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Masayuki Wasa

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Name: Wasa, Masayuki
Organization: Boston College , USA
Department: Department of Chemistry
Title: (PhD)

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Enantioselective Direct Mannich-Type Reactions Catalyzed by Frustrated Lewis Acid/Brønsted Base Complexes
Co-reporter:Ming Shang;Min Cao;Qifan Wang; Masayuki Wasa
Angewandte Chemie 2017 Volume 129(Issue 43) pp:13523-13526
Publication Date(Web):2017/10/16
DOI:10.1002/ange.201708103
AbstractAn enantioselective direct Mannich-type reaction catalyzed by a sterically frustrated Lewis acid/Brønsted base complex is disclosed. Cooperative functioning of the chiral Lewis acid and achiral Brønsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond-activated aldimines delivers β-aminocarbonyl compounds with high enantiomeric purity.
Frustrated Lewis Acid/Brønsted Base Catalysts for Direct Enantioselective α-Amination of Carbonyl Compounds
Co-reporter:Ming Shang, Xiaoxu Wang, Seung Moh Koo, Jennifer Youn, Jessica Z. Chan, Wenzhi Yao, Brian T. Hastings, and Masayuki Wasa
Journal of the American Chemical Society 2016 Volume 139(Issue 1) pp:95-98
Publication Date(Web):December 16, 2016
DOI:10.1021/jacs.6b11908
A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Brønsted base complex is disclosed. Cooperative functioning of the Lewis acid and Brønsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity.
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