•New isoflavonoids and norneolignan were isolated from Caragana changduensis.•Norneolignan was firstly isolated from Caragana genus.•Structural elucidation was based on spectroscopic techniques (NMR, HRESIMS, UV, IR, CD).•Six known compounds were firstly separated from Caragana changduensis.Two new isoflavonoids, named 6,7,2′-trihydroxy-4′-methoxyisoflavone (1), 7,3′-dimethoxy-5′-hydroxyisoflavone (2), one new norneolignan, named (8S)-2,4-dihydroxy-8-hydroxymethyl-4′-methoxydeoxybenzoin (3); together with six known compounds, methyl 4-hydroxylbenzoate (4), ethyl 4-hydroxybenzoate (5), piceatannol (6), cararosin A (7), 2,4-dihydroxybenzoate (8), and 6,7,4′-trihydroxyisoflavone (9) were isolated from the red heartwood in the rhizomes of Caragana changduensis by using chromatographic methods Their structures were determined by extensive spectroscopic analysis and comparison of their spectral data with previous reported data.Download high-res image (227KB)Download full-size image

•Two new hemiterpene glycosides were isolated from the roots of Securidaca inappendiculata Hassk.•One new phenolic glycoside was isolated from the roots of S. inappendiculata.•Their chemical structures were determined by 1D, 2D NMR and HRESIMS experiments.•Hemiterpene glycosides, with aglycone 4-hydroxy-2-methylene-butyric acid, may be one of characteristic constituents of S. inappendiculata.Two new hemiterpene glycosides, named as securiterpenoside B (1), and securiterpenoside C (2), and one new phenolic glycoside, named as securiphenoside A (3) were isolated from the roots of Securidaca inappendiculata Hassk. Their structures were elucidated on the basis of 1D and 2D NMR data and HRESIMS and comparisons with published data. Moreover, compounds 1–3 were evaluated for cytotoxicities against A549 (Lewis lung cancer), Hela (human cervical cancer) and MCF-7 (human breast cancer) cell lines.Download high-res image (68KB)Download full-size image

•Three new acylated triterpene saponins were obtained from the roots of Securidaca inappendiculata Hassk.•Their chemical structures were elucidated on the basis of extensive 1D, 2D NMR and HRESIMS experiments.•Their cytotoxic activities were evaluated in Lewis lung cancer and MCF-7 (human breast cancer) cell lines.Two new acylated triterpene saponins, named as securioside C (1), securioside D (2), and one pair of isomers 3/4, the (Z)–isomer securioside E (3) being new, together with a known triterpene saponin polygalasaponin XLIV (4) were isolated from the roots of Securidaca inappendiculata Hassk. Their structures were established by HRESIMS, 1D and 2D NMR experiments and comparison of their NMR data with previous reported data. In addition, Compounds 1–2, 3/4, 4 were evaluated for cytotoxicities against LLC (Lewis lung carcinoma) and MCF-7 (human breast cancer) cell lines. Compounds 1 and 2 exhibited moderate cytotoxic activities against LLC cells with IC50 values of 45.56 μM and 85.98 μM.Download full-size image