Co-reporter:Jing Sun, Xinhua Peng, Hao Guo
Tetrahedron Letters 2015 Volume 56(Issue 6) pp:797-800
Publication Date(Web):4 February 2015
DOI:10.1016/j.tetlet.2014.12.086
We report herein a new and effective method for additive-free trifluoromethylation of aromatic aldehydes with TMSCF3. Normal acidic hydrolysis for desilylation in the workup process is not required in this transformation. This reaction presents a new environmentally friendly protocol to access trifluoromethylated benzyl alcohols.