Three series of novel 1,5-diphenyl-1-pentanone derivatives were designed and synthesized. Their structures were characterized by IR, ¹H NMR techniques, and elemental analysis. The insecticidal activities of the new compounds were preliminarily evaluated. The bioassay results indicated that the compounds X11–X30 displayed better aphicidal activity against Aphis gossypii than compounds X1–X10 and the lead compound (E)-1,5-diphenyl-1-penten-1-one (A). The inhibitory rates of compounds X6 and X29 were 100% against Plutella xylostella (L.) at 600 mg·L⁻¹. Compounds X12, X13, X19, X24, X25, X26 and X27 showed higher insecticidal activity against Tetranychus cinnabarinus (Boisduval) at 600 mg·L⁻¹ than the lead compound (A).

Diacylhydrazines have been found as molting hormone analogs since RH-5849 was reported as the first nonsteroidal ecdysone agonist in 1988. Optimizations on diacylhydrizines with benzoheterocycle containing oxygen were widely explored in recent years. In order to find novel compounds with high bioactivity, a series of mono- (I) and di-acylhydrazine (II) derivatives containing furan were designed and synthesized. Their structures were confirmed by ¹H NMR, IR, elemental analyses and single crystal X-ray diffraction analyses (II₇). The bioassay results showed that some of the mono-acylhydrazine (I) derivatives exhibited good larvicidal activity against Culex pipiens pallens at 10 mg/L and better than those of di-acylhydrazines (II). Generally, the anti-tumor activity of di-acylhydrazines (II) was better than that of mono-acylhydrazines (I).

42 novel diacylhydrazine derivatives containing furan were synthesized by the reaction of 5-substituted phenyl-2-furoyl chloride with substituted benzohydrazide in anhydrous dichloromethane under reflux. Their structures were confirmed by IR, ¹H NMR, MS and elemental analysis. Insecticidal and antitumor activity of these new compounds was evaluated. The preliminary bioassays showed that the target compounds exhibited larvicidal activity to the Mythimna separate, some of them exhibited good or moderate larvicidal activity. At the concentration of 0.1%, compounds I2, I4, I5, and III1 showed 95.0%, 90.0%, 95.0% and 95.0% larvicidal activity to Mythimna separate respectively. Some compounds such as I2, I4, I5 and III1 showed the typical IGRs' activity, which could induce the larvae premature, abnormal, and lethal larval molt. Results of anticancer activity indicated that some compounds exhibited potential activity against some human cancer cell lines, for example, I1 and IV showed good activity to the BGC-823 and the inhibitory rates were 60.86% and 61.94% respectively at 10 µmol/L.

A new β-CD derivative, heptakis [2,6-di-O-pentyl-3-O-(4′-chloro-5′-pyridylmethyl)]-β-CD, was synthesized by the selective introduction of a pyridyl group on the 3-positions of β-CD. The chromatographic properties of the pyridyl β-CD derivative were studied by using it as the stationary phase in capillary GC. The polarity of the prepared stationary phase was moderate, and the separation results demonstrated that the prepared stationary phase possessed excellent separation ability and chiral recognition for a wide range of analytes. Not only the aromatic positional isomers, such as o-, m-, p-xylene and α-, β-naphthol isomers, but also some compounds with multi-stereogenic centers, such as n-(1-methylpropyl)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxamide and n-(1-methylpropyl)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxamide with three stereogenic centers including eight configurational isomers, were successfully separated. The results also indicated that the polarity of the β-CD derivative, and the hydrogen bonding between the β-CD derivative, and the analytes had a very important effect on separation.