Co-reporter:Xian Fu, Hengxing Liang, Bing Xia, Chunyan Huang, Baocheng Ji, and Yan Zhou
Journal of Agricultural and Food Chemistry September 20, 2017 Volume 65(Issue 37) pp:8256-8256
Publication Date(Web):August 31, 2017
DOI:10.1021/acs.jafc.7b03803
A simple and rapid approach for the simultaneous detection of trace amounts of six sulfonamides in chicken muscle was developed using pulsed direct current electrospray ionization tandem mass spectrometry (pulsed-dc ESI-MS/MS). The pretreatment of chicken muscle samples consisted of two steps: acetonitrile extraction and n-hexane delipidation. Sulfonamides do not need to be derivatized or chromatographed prior to pulsed-dc ESI-MS/MS. The factors affecting the performance of pulsed-dc ESI-MS/MS were studied. Under optimum conditions, the quantitative performance of pulsed-dc ESI-MS/MS was validated according to European Union Decision 2002/657/EC, and the sensitivity of pulsed-dc ESI-MS/MS was 3 times higher than that of ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The limits of detection obtained by pulsed-dc ESI-MS/MS were in the range of 0.07–0.11 μg/kg. The proposed method was simple, rapid, and sensitive, and was successfully used for quantitation and rapid screening of sulfonamides in real chicken muscle samples.Keywords: chicken muscle; European Union Decision 2002/657/EC; pulsed-dc ESI-MS/MS; quantitation; rapid screening; sulfonamides; UPLC-MS/MS;
Co-reporter:Min Zhao, Zhuo-Ma Da-Wa, Yu-Cheng Gu, Da-Le Guo, ... Yan Zhou
Phytochemistry Letters 2017 Volume 20(Volume 20) pp:
Publication Date(Web):1 June 2017
DOI:10.1016/j.phytol.2017.04.037
•Three new chlorinated phenolic glycosides were isolated from Przewalskia tangutica.•Their structures were elucidated by NMR analysis and chemical methods.•Przewatangoside A showed weak cytotoxicity against SMMC-7721.Three new chlorinated phenolic glycosides, namely przewatangosides A-C (1-3), along with one known compound, globosumoside A (4), were isolated from the whole plants of Przewalskia tangutica. Their structures were unequivocally determined by extensive spectroscopic analysis and chemical method. The cytotoxic activities of the isolated phenolic glycosides (1-4) were evaluated against the five human cancer cell lines A549, MCF-7, SMMC-7721, HepG2 and HL-60. Przewatangoside A (1) exhibited weak cytotoxicity against SMMC-7721 with the IC50 value of 38.1 μM. All the tested compounds were inactive (IC50 > 50 μM) to the normal human hepatocyte cell line (L02).Download high-res image (306KB)Download full-size image
Co-reporter:Min Zhao, Da-Le Guo, Lv-Yi Yuan, Yu-Cheng Gu, ... Yan Zhou
Phytochemistry Letters 2017 Volume 19(Volume 19) pp:
Publication Date(Web):1 March 2017
DOI:10.1016/j.phytol.2016.11.010
•Three new labdane diterpenes were isolated from Loxocalyx urticifolius.•Their structures were elucidated by NMR analysis and chemical method.•The absolute configuration of 1 was confirmed by X-ray crystallographic analysis.•Compound 3 exhibited weak cytotoxicity against A549 and MCF-7.Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants of Loxocalyx urticifolius Hemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell lines A549, HepG2, HL-60 and MCF-7. 13-epiloxocalyxin E (3) exhibited selective cytotoxicity against A549 and MCF-7 with the IC50 values of 22.4 and 47.3 μM, respectively.Download high-res image (96KB)Download full-size image
Co-reporter:Baocheng Ji, Bing Xia, Yuanji Gao, Fengwei Ma, Lisheng Ding, and Yan Zhou
Analytical Chemistry 2016 Volume 88(Issue 10) pp:5072
Publication Date(Web):April 25, 2016
DOI:10.1021/acs.analchem.5b03990
In this study, we report a simple and economical ballpoint electrospray ionization mass spectrometry (BP-ESI-MS) technique. This combines a small ballpoint tip with a syringe pump for the direct loading and ionization of various samples in different phases (including solution, semisolid, and solid) and allows for additional applications in surface analysis. The tiny metal ball on the ballpoint tip exhibits a larger surface for ionization than that of a conventional sharp tip end, resulting in higher ionization efficiency and less sample consumption. The adamant properties of the ballpoint tip allow sampling by simply penetrating or scraping various surfaces, such as a fruit peel, paper, or fabric. Complex samples, such as fine herbal powders and small solid samples, could be stored in the hollow space in the ballpoint socket and subsequently extracted online, which greatly facilitated MS analysis with little to no sample preparation. Positive ion mode was attempted, and various compounds, including amino acids, carbohydrates, flavonoids, and alkaloids, were detected from different types of samples. The results demonstrated that the special and excellent physical characteristics of ballpoint tips allowed for fast and convenient sampling and ionization for mass spectrometry analysis by the BP-ESI-MS method.
Co-reporter:Baocheng Ji, Bing Xia, Jie Liu, Yuanji Gao, Lisheng Ding, Yan Zhou
Journal of Chromatography A 2016 Volume 1466() pp:199-204
Publication Date(Web):30 September 2016
DOI:10.1016/j.chroma.2016.09.014
•A fractionized sampling and stacking interface was developed for 2D LC system.•The interface was successfully applied in developing an online heart-cutting 2D LC.•Large volume injection in 2D was achieved using the interface.•Excellent peak compression efficiency was achieved in 2D.•A complex TCM sample was successfully analyzed using the developed method.In this study, an efficient interface, based on a fractionized sampling and stacking (FSS) strategy, was developed for online heart-cutting two-dimensional liquid chromatography (2D LC). This interface consisted of a two-position 4-port valve, a two-position 6-port valve and a two-position 10-port valve equipped with two 450-μL stainless steel loops. Hydrophilic interaction chromatography (HILIC) and reversed phase liquid chromatography (RP LC) were used in the first and second dimensions, respectively. The peak compression efficiency of this interface was investigated by analysis of ten standards. Good peak shapes of the ten standards were observed when the dilution ratio was over five and the co-eluate plug volume was less than 10 μL. The 2D LC system was further applied to analysis of a crude extract of Panax ginseng leaves. Seventeen major constituents in the extract were monitored, which could not be well separated by one-dimensional (1D) HILIC or RP LC method in a long separation gradient. The FSS interface successfully achieved the efficient combination of HILIC and RP LC, and the 17 constituents in ginseng extract got well separated under the optimized conditions. The FSS interface has shown great potential for 2D LC analysis of complex natural product samples.
Co-reporter:Feng-wei Ma, Si-yuan Kong, Hong-sheng Tan, Rong Wu, Bing Xia, Yan Zhou, Hong-xi Xu
Carbohydrate Polymers 2016 Volume 152() pp:699-709
Publication Date(Web):5 November 2016
DOI:10.1016/j.carbpol.2016.07.062
•A novel polysaccharide, PSP-2B, was isolated from aqueous extracts of Prunellae Spica.•PSP-2B was a sulfated polysaccharide with molecular weight approximately 32 kDa.•The framework of PSP-2B was speculated to be a branched arabinogalactomannan.•PSP-2B exhibited interesting activity against herpes simplex virus.In the present study, a novel polysaccharide, PSP-2B, was isolated from aqueous extracts of Prunellae Spica by direct ultrafiltration membrane separation and gel chromatography purification. PSP-2B is a partially sulphated polysaccharide with a molecular weight of approximately 32 kDa. Its sulfate content is 10.59% by elemental analysis. The major sugars comprising PSP-2B are arabinose, galactose and mannose, in addition to small amounts of glucose and uronic acids. The framework of PSP-2B is speculated to be a branched arabinogalactomannan, and the side chains are terminated primarily by the Araf residues. PSP-2B also contains 2.98% protein. PSP-2B exhibits activity against herpes simplex virus (HSV), with a half maximal inhibitory concentration (IC50) of approximately 69 μg/mL for HSV-1 and 49 μg/mL for HSV-2. However, PSP-2B demonstrated no cytotoxicity even when its concentration was increased to 1600 μg/mL, suggesting that it has potential as an anti-HSV drug candidate.
Co-reporter:Yuanji Gao, Bing Xia, Jie Liu, Lisheng Ding, Bangjing Li, Yan Zhou
Applied Surface Science 2015 Volume 329() pp:150-157
Publication Date(Web):28 February 2015
DOI:10.1016/j.apsusc.2014.12.150
Highlights
- •
We report a reversible solvent-induced transition from superhydrophobicity to hydrophilicity.
- •
We tuned reversibly the wettability based on the silver mesodendritic structure.
- •
The lipid-like bilayers are formed via non-covalent bond.
- •
Wettability switching on liquid/solid interfaces was achieved by tuning the surface chemical composition.
Co-reporter:Da-Le Guo, Min Zhao, Shi-Ji Xiao, Bing Xia, Bo Wan, Yu-Cheng Gu, Li-Sheng Ding, Yan Zhou
Phytochemistry Letters 2015 Volume 14() pp:260-264
Publication Date(Web):December 2015
DOI:10.1016/j.phytol.2015.10.024
•Two new diketopiperazine derivatives (1-2) were isolated from Alternaria alternata.•A new glucosyl sesterterpene (3) was isolated from Alternaria alternata.•All the compounds were assayed for antimicrobial activity.Two diketopiperazine derivatives, altenarizines A (1) and B (2), and a new glucosyl sesterterpene, 24-α-d-glucosyl-(−)-terpestacin (3), together with two known phytotoxic sesterterpenes, (−)-terpestacin (4) and fusaproliferin (5), were isolated from the fermentation broth of an endophytic fungus Alternaria alternata, which was obtained from the fresh root of Ceratostigma griffithii. Structures of all the isolates were identified by spectroscopic data.
Co-reporter:Bing Xia, Yan Zhou, Hong Sheng Tan, Li Sheng Ding, Hong Xi Xu
Food Chemistry 2014 Volume 152() pp:237-244
Publication Date(Web):1 June 2014
DOI:10.1016/j.foodchem.2013.11.151
•A UPLC–PDA–QTOF–MS method was applied to investigate triterpenoids in Poria cocos.•Seven triterpenoids were quantified in 40 batches of P. cocos.•Ten marker triterpenoids identified and 31 triterpenoids were characterized.•This method can be used for bitterness evaluation and quality control of P. cocos.A sensitive, precise and accurate method was developed to screen and quantify triterpenoids based on ultra-performance liquid chromatography–photodiode array–quadrupole time-of-flight mass spectrometry (UPLC–PDA–QTOF–MS). An exact neutral loss scan of 62.0004 Da (CH2O3) was used to selectively detect triterpenoids in Poria cocos, followed by a survey scan for exact masses of precursor and fragment ions of these triterpenoids. The developed method was applied to quantify seven major triterpenoids in 40 P. cocos samples of different origins within 18 min, and a total of 31 triterpenoids were unequivocally or tentatively identified. Principal component analysis of these samples showed a clear separation of three groups, and ten triterpenoids play key roles in differentiating these samples were obtained from the OPLS-DA variable influence on projection (VIP) plot and then unequivocally or tentatively identified. The developed method can be applied for rapid bitterness evaluation, quality control and authenticity establishment of P. cocos.
Co-reporter:Bing Xia, Mengmeng Feng, Gang Xu, Jindi Xu, Songlin Li, Xiaozhen Chen, Lisheng Ding, and Yan Zhou
Journal of Agricultural and Food Chemistry 2014 Volume 62(Issue 22) pp:4979-4987
Publication Date(Web):May 15, 2014
DOI:10.1021/jf5009204
Tobacco samples of a same cultivar grown in different plantations in China were evaluated for their chemical compositions at different maturities for the first time. This was accomplished by a comprehensive and reliable method using gas chromatography–mass spectrometry (GC–MS) and high performance liquid chromatography–photodiode array-quadrupole time-of-flight mass spectrometry (HPLC-PDA-QTOF-MS) to analyze the fat-soluble and polar components in 12 batches of tobacco samples of three origins and four maturities. The GC–MS analyses showed that tobacco samples harvested at 40 days after transplantation exhibited more fat-soluble components, while those harvested at 100 days after transplantation exhibited the least fat-soluble components. Tentatively, identification of the main components as well as quantitative analyses of eight reference compounds, including five alkaloids, two polyphenols, and a coumarin, was performed by the developed HPLC–QTOF-PDA method. Results showed significant differences among origins and maturities in the contents of these compounds. The nicotine contents showed great variety among the 12 tobacco samples. The highest nicotine content were found in a sample from Zhengzhou harvested at 40 days after transplantation (ZZ-T with 25399.39 ± 308.95 μg/g), and the lowest nicotine level was detected in a sample from Zunyi harvested at 60 days after transplantation (ZY-X with 1654.49 ± 34.52 μg/g). The highest level of rutin was found in a Jiangchuan sample harvested at 60 days after transplantation (JC-X with 725.93 ± 40.70 μg/g), and the lowest rutin content was detected in a Zunyi tobacco sample harvested at 60 days after transplantation (ZY-X with 87.42 ± 2.78 μg/g). The developed method provided a convenient approach which might be applied for rapid maturity evaluation and tobacco flavor identification and also holds the potential for analysis of compounds present in other plants.
Co-reporter:Shi-Ji Xiao, Fang Chen, Li-Sheng Ding, Yan Zhou
Chinese Chemical Letters 2014 Volume 25(Issue 3) pp:463-464
Publication Date(Web):March 2014
DOI:10.1016/j.cclet.2013.11.053
Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound 1 was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). Compound 1 was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.
Co-reporter:Shi-Ji Xiao, Xin-Xiang Lei, Bing Xia, Hong-Ping Xiao, Da-Hai He, Dong-Mei Fang, Hua-Yi Qi, Fang Chen, Li-Sheng Ding, Yan Zhou
Tetrahedron Letters 2014 Volume 55(Issue 17) pp:2869-2871
Publication Date(Web):23 April 2014
DOI:10.1016/j.tetlet.2014.03.091
Two novel norlignans, gymnothedelignans A and B were isolated from the whole plants of Gymnotheca chinensis. These norlignans possess a rare 2/5 epoxy benzocycloheptanone skeleton. Their structures were established on the basis of 1D and 2D NMR spectral data analysis, and the absolute stereochemistry of gymnothedelignans A and B was further confirmed by single crystal X-ray diffraction analysis.
Co-reporter:Shi-Ji Xiao, Xin-Xiang Lei, Bing Xia, Dan-Qing Xu, Hong-Ping Xiao, Hong-Xi Xu, Fang Chen, Li-Sheng Ding, Yan Zhou
Tetrahedron Letters 2014 Volume 55(Issue 43) pp:5949-5951
Publication Date(Web):22 October 2014
DOI:10.1016/j.tetlet.2014.09.044
Two novel lignans, gymnothespirolignans A (1) and B (2), possessing a rare polycyclic spiro skeleton, were isolated from the endemic plant of Gymnotheca involucrata Pei. Their structures were determined by spectroscopic evidences and the absolute configurations were confirmed by single crystal X-ray diffraction analysis. Compounds 1 and 2 showed promising antiviral activities against RSV with an IC50 value of 31.87 and 17.51 μM, respectively.
Co-reporter:Shiji Xiao;Dahai He;Dongmei Fang;Fang Chen;Lisheng Ding
Helvetica Chimica Acta 2014 Volume 97( Issue 4) pp:499-506
Publication Date(Web):
DOI:10.1002/hlca.201300208
Abstract
Four new biphenyl lignans, 1–4, with a tetrahydrofuran moiety were isolated from the MeOH extract of the whole plant of Gymnotheca chinensis. Their chemical structures were established by means of spectroscopic analysis, including 1D and 2D NMR spectroscopy and comparison with previously reported data. Compounds 1–4 occur as mixtures of atropisomers as revealed by variable-temperature NMR experiments.
Co-reporter:Shi-Ji Xiao, Yuan-Zhi Lao, Fang Chen, Hong-Xi Xu, Li-Sheng Ding, Yan Zhou
Phytochemistry Letters 2014 Volume 8() pp:38-40
Publication Date(Web):May 2014
DOI:10.1016/j.phytol.2014.01.007
•Two new lignans were isolated from Gymnotheca chinensis Decne.•Compound 1 exhibited moderate cytotoxicity against five human cancer cell lines.•Compound 2 exhibited weak cytotoxicity against the A549 cancer cell line.Two new lignans, gymnothelignans V (1) and W (2), were isolated from a methanol extraction of Gymnotheca chinensis Decne. Their structures were established on the basis of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited moderate cytotoxicity against the HCT116, HCT15, A549, MCF-7 and HepG2 cancer cell lines with IC50 values of 45.1 μM, 26.9 μM, 49.6 μM, 30.0 μM and 49.7 μM, respectively. Compound 2 exhibited weak cytotoxicity against the A549 cancer cell line with an IC50 value of 41.3 μM.
Co-reporter:Bing Xia;Mengmeng Feng;Lisheng Ding
Chromatographia 2014 Volume 77( Issue 11-12) pp:783-791
Publication Date(Web):2014 June
DOI:10.1007/s10337-014-2684-y
Supercritical fluid chromatography (SFC) is a powerful separation technique particularly in the area of enantioseparations. With rapid analysis speed, wide polarity compatibility, higher column efficiency and lower cost of the mobile phase, SFC is regarded as a better choice than high-performance liquid chromatography for drug discovery. In the development of separation method, the choice of modifier and/or additive is the key point of optimum separation. However, such screening of SFC is typically time-consuming. In this study, an autoblending protocol was introduced to speed up the modifier and/or additive screening process, which was performed on a separate programmable gradient proportioning system. The protocol prepares mobile phases on the fly to speed up the screening of modifiers and/or additives and reduces the waste of solutions. Furthermore, by switching mobile phase in the same run, separation of different types of compounds could also be achieved. This system was successfully applied to screen modifier–additive combinations of three alkaloids and three polyphenols by switching to two mobile phase conditions, as well as by a ternary additive mobile phase on an SFC system. The proposed protocol allows fast separation method development of SFC, which was proved to be rapid, simple, and reproducible.
Co-reporter:Jin-Rong Li;Min Li;Bing Xia;Li-Sheng Ding;Hong-Xi Xu
Journal of Separation Science 2013 Volume 36( Issue 13) pp:2114-2120
Publication Date(Web):
DOI:10.1002/jssc.201300289
An approach for rapid optimization of ultra-high-performance supercritical fluid chromatographic (UHPSFC) gradient by response surface methodology was developed for fast separation of complex crude extracts of the leaves of Rosa sericea. The optimization was performed with Box–Behnken designs and the multicriteria response variables were described using Derringer's desirability. Based on factorial design experiments, five factors were selected for Box–Behnken designs to optimize the UHPSFC conditions, which led to 46 experiments being performed within 8 h. An evaporative light-scattering detector (ELSD) was used, and quantitative analysis of main components in R. sericea samples was employed to evaluate the statistical significance of the parameters on UHPSFC-ELSD analytes response. The results indicated that the optimized UHPSFC-ELSD method is very sensitive with LODs and LOQs below 1.19 and 4.55 μg/mL, respectively. The overall intra- and interday variations were less than 3.91 and 6.41%, respectively. The recovery of the method ranged from 95.66 to 104.22%, with RSD < 5.91%. This newly developed UHPSFC-ELSD method was demonstrated to be fast and sensitive in analyzing complex herbal extracts of Traditional Chinese Medicines.
Co-reporter:Haifeng Wu, Jian Guo, Shilin Chen, Xin Liu, Yan Zhou, Xiaopo Zhang, Xudong Xu
Journal of Pharmaceutical and Biomedical Analysis 2013 Volume 72() pp:267-291
Publication Date(Web):18 January 2013
DOI:10.1016/j.jpba.2012.09.004
Over the past few years, the applications of liquid chromatography coupled with mass spectrometry (LC–MS) in natural product analysis have been dramatically growing because of the increasingly improved separation and detection capabilities of LC–MS instruments. In particular, novel high-resolution hybrid instruments linked to ultra-high-performance LC and the hyphenations of LC–MS with other separation or analytical techniques greatly aid unequivocal identification and highly sensitive quantification of natural products at trace concentrations in complex matrices. With the aim of providing an up-to-date overview of LC–MS applications on the analysis of plant-derived compounds, papers published within the latest years (2007–2012) involving qualitative and quantitative analysis of phytochemical constituents and their metabolites are summarized in the present review. After briefly describing the general characteristics of natural products analysis, the most remarkable features of LC–MS and sample preparation techniques, the present paper mainly focuses on screening and characterization of phenols (including flavonoids), alkaloids, terpenoids, steroids, coumarins, lignans, and miscellaneous compounds in respective herbs and biological samples, as well as traditional Chinese medicine (TCM) prescriptions using tandem mass spectrometer. Chemical fingerprinting analysis using LC–MS is also described. Meanwhile, instrumental peculiarities and methodological details are accentuated.
Co-reporter:Bing Xia;Xin Liu;Yu-Cheng Gu
Journal of The American Society for Mass Spectrometry 2013 Volume 24( Issue 5) pp:789-793
Publication Date(Web):2013 May
DOI:10.1007/s13361-013-0578-0
Non-target screening of veterinary drugs using tandem mass spectrometric data was performed on the SmartMass platform. This newly developed software uses the characteristic fragmentation patterns (CFP) to identify chemicals, especially those containing particular substructures. A mixture of 17 sulfonamides was separated by ultra performance liquid chromatography (UPLC), and SmartMass was used to process the tandem mass spectrometry (MS/MS) data acquired on an Orbitrap mass spectrometer. The data were automatically extracted, and each sulfonamide was recognized and analyzed with a prebuilt analysis rule. By using this software, over 98 % of the false candidate structures were eliminated, and all the correct structures were found within the top 10 of the ranking lists. Furthermore, SmartMass could also be used to identify slightly modified contraband drugs and metabolites with simple prebuilt rules.
Co-reporter:Dahai He;Xuemin Xu;Wenlong Deng;Bin Xia;Lisheng Ding
Helvetica Chimica Acta 2012 Volume 95( Issue 7) pp:1136-1143
Publication Date(Web):
DOI:10.1002/hlca.201100478
Abstract
Two new diterpenoids, loxocalyxin A (1) and 13-epiloxocalyxin A (2), and two new sesquiterpenoids, loxocalyxins B and C (3 and 4, resp.), together with three known compounds, were isolated from the MeOH extract of the whole plant of Loxocalyx urticifolius Hemsl. The structures of the new compounds were established by means of spectroscopic analysis including one- and two-dimensional NMR spectroscopy. All new structures were confirmed by X-ray crystallographic analysis. Their absolute configurations were established.
Co-reporter:Dahai He, Lisheng Ding, Hongxi Xu, Xinxiang Lei, Hongping Xiao, and Yan Zhou
The Journal of Organic Chemistry 2012 Volume 77(Issue 19) pp:8435-8443
Publication Date(Web):September 4, 2012
DOI:10.1021/jo301225v
Fifteen new lignans, gymnothelignans A–O (1–15), bearing tetrahydrofuran with variable conformations belonging to three potentially related skeletons were isolated from Gymnotheca chinensis Decne. The structures were elucidated by means of detailed spectroscopic analysis. Absolute configurations were assigned using X-ray single-crystal diffraction and chemical transformations. Moreover, by the homology, compounds 1–11 and eupomatilones were confirmed to have uniform R-configuration at C-5. However, a synthesized congener has long been mistaken as 5-epimer of eupomatilone-6. This work provides guidance for the absolute configuration establishment of the subeupomatilone family with trans-H-4–H-5 configuration.
Co-reporter:Kaijie Xu, Shunyuan Jiang, Yan Zhou, Yanxia Zhang, Bing Xia, Xuemin Xu, Yi Zhou, Yufei Li, Mingkui Wang, Lisheng Ding
Journal of Pharmaceutical and Biomedical Analysis 2011 56(5) pp: 1089-1093
Publication Date(Web):
DOI:10.1016/j.jpba.2011.07.034
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