Hiroshi Imagawa

Name:

Organization: Tokushima Bunri University

Department: Chemistry of Functional Molecule, Faculty of Pharmaceutical Sciences

Title:

Chemicals
References

Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

Co-reporter:Hiroshi Imagawa, Hayato Saijo, Hitomi Yamaguchi, Ken Maekawa, Takahiro Kurisaki, Hirofumi Yamamoto, Mugio Nishizawa, Masataka Oda, Michiko Kabura, Masahiro Nagahama, Jun Sakurai, Miwa Kubo, Megumi Nakai, Kosho Makino, Mitsuko Ogata, Hironobu Takahashi, Yoshiyasu Fukuyama

Bioorganic & Medicinal Chemistry Letters 2012 Volume 22(Issue 5) pp:2089-2093

Publication Date(Web):1 March 2012

DOI:10.1016/j.bmcl.2012.01.006

The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.

Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors

Co-reporter:Hiroshi Imagawa, Masataka Oda, Takayuki Takemoto, Rieko Yamauchi, Tomomi Yoshikawa, Hirofumi Yamamoto, Mugio Nishizawa, Hironobu Takahashi, Manabu Hashimoto, Kenta Yabiku, Masahiro Nagahama, Jun Sakurai

Bioorganic & Medicinal Chemistry Letters 2010 Volume 20(Issue 13) pp:3868-3871

Publication Date(Web):1 July 2010

DOI:10.1016/j.bmcl.2010.05.042

A novel sphingomyelin inhibitor RY221B-a, which contains a bipyridyl moiety as a metal coordination site was designed based upon the mechanism of phosphate ester hydrolysis. RY221B-a was synthesized from N-Boc-sphingosine in three steps via selective etherification using stannyl acetal. Synthesized RY221B-a exhibited relatively-strong inhibitory activity against Bc-SMase (IC50 = 1.2 μM).