Catalysis of silver nanoparticles, among the metal-based nanoparticles, has been of great interest in organic synthesis and has expanded rapidly in the past ten years because of nanosilver catalysts' unique reactivity and selectivity, stability, as well as recyclability in catalytic reactions. As can be seen from the research results reported in this critical review, the application of heterogeneous silver-based nanoparticles to general organic reactions has been proven to be an effective strategy in the development of highly efficient organic transformations in terms of efficiency and selectivity. In particular, this review revealed the strong potential of nanosilver catalysis in the total synthesis of natural products and pharmaceutical molecules.

A catalyst system of Sevelamer, a phosphate-binding drug, has been prepared and used in the Knoevenagel reaction of aromatic aldehydes in water to produce substituted electrophilic alkenes. The products were obtained in excellent yields. Several novel, related catalytic systems showed promising catalytic properties for aromatic and heterocyclic aldehydes. The Sevelamer catalyst can be recovered using simple filtration and reused numerous times (up to 15 times) in the aqueous Knoevenagel reaction without any significant lowering of activity.Sevelamer, as a phosphate-binding drug, was used as a novel and highly efficient catalyst in the Knoevenagel reaction in water. The Sevelamer, as catalyst, can be recovered and reused numerous times (up to 15 times) without any activity loss.

Catalysis of silver nanoparticles, among the metal-based nanoparticles, has been of great interest in organic synthesis and has expanded rapidly in the past ten years because of nanosilver catalysts' unique reactivity and selectivity, stability, as well as recyclability in catalytic reactions. As can be seen from the research results reported in this critical review, the application of heterogeneous silver-based nanoparticles to general organic reactions has been proven to be an effective strategy in the development of highly efficient organic transformations in terms of efficiency and selectivity. In particular, this review revealed the strong potential of nanosilver catalysis in the total synthesis of natural products and pharmaceutical molecules.