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Yuan-feng Tong

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Organization: Institute of Materia Medica
Department: State Key Laboratory of Bioactive Substance and Function of Natural Medicines
Title:
Synthesis and cytotoxicity evaluation of a novel justicidin G analogue and its phosphate ester
Co-reporter:Sheng-Peng Wang, Yuan-Feng Tong, Dong-Mei Wang, Nan Wang, Zheng Yan, Ping Huang, Song Wu
Chinese Chemical Letters 2014 Volume 25(Issue 7) pp:1044-1046
Publication Date(Web):July 2014
DOI:10.1016/j.cclet.2014.05.042
The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps starting from commercially available methyl gallate and veratraldehyde. The cytotoxicity of the intermediates was tested against HCT-8, BEL-7402, KETR3, HELA, BGC-823, KB and MCF-7 cell lines by the MTT test, and compound 15 exhibited significant cytotoxicity in HELA and KB cell lines.A novel justicidin G analogue and its phosphate ester were synthesized and their cytotoxicity was screened.
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