Hong Wang

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Name: 王红; Wang, Hong

Organization: Zhejiang University of Technology , China

Department: College of Pharmaceutical Science

Title: Associate Professor(PhD)

Chemicals
References

Rhizoleucinoside, a Rhamnolipid–Amino Alcohol Hybrid from the Rhizobial Symbiont Bradyrhizobium sp. BTAi1

Co-reporter:Jianwei Chen, Jiadong Sun, Robert W. Deering, Nicholas DaSilva, Navindra P. Seeram, Hong Wang, and David C. Rowley

Organic Letters 2016 Volume 18(Issue 6) pp:1490-1493

Publication Date(Web):March 9, 2016

DOI:10.1021/acs.orglett.6b00461

Rhizoleucinoside (1), a unique rhamnolipid–amino alcohol hybrid, was isolated from the rhizobial symbiont bacterium Bradyrhizobium sp. BTAi1. Compound 1 features a rare rhamnolipid core attached to an unprecedented leucinol moiety. Its structure and absolute configuration were determined by spectroscopic analysis, tandem mass spectrometry, chemical degradation, and application of the Marfey’s method. Compound 1 possesses moderate cytotoxicity to BV-2 murine microglia and highly aggressive proliferating immortalized (HAPI) rat microglia cells.

Genetic regulation and manipulation for natural product discovery

Co-reporter:Jianwei Chen;Qihao Wu;Usama W. Hawas

Applied Microbiology and Biotechnology 2016 Volume 100( Issue 7) pp:2953-2965

Publication Date(Web):2016 April

DOI:10.1007/s00253-016-7357-3

Natural products are an important source of modern medical development, e.g., antibiotics, anticancers, immune modulators, etc. and will continue to be a powerful driving force for the discovery of novel potential drugs. In the heterologous hosts, natural products are biosynthesized using dedicated metabolic networks. By gene engineering, pathway reconstructing, and enzyme engineering, metabolic networks can be modified to synthesize novel compounds containing enhanced structural feature or produce a large quantity of known valuable bioactive compounds. The review introduces some important technical platforms and relevant examples of genetic regulation and manipulation to improve natural product titers or drive novel secondary metabolite discoveries.

Progress in Understanding the Genetic Information and Biosynthetic Pathways behind Amycolatopsis Antibiotics, with Implications for the Continued Discovery of Novel Drugs

Co-reporter:Su Chen;Qihao Wu;Qingqing Shen ;Dr. Hong Wang

ChemBioChem 2016 Volume 17( Issue 2) pp:119-128

Publication Date(Web):

DOI:10.1002/cbic.201500542

Abstract

Species of Amycolatopsis, well recognized as producers of both vancomycin and rifamycin, are also known for producing other secondary metabolites, with wide usage in medicine and agriculture. The molecular genetics of natural antibiotics produced by this genus have been well studied. Since the rise of antibiotic resistance, finding new drugs to fight infection has become an urgent priority. Progress in understanding the biosynthesis of metabolites greatly helps the rational manipulation of biosynthetic pathways, and thus to achieve the goal of generating novel natural antibiotics. The efforts made in exploiting Amycolatopsis genome sequences for the discovery of novel natural products and biosynthetic pathways are summarized.

A New Nortriterpene from the Root of Celastrus hypoleucus

Co-reporter:Hong Wang;Xuan Tian;GuoQing Ying

Helvetica Chimica Acta 2010 Volume 93( Issue 8) pp:1628-1633

Publication Date(Web):

DOI:10.1002/hlca.200900426

Abstract

A new nortriterpene, 2-hydroxy-3-methyl-21-oxo-12,24-dinor-D : B-friedooleana-1,3,5(10),7-tetraen-29-oic acid (1), was isolated from the root of Celastrus hypoleucus, together with the two known compounds, celastorol (2) and pristimerine (3). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1–3 exhibited in vitro significant antioxidant (against lipid peroxidation; by the TBARS method) and antitumor activities (against cancer cell lines P-388, A-549, HL-60, and BEL-7402).