Four hydroxybenzamide derivatives were synthesized from protocatechuic acid. The antioxidant activities of these derivatives were evaluated in vitro using DPPH radical scavenging and reducing power assays. In addition, these compounds were subjected to a chromogenic thrombin-inhibitory assay using Chromozym-TH as the substrate. The anticancer effects of these derivatives were also investigated using the MTT assay in three human cancer cell lines. Four derivatives exhibited excellent DPPH radical scavenging activity and redox potential. Their highly inhibitory effect against thrombin may allow them to be utilized as novel micromolecule thrombin inhibitors. Furthermore, four derivatives demonstrated different inhibitory activities in three human cancer cell lines but showed minimal harmful effects on normal HUVEC cells. Therefore, hydroxybenzamide derivatives indicate the superior antioxidant, thrombin-inhibitory, and anticancer activities along with the excellent biocompatibility, which have the potential application in therapeutic interventions and disease prevention of cancer, thrombotic diseases, and aging.

•The innovation of bentonite and bentonite loading potassium sorbate coating mangos.•The characteristic of loading potassium sorbate was featured by SEM and XRD.•All indexes are eminent improvements. It inhibited decay and slowed ripening.•The flavor of mango slice was not affected by the coatings treatment.•The proposed methodology helps to comprehend the postharvest quality of mango.The use of bentonite coatings for mango preservation was investigated. Mangos were coated with bentonite and bentonite loaded with potassium sorbate at ambient temperature. The major properties of quality and physiology assessed including color change, decay index, weight loss, respiration intensity, soluble sugar content, titratable acidity, vitamin C content, soluble solids content, protopectin content, and soluble pectin content. Results indicated that mangos treated by either bentonite or bentonite loaded with potassium sorbate exhibited reduced decay, delayed postharvest ripening, decreased water loss, maintained high vitamin C levels, preserved titratable acidity, and no changes in flavor. These effects were greater for bentonite loaded with potassium sorbate than for pure bentonite. Overall results suggest that bentonite and bentonite loaded with potassium sorbate coatings could extend the shelf-life of mangos with optimum quality.