Lei Ma

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Name: 马磊; Ma, Lei

Organization: East China University of Science and Technology , China

Department: School of Pharmacy

Title: (PhD)

Chemicals
References

Steroidal glycosides from Marsdenia tenacissima

Co-reporter:Pham Van Khang, Ting Xu, Liuxin Xu, Nannan Zhou, Lihong Hu, Rui Wang, Lei Ma

Phytochemistry Letters 2015 Volume 12() pp:54-58

Publication Date(Web):June 2015

DOI:10.1016/j.phytol.2015.01.018

•Three new steroidal glycosides were isolated from Marsdenia tenacissima.•All compounds were prepared and evaluated inhibitory activity against nitric oxide in RAW276.4 macrophages.•They exhibited weak inhibitory effects against nitric oxide (NO) at concentration 1 μM.Three new compounds 1–3 as C21 steroidal glycosides of diester derivatives of tenacigenin B were isolated from the ethanolic extract of stems of Marsdenia tenacissima. All compounds were prepared and evaluated inhibitory activity of nitric oxide in RAW276.4 macrophages. Compounds 1–3 exhibited inhibitory effects against nitric oxide (NO).

A one-pot synthesis of isoindolin-1-imine derivatives

Co-reporter:Khangvan Pham, Zhongguo Zhang, Sida Shen, Lei Ma, Lihong Hu

Tetrahedron 2013 69(51) pp: 10933-10939

Publication Date(Web):

DOI:10.1016/j.tet.2013.10.076

A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate

Co-reporter:Min Lei, Lei Ma, Lihong Hu

Tetrahedron Letters 2011 Volume 52(Issue 20) pp:2597-2600

Publication Date(Web):18 May 2011

DOI:10.1016/j.tetlet.2011.03.061

A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives has been developed by one-pot condensation of 4-hydroxyquinolin-2(1H)-one, aldehyde, and malononitrile in the presence of ammonium acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reaction time, and little environmental impact.

A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst

Co-reporter:Min Lei, Lei Ma, Lihong Hu

Tetrahedron Letters 2010 Volume 51(Issue 32) pp:4186-4188

Publication Date(Web):11 August 2010

DOI:10.1016/j.tetlet.2010.06.005

Formamide derivatives have been synthesized in excellent yields from amine and formic acid in the presence of a catalytic amount of thiamine hydrochloride (VB1) at 80 °C. The advantages of this method are the use of a cheap, stable, non-toxic, and readily available catalyst, easy work-up, improved yields, and solvent-free conditions.

VB1–Al2O3-catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde, and amide

Co-reporter:Min Lei, Lei Ma, Lihong Hu

Tetrahedron Letters 2010 Volume 51(Issue 36) pp:4746-4749

Publication Date(Web):8 September 2010

DOI:10.1016/j.tetlet.2010.07.008

A novel and green approach for the efficient synthesis of β-amido ketones using VB1–Al2O3 as a heterogeneous catalyst for the first time from an aldehyde, enolizable ketones, and an amide in EtOH is described. The present methodology has several advantages from the economical and environmental points of view, such as simple procedure, low catalyst loading, high atom economy, and good yields.

An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction

Co-reporter:Min Lei;Lihong Hu

Monatshefte für Chemie - Chemical Monthly 2010 Volume 141( Issue 9) pp:1005-1008

Publication Date(Web):2010 September

DOI:10.1007/s00706-010-0357-6

A Biginelli-type three-component reaction involving cyclopentanone, aromatic aldehyde, and urea or thiourea for preparation of pyrimidinone derivatives under neat conditions is described. This condensation reaction can also take place smoothly in the presence of vitamin B1 in EtOH at 80 °C in good yield. The procedure is simple, high-yielding, time-saving, and environment friendly.

C21 Steroidal Glycosides from Cynanchum wilfordii

Co-reporter:Wen-Juan Xiang;Li-Hong Hu

Helvetica Chimica Acta 2009 Volume 92( Issue 12) pp:2659-2674

Publication Date(Web):

DOI:10.1002/hlca.200900057

Abstract

Eight new C₂₁ steroidal glycosides, named wilfosides A–H (1–8, resp.), along with one known compound wilfoside KIN (9), were isolated from the roots of Cynanchum wilfordii. The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D- and 2D-NMR, and ESI-MS techniques, as well as by comparison of the spectral data with those of related compounds.

Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols

Co-reporter:Min Lei, Lei Ma, Lihong Hu

Tetrahedron Letters 2009 50(46) pp: 6393-6397

Publication Date(Web):

DOI:10.1016/j.tetlet.2009.08.081

Six New C21 Steroidal Glycosides from Cynanchum bungeiDecne

Co-reporter:Hao Gan;Wen-Juan Xiang;Li-Hong Hu

Helvetica Chimica Acta 2008 Volume 91( Issue 12) pp:

Publication Date(Web):

DOI:10.1002/hlca.200890241

Abstract

Six new C₂₁ steroidal glycosides 1–6 were isolated from the stem parts of Cynanchum bungeiDecne. The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D- and 2D-NMR and HR-ESI-MS techniques as well as by comparison of their spectral data with those of related compounds.

Synthesis and SAR study of novel sarsasapogenin derivatives as potent neuroprotective agents and NO production inhibitors

Co-reporter:Hui Pan, Pham Van Khang, Dong Dong, Rui Wang, Lei Ma

Bioorganic & Medicinal Chemistry Letters (1 February 2017) Volume 27(Issue 3) pp:

Publication Date(Web):1 February 2017

DOI:10.1016/j.bmcl.2016.11.070

Sarsasapogenin, isolated from rhizomes of Anemarrhena asphodeloides, was found to be able to enhance memory. On the basis of the structure of Sarsasapogenin, a series of derivatives were synthesized and evaluated for their neuroprotective activity in PC12 cells and NO production inhibitory activity in RAW264.7 cell lines. The preliminary structure-activity relationship of them indicated that introduction of carbamate groups at the 3-hydroxyl position of sarsasapogenin might improve neuroprotective activity. Some synthesized derivatives such as AA3, AA4, AA9 and AA13 exhibited both notably neuroprotective activity and NO production inhibitory activity.