new tumor-targeting DDS significantly enhanced the anti-tumor effect of MTX and decreased its side effects.
Co-reporter:Lili Pang, Hongjing Cui, Yu Liu, Wenying Zhong
Journal of Luminescence 2016 Volume 173() pp:274-278
Publication Date(Web):May 2016
DOI:10.1016/j.jlumin.2016.01.006
The dual-function anti-VEGF antibody conjugated CdHgTe quantum dots with good targeting property was successfully prepared. In this system, anti-VEGF antibody is not only a target agent but also a therapeutic drug. The anti-VEGF antibody conjugated near-infrared quantum dots can achieve the purposes of detection and treatment at the same time. As-prepared dual-function fluorescent probe in this work has been successfully applied for in vivo and in vitro imaging, which is promising in rapid tumor detection.
Co-reporter:Hongjing Cui;Ran Wang;Ying Zhou;Chang Shu;Fengjuan Song
Luminescence 2016 Volume 31( Issue 3) pp:813-820
Publication Date(Web):
DOI:10.1002/bio.3028
Abstract
To date, several fluorescent probes modified by a single targeting agent have been explored. However, studies on the preparation of dual-function quantum dot (QD) fluorescent probes with dual-targeting action and a therapeutic effect are rare. Here, a dual-targeting CdTe/CdS QD fluorescent probe with a bovine serum albumin–glycyrrhetinic acid conjugate and arginine-glycine-aspartic acid was successfully prepared that could induce the apoptosis of liver cancer cells and showed enhanced targeting in in vitro cell imaging. Therefore, the as-prepared fluorescent probe in this work is an efficient diagnostic tool for the simultaneous detection of liver cancer and breast cancer cells. Copyright © 2015 John Wiley & Sons, Ltd.
Co-reporter:Ying Zhou, Hongjing Cui, Chang Shu, Ya Ling, Ran Wang, Hongmei Li, Yadong Chen, Tao Lu and Wenying Zhong
Chemical Communications 2015 vol. 51(Issue 83) pp:15294-15296
Publication Date(Web):24 Aug 2015
DOI:10.1039/C5CC05503B
In this communication we report the first supramolecular hydrogel based on an antiepileptic drug carbamazepine (CBZ). CBZ plays the dual role of a drug molecule and an aromatic capping group in this self-delivery system.
Co-reporter:Ya Ling, Yuan Gao, Chang Shu, Ying Zhou, Wenying Zhong and Bing Xu
RSC Advances 2015 vol. 5(Issue 123) pp:101475-101479
Publication Date(Web):17 Nov 2015
DOI:10.1039/C5RA14156G
Doxorubicin (Dox) and Taxol can be covalently bonded to the same peptide segment via proper structural modification. Doxorubicin-maleimide derivative links to peptide via Michael addition reaction and Taxol-Succi-NHS active ester connects to the same peptide backbone through ester–amide exchange reaction. Enzymatic transformation, as an inherent biological process, is applied here to trigger the formation of nanofiber networks from the as prepared hydrogelator precursor. The precursor which loads equal molar ratio of Dox and Taxol can self-assemble to form a red stable hydrogel after dephosphorylation reaction catalyzed by alkaline phosphatase (ALP). This hydrogel could maintain sustained release of drugs and show strong anticancer effect. This work, as a new strategy to build a co-delivery system of covalently linked Dox and Taxol, owns the potential to serve as an injectable hydrogel for therapeutic applications.
Co-reporter:Ruixin Li;Chang Shu;Wei Wang;Xiaoliang Wang;Hui Li;Danke Xu
Journal of Pharmaceutical Sciences 2015 Volume 104( Issue 7) pp:2266-2275
Publication Date(Web):
DOI:10.1002/jps.24481
10-Hydroxy camptothecin (HCPT) has been proven to be a cell cycle-specific chemotherapeutic agent, which is a necessary choice to inhibit tumor residue growth and prevent tumor metastasis after surgery. But it suffers from light decomposition, poor solubility, relatively low bioavailability, and some side effects, which are the major obstacles toward its clinical use. Integration of hydrophobic HCPT with hydrophilic hydrogel is a facile approach to change the disadvantageous situation of HCPT. In this study, a novel supramolecular hydrogelator with improved synthetic strategy was triggered by chemical hydrolysis, and then self-assembled to hydrogel. Taking advantage of the high-equilibrium solubility of HCPT in hydrogelator solution, this hydrogel was utilized to load HCPT via encapsulation as an effective carrier. HCPT hydrogels were characterized by several techniques including transmission electronic microscopy, rheology, and UV spectroscopy. In vitro release experiment indicated HCPT hydrogel could maintain long term and sustained release of HCPT at high accumulated rate. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay showed that HCPT hydrogel had an optimized anticancer efficacy. Besides, with prominent physical properties of carrier, HCPT hydrogel possessed satisfactory stability, syringeability, and recoverability, demonstrating itself as a potential localized injectable drug delivery system. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2266–2275, 2015
Co-reporter:Junling Wang;Xiaona Ma;Chang Shu;Nannan Li
Journal of Nanoparticle Research 2015 Volume 17( Issue 9) pp:
Publication Date(Web):2015 September
DOI:10.1007/s11051-015-3184-1
Pharmacokinetic and biodistribution studies of doxorubicin-loaded carbon nanohorns (DOX@oxSWCNHs/SA) in plasma and tissues were carried out. A high-performance liquid chromatographic method was developed and validated to determine the amount of doxorubicin. Compared with free DOX, the half-life (t1/2) of DOX@oxSWCNHs/SA was increased from 5.44 ± 1.09 to 7.38 ± 0.98 h, area under plasma concentration–time curve (AUC0–∞) was increased from 0.63 ± 0.008 to 1.42 ± 0.12 μg/(ml h), and the clearance of DOX was declined from 634 ± 10.05 to 280 ± 24.06 ml/h. No DOX was detected in heart after intravenous injection with DOX@oxSWCNHs/SA, while higher concentrations of drug were found in other tissues. These results suggested that DOX@oxSWCNHs/SA had the potential to obtain a long retention time in blood, sustained drug release, and a low toxicity, especially low cardiotoxicity.
Co-reporter:Chang Shu, Ruixin Li, Yajun Yin, Deyan Yin, Yueqing Gu, Li Ding and Wenying Zhong
Chemical Communications 2014 vol. 50(Issue 97) pp:15423-15426
Publication Date(Web):14 Oct 2014
DOI:10.1039/C4CC05614K
A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg–Gly–Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.
Co-reporter:Xiaona Ma;Chang Shu;Jing Guo;Lili Pang;Lin Su
Journal of Nanoparticle Research 2014 Volume 16( Issue 7) pp:
Publication Date(Web):2014 July
DOI:10.1007/s11051-014-2497-9
A new targeted drug delivery system (DDS) based on oxidized single-wall carbon nanohorns (oxSWCNHs) was developed. Sodium alginate (SA) was used to modify oxSWCNHs to improve its dispersibility and biocompatibility, the first time such a modification to oxSWCNHs was reported. The humanized anti-vascular endothelial growth factor (anti-VEGF) monoclonal antibody was bound to the SA as targeting group to selectively kill the tumor cells. Doxorubicin hydrochloride (DOX) was conjugated to oxSWCNHs in basic pH solution by π–π stacking, and its release was triggered by the lower pH as the micro-environment of the tumor. Quantitative analyses showed that the DOX@oxSWCNHs/SA complexes contained 1 g DOX per gram of oxSWCNHs. Cell experiment showed that the DOX@oxSWCNHs/SA-mAb effectively targeted the human breast adenocarcinoma (MCF-7) cells and rarely adhered to the human embryonic kidney 293 (HEK293) cells. And the anticancer effects of the complexes were higher than those of the free DOX. Pharmaceutical efficiency in vivo showed that the relative tumor volumes (RTV) of normal saline (NS) group, oxSWCNH/SA-mAb (2.5 mg/kg) group, DOX (2.5 mg/kg) group, and DOX@oxSWCNHs/SA-mAb (2.5 mg/kg) group were approximately 61, 56, 14, and 7.2, respectively. In addition, higher drug dose (5 mg/kg) of DOX@oxSWCNHs/SA-mAb resulted in a better antitumor activity. Histopathological studies in mice confirmed that the DOX@oxSWCNHs/SA-mAb complexes did not demonstrate any detectable hepatotoxicity, cardiotoxicity, and nephrotoxicity.
Co-reporter:Chang Shu, Li Ding, Wenying Zhong
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014 Volume 131() pp:195-202
Publication Date(Web):15 October 2014
DOI:10.1016/j.saa.2014.04.029
•The interaction between ZnSe ZnS QDs and BSA was systematically investigated.•ZnSe ZnS QDs could enhance the binding affinity of some drugs for BSA based on FRET.•The double-logarithm strategy detecting the binding affinities of drugs to BSA was proposed.•Drugs quenched the fluorescence intensity of BSA or QDs effectively relate to polar groups of drugs.•The mechanism will be available on whether or not the nanoparticles affect drug transport.In the current work, using ZnSe ZnS quantum dots (QDs) as representative nanoparticles, the affinities of seven anticancer drugs for bovine serum albumin (BSA) were studied using fluorescence resonance energy transfer (FRET). The FRET efficiency of BSA–QD conjugates can reach as high as 24.87% by electrostatic interaction. The higher binding constant (3.63 × 107 L mol−1) and number of binding sites (1.75) between ZnSe ZnS QDs and BSA demonstrated that the QDs could easily associate to plasma proteins and enhance the transport efficacy of drugs. The magnitude of binding constants (103–106 L mol−1), in the presence of QDs, was between drugs–BSA and drugs–QDs in agreement with common affinities of drugs for serum albumins (104–106 L mol−1) in vivo. ZnSe ZnS QDs significantly increased the affinities for BSA of Vorinostat (SAHA), Docetaxel (DOC), Carmustine (BCNU), Doxorubicin (Dox) and 10-Hydroxycamptothecin (HCPT). However, they slightly reduced the affinities of Vincristine (VCR) and Methotrexate (MTX) for BSA. The recent work will not only provide useful information for appropriately understanding the binding affinity and binding mechanism at the molecular level, but also illustrate the ZnSe ZnS QDs are perfect candidates for nanoscal drug delivery system (DDS).The schematic representation of ZnSe ZnS QDs for influence of binding affinities of anticancer drugs to BSA based on FRET theory. Here, ZnSe ZnS QDs could enhance the affinity of SAHA, DOC, BUCN, DOX and HCPT for BSA, but showed competitive effect of MTX and VCR for BSA. So the interaction between nanoparticles and drugs will be available on whether or not the nanoparticles affect drug transport in blood.
Co-reporter:Lili Pang;Jian Xu;Chang Shu;Jin Guo;Xiaona Ma;Yu Liu
Luminescence 2014 Volume 29( Issue 8) pp:1177-1182
Publication Date(Web):
DOI:10.1002/bio.2679
ABSTRACT
High luminescence quantum yield water-soluble CdTe/ZnS core/shell quantum dots (QDs) stabilized with thioglycolic acid were synthesized. QDs were chemically coupled to fully humanized antivascular endothelial growth factor165 monoclonal antibodies to produce fluorescent probes. These probes can be used to assay the biological affinity of the antibody. The properties of QDs conjugated to an antibody were characterized by ultraviolet and visible spectrophotometry, fluorescent spectrophotometry, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, transmission electron microscopy and fluorescence microscopy. Cell-targeted imaging was performed in human breast cancer cell lines. The cytotoxicity of bare QDs and fluorescent probes was evaluated in the MCF-7 cells with an MTT viability assay. The results proved that CdTe/ZnS QD–monoclonal antibody nanoprobes had been successfully prepared with excellent spectral properties in target detections. Surface modification by ZnS shell could mitigate the cytotoxicity of cadmium-based QDs. The therapeutic effects of antivascular endothelial growth factor antibodies towards cultured human cancer cells were confirmed by MTT assay. Copyright © 2014 John Wiley & Sons, Ltd.
Co-reporter:Chang Shu, Bin Huang, Xiangdong Chen, Yan Wang, Xuequan Li, Li Ding, Wenying Zhong
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013 Volume 104() pp:143-149
Publication Date(Web):March 2013
DOI:10.1016/j.saa.2012.11.083
Strong fluorescence and low cytotoxicity ZnSe/ZnS quantum dots (QDs) were synthesized by a facile aqueous phase route. It overcame the defects such as instability and low quantum yield of the quantum dots synthesized by early aqueous phase route. l-Glutathione (GSH) and 3-mercaptopropaonic acid (MPA) were used as mixture stabilizers to synthesize high quality ZnSe/ZnS QDs. The samples were characterized by X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectrometry (XPS) and their optical properties were investigated by using UV–vis spectrophotometer, fluorescence spectrophotometer (FL), IR spectrophotometer and confocal laser scanning microscope. The synthesized ZnSe/ZnS QDs illuminated blue fluorescence under ultraviolet lamp. Its water-soluble property is excellent and the fluorescence intensity of ZnSe/ZnS QDs almost did not change after 4 months at room temperature. The average diameter of ZnSe/ZnS nanocrystals is about 3 nm and quantum yield (QY) could reach to 70.6% after repeat determination. Low cytotoxicity was ensured by investigated SCG7901 and RAW264.7 cells. In comparison with cadmium based nanocrystals, ZnSe/ZnS QDs posed low cytotoxicity. The cells viability remained 96.7% when the QDs concentration was increased to 10 μmol/L. The results in vitro indicate that ZnSe/ZnS QDs-based probes have good stability, low toxicity and biocompatibility for fluorescence imaging in cancer model system.Graphical abstractA facile “green” synthesis of water soluble ZnSe/ZnS quantum dots for cell imaging.Highlights► The synthetic method of QDs was facile, environmentally friendly and inexpensive. ► l-GSH and MPA as the mixture stabilizers of ZnSe/ZnS QDs. ► ZnSe/ZnS QDs with diameter of about 3 nm and quantum yield reached to 70.6%. ► Low cytotoxicity of QDs was ensured by investigated SCG7901 and RAW264.7 cells. ► MTT assay showed an increase in growth and division of RAW264.7cells with QDs.
Co-reporter:Wenying Zhong;Cui Zhang;Qin Gao;Hui Li
Microchimica Acta 2012 Volume 176( Issue 1-2) pp:101-107
Publication Date(Web):2012 January
DOI:10.1007/s00604-011-0695-z
Multicolor and water-soluble CdTe quantum dots (QDs) were synthesized with thioglycolic acid (TGA) as stabilizer. These QDs have a good size distribution, display high fluorescence quantum yield, and can be applied to the ultrasensitive detection of Pb(II) ion by virtue of their quenching effect. The size of the QDs exerts a strong effect on sensitivity, and quenching of luminescence is most effective for the smallest particles. The quenching mechanism is discussed. Fairly selective detection was accomplished by utilizing QDs with a diameter of 1.6 nm which resulted in a detection limit of 4.7 nmol L−1 concentration of Pb(II). The method was successfully applied to the determination of Pb(II) in spinach and citrus leaves, and the results are in good agreement with those obtained with atomic absorption spectrometry.
Co-reporter:Wenying Zhong, Jiaran Liang, Junsheng Yu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2009 Volume 74(Issue 3) pp:603-606
Publication Date(Web):15 October 2009
DOI:10.1016/j.saa.2009.06.059
Five sizes of water-dispersed CdTe quantum dots (QDs) stabilized by thioglycolic acid (TGA) with a high photoluminescence (PL) quantum yield were synthesized and a size dependent quenching of the fluorescence by cobalt ions was also observed. No matter for smaller or larger particles, obvious quenching effect was observed, and the fluorescence quenching of CdTe nanoparticles depended on the concentration of cobalt ions solution. However, CdTe QDs with different size showed dramatically different quenching efficiency, sensitivity, linear range and selectivity. With the increase of size, the quenching efficiency reduced correspondingly. The smallest particle was the most sensitive with the limit of detection for cobalt ions is 7.3 × 10−9 mol L−1 Co2+. For larger particles, the sensitivity was much lower, but the linear range was relatively wide, under optimal conditions, the quenched fluorescence intensity increased linearly with the concentration of cobalt ions ranging from 3.32 × 10−8 to 3.62 × 10−6 mol L−1. Besides, the influence on the fluorescence signal of foreign cations, including Ca2+, Mg2+, Ni2+, Ba2+, Zn2+, Cu2+, Fe3+ and Ag+ were also studied, results showed a high selectivity of the smaller QDs towards cobalt ions. According to Stern–Volmer-type equation, quenching of quantum dot luminescence was most effective for the smallest particles with the highest Ksv.
Co-reporter:Xia Ling, Wenying Zhong, Qi Huang, Kunyi Ni
Journal of Photochemistry and Photobiology B: Biology 2008 Volume 93(Issue 3) pp:172-176
Publication Date(Web):11 December 2008
DOI:10.1016/j.jphotobiol.2008.07.008
Fluorescence spectra, absorption spectra, DNA viscosity titrations, competition experiment, and iodide quenching experiment were used to study the interaction of DNA with pazufloxacin. DNA quenches the fluorescence of pazufloxacin significantly. No red shift and isobestic points are observed in UV titration experiment. DNA viscosity and iodide quenching results suggest that pazufloxacin does not intercalate into DNA. SsDNA has a stronger quenching effect on pazufloxacin than dsDNA has. Pazufloxacin interacts with DNA in a different mode from ethidium bromide, which is a typical intercalator of DNA. All these results indicate that pazufloxacin interacts with calf thymus DNA in the mode of groove binding. The quenching constant and thermodynamic constants have also been determined.
Co-reporter:Ruixin Li, Chang Shu, Wei Wang, Xiaoliang Wang, ... Wenying Zhong
Journal of Pharmaceutical Sciences (July 2015) Volume 104(Issue 7) pp:2266-2275
Publication Date(Web):1 July 2015
DOI:10.1002/jps.24481
10-Hydroxy camptothecin (HCPT) has been proven to be a cell cycle-specific chemotherapeutic agent, which is a necessary choice to inhibit tumor residue growth and prevent tumor metastasis after surgery. But it suffers from light decomposition, poor solubility, relatively low bioavailability, and some side effects, which are the major obstacles toward its clinical use. Integration of hydrophobic HCPT with hydrophilic hydrogel is a facile approach to change the disadvantageous situation of HCPT. In this study, a novel supramolecular hydrogelator with improved synthetic strategy was triggered by chemical hydrolysis, and then self-assembled to hydrogel. Taking advantage of the high-equilibrium solubility of HCPT in hydrogelator solution, this hydrogel was utilized to load HCPT via encapsulation as an effective carrier. HCPT hydrogels were characterized by several techniques including transmission electronic microscopy, rheology, and UV spectroscopy. In vitro release experiment indicated HCPT hydrogel could maintain long term and sustained release of HCPT at high accumulated rate. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay showed that HCPT hydrogel had an optimized anticancer efficacy. Besides, with prominent physical properties of carrier, HCPT hydrogel possessed satisfactory stability, syringeability, and recoverability, demonstrating itself as a potential localized injectable drug delivery system. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2266–2275, 2015
Co-reporter:Junling Wang, Ran Wang, Fangrong Zhang, Yajun Yin, Leixia Mei, Fengjuan Song, Mingtao Tao, Wanqing Yue and Wenying Zhong
Journal of Materials Chemistry A 2016 - vol. 4(Issue 36) pp:NaN6051-6051
Publication Date(Web):2016/08/16
DOI:10.1039/C6TB01469K
Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@oxCNHs/PEG-PA) showed high drug loading efficiency, enhanced drug release under laser irradiation, improved cellular uptake and increased therapeutic effect both in vitro and in vivo. In addition, NIR laser irradiation had a synergistic effect on overcoming MDR. The MDR-overcoming mechanism could be the efficient cellular uptake, enhanced drug release and reduced drug efflux by P-gp. These results demonstrated that ETO@oxCNHs/PEG-PA could be a promising drug delivery system for cancer MDR reversion.
Co-reporter:Chang Shu, Ruixin Li, Yajun Yin, Deyan Yin, Yueqing Gu, Li Ding and Wenying Zhong
Chemical Communications 2014 - vol. 50(Issue 97) pp:NaN15426-15426
Publication Date(Web):2014/10/14
DOI:10.1039/C4CC05614K
A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg–Gly–Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.
Co-reporter:Ying Zhou, Hongjing Cui, Chang Shu, Ya Ling, Ran Wang, Hongmei Li, Yadong Chen, Tao Lu and Wenying Zhong
Chemical Communications 2015 - vol. 51(Issue 83) pp:NaN15296-15296
Publication Date(Web):2015/08/24
DOI:10.1039/C5CC05503B
In this communication we report the first supramolecular hydrogel based on an antiepileptic drug carbamazepine (CBZ). CBZ plays the dual role of a drug molecule and an aromatic capping group in this self-delivery system.
Co-reporter:Yajun Yin, Can Wu, Junling Wang, Fengjuan Song, Wanqing Yue and Wenying Zhong
Chemical Communications 2017 - vol. 53(Issue 3) pp:NaN532-532
Publication Date(Web):2016/11/30
DOI:10.1039/C6CC08502D
An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract. The DDS showed increased loading capacity, sustained drug release and better anticancer capability. Our research proved that a hydrogel DDS of other traditional Chinese medicines is possible.