Zuobing Xiao

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Organization: Shanghai Institute of Technology

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Chemicals
References

Development and application of nano-flavor-drug carriers in neurodegenerative diseases

Co-reporter:Wei-Hong Ji, Zuo-Bing Xiao, Gui-Ying Liu, Xin Zhang

Chinese Chemical Letters 2017 Volume 28, Issue 9(Volume 28, Issue 9) pp:

Publication Date(Web):1 September 2017

DOI:10.1016/j.cclet.2017.06.024

Neurodegenerative disease is one of the serious diseases of the human nervous system. There is no effective way to treat neurodegenerative diseases. Flavors such as curcumin, coumarin, have attracted increasing attention due to having a beneficial therapeutic effect on Alzheimer’s disease and Parkinson’s disease. But the use of most drugs is limited in clinical treatment because of blood-brain barrier. The use of nano-drug carriers such as liposomes, polymer micelles, polymer nanoparticles and magnetic nanoparticles, which can carry drugs across the blood-brain barrier, has brought hope for the treatment of neurodegenerative diseases.Download high-res image (257KB)Download full-size imageNano-drug carriers such as liposomes, polymer micelles, and polymer nanoparticles are used for neurodegenerative diseases, which can help drug pass the blood-brain barrier easily, and improve the therapeutic effect.

Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy

Co-reporter:Hongmei Liu, Ruilong Zhang, Yunwei Niu, Yan Li, Chenmeng Qiao, Jie Weng, Jun Li, Xiaoning Zhang, Zuobing Xiao and Xin Zhang

RSC Advances 2015 vol. 5(Issue 27) pp:20848-20857

Publication Date(Web):23 Jan 2015

DOI:10.1039/C4RA14875D

Hypoxia has a major role in tumor development and resistance to therapy. Therefore, the effective targeting and killing of hypoxic tumor cells is a key to successful tumor control. Here, we report the hypoxia-responsive prodrug micelles to deliver hydrophobic anticancer drug, which can selectively release the drugs to treat hypoxic tumor cells in a combined way. For this purpose, an azobenzene (AZO) bond, which imparts hypoxia sensitivity and specificity as cross linker, conjugated PEG–hexanethiol (PEG–C6) with combretastatin A-4 (CA4) to form PEG–C6–AZO–CA4 amphiphilic molecule. These PEG–C6–AZO–CA4 molecules self-assemble into micelles, which can encapsulate hydrophobic anticancer drug. The drug release behavior from PEG–C6–AZO–CA4 micelles was studied under normoxic or hypoxic conditions and the combinations of CA4 with hydrophobic drugs for tumor treatment in vitro were also investigated. As the first example of using AZO linkages to develop anticancer prodrug micelles as hydrophobic anticancer drugs delivery to kill the hypoxic tumor cells in a combination way, this study establishes PEG–C6–AZO–CA4 micelles as a promising drug delivery platform for hypoxic tumor therapy.

Adsorption capacity, kinetics, and thermodynamics of chitosan nanoparticles onto cotton fabrics without any chemical binders

Co-reporter:Mingxi Wang;Haiyan Fu;Yuanbin She;Guangyong Zhu;Jing Hu

Polymer Composites 2015 Volume 36( Issue 11) pp:2093-2102

Publication Date(Web):

DOI:10.1002/pc.23120

The stable adsorption of chitosan nanoparticles (CNs) onto cotton fabrics was successfully developed without any chemical binders. The adsorption kinetics, thermodynamics, and capacities under different experimental conditions were investigated. The structure and laundering durability of CNs-adsorbed cotton fabrics (CNs-cotton) were also characterized by Scanning Electron Microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), and Thermo Gravimetric Analysis (TGA). The adsorption capacities of cotton for CNs declined with the increasing CNs particle size and temperature. By contrast, adsorption capacities increased with the increasing adsorption pH and CNs mass concentration. The kinetic adsorption of CNs onto cotton fabrics was found to follow the pseudo-second-order kinetic model. The adsorption mechanism reflected a complex process, and the intra-particle diffusion was not the only rate-limiting step. The transfer and diffusion rates progressively increased with the decrease of adsorption temperature and CNs particle size. The negative values of the standard Gibbs free energy changes (ΔG°) and the standard enthalpy (ΔH°) indicated that the adsorption was exothermic and spontaneous at 5–75°C. The superior laundering resistance of CNs-cotton was demonstrated after 30 consecutive washes, thereby proving the stable adsorption of CNs onto cotton fabrics without chemical binders. POLYM. COMPOS., 36:2093–2102, 2015. © 2014 Society of Plastics Engineer

Sustained-release properties of cotton fabrics impregnated with nanotuberose fragrance

Co-reporter:Jing Hu;Meixia Chen;Jia Zhang

Journal of Applied Polymer Science 2015 Volume 132( Issue 12) pp:

Publication Date(Web):

DOI:10.1002/app.41678

ABSTRACT

Tuberose-fragrance (TF) loaded polybutylcyanoacrylate nanoparticles were successfully prepared via emulsion polymerization. The nanotuberose fragrance (Nano-TF) was directly impregnated into the cotton fabrics as an aromatic reagent. Dynamic light scattering and transmission electron microscopy showed that the average size of the spherical Nano-TF was 202.4 nm. Fourier transform infrared spectroscopy demonstrated that TF was encapsulated into the BCA nanoparticles and that the Nano-TF was in existence in the cotton fabrics. Thermogravimetric analysis showed that the loading TF content of the Nano-TF was 50.9% and that 10.02% Nano-TF had been impregnated into the fabrics. A lot of Nano-TF was adhered onto the surface of the cotton fabrics after 50 washings, as shown by scanning electron microscopy and gas chromatography/hydrogen flame ionization detection (GC–FID). In addition, GC–FID demonstrated that most aroma compounds of the cotton fabrics impregnated with Nano-TF only lost less than 20% of their aroma after 60 days of deposition and around 75% of their aroma after 6 h of deposition at 120°C, so they showed better sustained-release properties than those with TF. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41678.

Reducing sugars production from sugarcane bagasse wastes by hydrolysis in sub-critical water

Co-reporter:Guangyong Zhu;Xian Zhu

Clean Technologies and Environmental Policy 2013 Volume 15( Issue 1) pp:55-61

Publication Date(Web):2013 February

DOI:10.1007/s10098-012-0476-3

Biomass is an important renewable and sustainable source of energy. The rational utilization of biomass wastes is important not only for the prevention of environmental issues, but also for the effective utilization of natural resources. Reducing sugar, as a biomass energy precursor, can be further transformed to fuel alcohol in a fermentation process. Sub-critical water is an environmentally friendly solvent and attractive reaction medium. This study deals with the production of reducing sugar from sugarcane bagasse by hydrolysis in sub-critical water and the hydrolysis kinetics of sugarcane bagasse. Kinetics was conducted in a temperature range of 200–240°C using a 200-ml stainless steel batch reactor. A simplified kinetic model based on a parallel and consecutive reaction was proposed. The differential equations resulting from the model were fit to experimental data to obtain kinetic rate constants. The activation energy and the pre-exponential factor were determined. A good agreement between the simplified model and the experimental data was obtained. The experimental results show that the best hydrolysis technology involves a reaction temperature of 240°C, and a reaction time of 120 s. Under these conditions, the reducing sugar yield reaches 61.5%.

Study of cellulose pyrolysis using an in situ visualization technique and thermogravimetric analyzer

Co-reporter:Guangyong Zhu, Xian Zhu, Zuobing Xiao, Fengping Yi

Journal of Analytical and Applied Pyrolysis 2012 Volume 94() pp:126-130

Publication Date(Web):March 2012

DOI:10.1016/j.jaap.2011.11.016

A technique has been developed to study cellulose pyrolysis by in situ visualization of cellulose transformation in a quartz capillary under a microscope using a CCD camera monitoring system and Raman spectroscopy. The processes and temperature of cellulose transformation during pyrolysis reaction can be observed directly. In situ visualization of reaction revealed that how oil is generated and expulsed concurrently from cellulose during pyrolysis. The in situ visualization result is the first direct evidence to show cellulose pyrolysis transformation. Pyrolysis characteristics were investigated under a highly purified N2 atmosphere using a thermogravimetric analyzer from room temperature to 500 °C at the heating rate of 5 °C/min. The results showed that three stages appeared in this thermal degradation process. Kinetic parameters in terms of apparent activation energy and pre-exponential factor were determined.Highlights► An in situ visualization technique has been developed. ► The first direct evidence to show cellulose pyrolysis transformation. ► Pyrolysis characteristics of cellulose and kinetic parameters were obtained. ► Raman spectra of cellulose pyrolysis were studied.

Properties of osmanthus fragrance-loaded chitosansodium tripolyphosphate nanoparticles delivered through cotton fabrics

Co-reporter:Jing Hu;Zuo-bing Xiao;Shuang-shuang Ma;Ru-jun Zhou;Ming-xi Wang;Zhen Li

Journal of Applied Polymer Science 2012 Volume 123( Issue 6) pp:3748-3754

Publication Date(Web):

DOI:10.1002/app.34733

Abstract

Osmanthus fragrance-loaded chitosan nanoparticles (OF-NPs) were prepared via complex coacervation successfully. Then, the OF-NPs were applied in the cotton fabrics directly. The microstructures of OF-NPs were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transformation infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The sustained property of the cotton fabrics treated with OF-NPs was investigated with scanning electron microscopy (SEM) and gas chromatography-mass spectrometry (GC-MS). The common OF was also treated on fabrics for the parallel comparison. TEM and DLS displayed that the spherical OF-NPs kept about 130 nm and dispersed evenly. FTIR confirmed that OF had been interacted with chitosan via the hydrogen bonds. TGA demonstrated that the thermal stability of OF-NPs had been improved in contrast to OF and the loading content of OF was as high as 12.05%. SEM and GC-MS displayed that the cotton fabrics treated by OF-NPs had an excellent washing resistance. Overall, nanoencapsulation with CS-TPP will provide an excellent method for releasing fragrance. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

Properties of Aroma Sustained-release Cotton Fabric with Rose Fragrance Nanocapsule

Co-reporter:Jing HU, Zuobing XIAO, Rujun ZHOU, Shuangshuang MA, Mingxi WANG, Zhen LI

Chinese Journal of Chemical Engineering (June 2011) Volume 19(Issue 3) pp:523-528

Publication Date(Web):1 June 2011

DOI:10.1016/S1004-9541(11)60016-5

The aroma sustained-release cotton fabric was prepared by finishing rose fragrance nanocapsules directly on cotton. The structure and properties of nanocapsules were demonstrated by transmission electron microscope (TEM), dynamic light scattering (DLS), fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), gas chromatography-mass spectrometry (GC-MS) and electronic nose. The results showed that the spherical nanocapsule dispersed evenly and the average diameter kept 51.4 nm. The existence of COO peak (1741 cm−1) in the FTIR curve of the finished cotton fabric and the decrease of crystallinity demonstrated that rose fragrance nanocapsules have been incorporated into the cotton fabrics. The washing resistance of the cotton fabrics finished by 51.4 nm nanocapsules was much better than that by rose fragrance alone. Besides, the loss of fragrance from the cotton fabrics finished by 51.4 nm nanocapsules was obviously lower than that by 532 nm nanocapsules and rose fragrance. The smaller the nanocapsule size, the better the sustained release property. Electronic nose analysis also displayed that the aroma released from the cotton fabrics finished by nanocapsules after washing has no obvious variety in contrast to that without washing. The cotton fabrics finished by nanocapsules has the excellent sustained release property.

Ecological utilization of leather tannery waste with circular economy model

Co-reporter:Jing Hu, Zuobing Xiao, Rujun Zhou, Weijun Deng, Mingxi Wang, Shuangshuang Ma

Journal of Cleaner Production (January–February 2011) Volume 19(Issues 2–3) pp:221-228

Publication Date(Web):1 January 2011

DOI:10.1016/j.jclepro.2010.09.018

Circular economy (CE) focuses on resource-productivity and eco-efficiency improvement in a comprehensive way, especially on the industrial structure optimization of new technology development and application, equipment renewal and management renovation. The leather industry on the one side boosts the local economic development, on the other side however leads to the tremendous environment pollution and biological chains destruction. The CE model has been implemented as a new way of raw materials, water and energy consumption reduction in the leather industry. Reduce, Reuse, Recycle and Recover of the tannery effluents have been discussed in detail according to the different operation processes. The successful treatment approaches with analysis in the aspects such as wastewater, solid waste, sulfide, Chemical Oxygen Demand (COD), ammonium salt, chloride and chrome of the leather tannery with CE model provide guidance for the sustainable development of leather industry in the future.

Pyrolysis characteristics of bean dregs and in situ visualization of pyrolysis transformation

Co-reporter:Guangyong Zhu, Xian Zhu, Zuobing Xiao, Rujun Zhou, Fengping Yi

Waste Management (December 2012) Volume 32(Issue 12) pp:2287-2293

Publication Date(Web):1 December 2012

DOI:10.1016/j.wasman.2012.07.004

Biomass is an important renewable and sustainable source of energy. Waste products from biomass are considered as attractive feedstocks for the production of fuel. This work deals with the pyrolysis of bean dregs, a biomass waste from soybean processing industry. A technique has been developed to study bean dregs pyrolysis by in situ visualization of bean dregs transformation in a quartz capillary under a microscope using a charge-coupled device (CCD) camera monitoring system. The technique enables us to observe directly the processes and temperatures of bean dregs transformation during pyrolysis. In situ visualization of reaction revealed that how oily liquids are generated and expulsed concurrently from bean dregs during pyrolysis. Pyrolysis characteristics were investigated under a highly purified N2 atmosphere using a thermogravimetric analyzer from room temperature to 800 °C at different heating rates of 10, 30 and 50 °C/min. The results showed that three stages appeared in this thermal degradation process. The initial decomposition temperature and the peak shifted towards higher temperature with an increase in heating rate. Kinetic parameters in terms of apparent activation energy and pre-exponential factor were determined.Highlights► An in situ visualization technique has been developed. ► The first direct evidence to show bean dregs pyrolysis transformation. ► Pyrolysis characteristics of bean dregs were obtained.