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Kai Wang

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Name: 王凯; Kai Wang
Organization: Wuhan Institute of Technology
Department: Key Laboratory for Green Chemical Process of Ministry of Education
Title: Professor

TOPICS

Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation
Co-reporter:Kai Wang, Shuai-Hua Song, Yun-Man Zheng, Zao-Ying Li
Chinese Chemical Letters 2013 Volume 24(Issue 11) pp:1011-1013
Publication Date(Web):November 2013
DOI:10.1016/j.cclet.2013.07.018
5,10,15,20-Tetrakis(4-amidinophenyl)porphyrin (Por 1), its Zn complex (Por 2) and amidinophenyl bispophyrin (Por 3) interacting with calf thymus DNA were investigated by scanning electron microscopy (SEM) and the shape and size of the porphyrin–DNA complexes were observed after photo irradiation. The results showed that the shape and size of DNA had significant differences with blank group by virtue of the interaction between the porphyrins and ct-DNA. This suggests the morphological characterization could be used to study the interaction and judge DNA photocleavage activity indirectly through the photo irradiation of porphyrins.Morphological images, such as shape and size of porphyrins–DNA, were observed using scanning electron microscopy (SEM).
Fluorescent Properties of the Amidinophenylporphyrins Interacting with DNA
Co-reporter:Kai Wang;Tian Li;Faquan Yu;Yunman Zheng;Wai-Kwok Wong;Daniel W. J. Kwong;Zaoying Li
Chinese Journal of Chemistry 2012 Volume 30( Issue 3) pp:529-533
Publication Date(Web):
DOI:10.1002/cjoc.201100564

Abstract

5,10,15,20-Tetrakis(4-amidinolphenyl)porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes of luminescence were measured as a function of the nature to understand the interaction with DNA. The results suggest those amidinoporphyrins are promising new photodynamic therapeutic agents.

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