A series of novel 2′,3′-diethanethio-2′,3′,5′-trideoxy-5′-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.

A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a–16c, showed significantly improved activity towards a broad range of tumor cell lines.A serires of novel 2′3′-dideoxy-2′,3′-diethanethioribonucleosides with triazole ring were prepared and their antitumour activity was evaluated.

The transformation of acetonides into acetates is frequently required in synthetic chemistry. An efficient procedure for direct conversion of acetonides into acetates in the presence of HClO4–SiO2 under mild conditions was developed. The acetonides of primary hydroxy groups are directly converted to diacetates, and the anomeric acetonides of furanosides are stereoselectively transformed into the corresponding acetyl β-d-furanosides with a 2-acetoxyisopropyl group.An efficient procedure for the direct conversion of acetonides into acetates in the presence of HClO4–SiO2 under mild conditions was developed. The primary hydroxyl acetonides are directly transprotected to diacetates, and anomeric acetonides of furanosides are stereoselectively transformed into corresponding acetyl β-d-furanosides with a 2-acetoxyisopropyl group.