Chun Hu

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Name: 胡春
Organization: Shenyang Pharmaceutical University , China
Department:
Title: Professor(PhD)
Co-reporter:Jianshu Hu;Wei Zhu;Hu Meng;Ying Liu;Xin Wang
Chemical Biology & Drug Design 2014 Volume 84( Issue 6) pp:642-647
Publication Date(Web):
DOI:10.1111/cbdd.12356

A series of novel 1,4-dihydrothieno[3′,2′:5,6]thiopyrano[4,3-c]-pyrazole-3-carboxamide derivatives were synthesized and evaluated for their inhibitory activity to human 5-lipo-oxygenase (5-LOX). Compound 7c was found to exhibit significant inhibition to human 5-LOX with IC50 value of 5.7 ± 0.9 μm. Compound 7c was further studied using molecular docking in order to delineate its structure–activity relationship and to gain insight into the design of effective 5-LOX inhibitors.

4H-1-Benzopyran-4-one,2,3-dihydro-8-methyl-3-[[(4-nitrophenyl)amino]methyl]-
4H-1-Benzopyran-4-one,2,3-dihydro-3-[[(4-methoxyphenyl)amino]methyl]-8-methyl-
4H-1-Benzopyran-4-one,3-[[(4-chlorophenyl)amino]methyl]-2,3-dihydro-7-methyl-
4H-1-Benzopyran-4-one,2,3-dihydro-7-methyl-3-[[(4-methylphenyl)amino]methyl]-
4H-1-Benzopyran-4-one,2,3-dihydro-6-methyl-3-[[(4-nitrophenyl)amino]methyl]-
4H-1-Benzopyran-4-one,3-[[(4-chlorophenyl)amino]methyl]-2,3-dihydro-6-methyl-
4H-1-Benzopyran-4-one, 3-[[(4-chlorophenyl)amino]methyl]-2,3-dihydro-
4H-1-Benzopyran-4-one,2,3-dihydro-3-[[(4-methylphenyl)amino]methyl]-
1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-(2-phenylethyl)-3-thioxo-