Shiguo Chen

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Organization: Shenzhen University

Department: College of Materials Science and Engineering

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Correction: A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells

Co-reporter:Yu-qing Niu;Tao He;Jun Song;Si-ping Chen;Xiang-yu Liu;Zhi-gang Chen;Ying-jie Yu;Shi-guo Chen

Chemical Communications 2017 vol. 53(Issue 59) pp:8376-8376

Publication Date(Web):2017/07/20

DOI:10.1039/C7CC90275A

Correction for ‘A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells’ by Yu-qing Niu et al., Chem. Commun., 2017, DOI: 10.1039/c7cc02555f.

Smart multifunctional polyurethane microcapsules for the quick release of anticancer drugs in BGC 823 and HeLa tumor cells

Co-reporter:Yuqing Niu;Florian J. Stadler;Tao He;Xingcai Zhang;Yingjie Yu

Journal of Materials Chemistry B 2017 vol. 5(Issue 48) pp:9477-9481

Publication Date(Web):2017/12/14

DOI:10.1039/C7TB02570J

Smart multifunctional drug delivery systems (DDSs) based on cytophilic fluorescent polyurethane copolymer microcapsules with high tumor cell internalization, triggered release, quick cancer cell death and real time fluorescent monitoring abilities is developed as a facile and versatile approach for precision cancer therapy.

A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells

Co-reporter:Yu-qing Niu;Tao He;Jun Song;Si-ping Chen;Xiang-yu Liu;Zhi-gang Chen;Ying-jie Yu;Shi-guo Chen

Chemical Communications 2017 vol. 53(Issue 54) pp:7541-7544

Publication Date(Web):2017/07/04

DOI:10.1039/C7CC02555F

A multi-block fluorescent amphiphilic polyurethane copolymer (TPE-PU), self-assembling into hairy, water-soluble micelles, is used as a subcellular microfilament probe in living cells.

Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing

Co-reporter:Xiangyu Liu, Yuqing Niu, Kevin C. Chen, Shiguo Chen

Materials Science and Engineering: C 2017 Volume 71() pp:289-297

Publication Date(Web):1 February 2017

DOI:10.1016/j.msec.2016.10.019

•Rapid hemostatic and mild PUUF wound dressing was fabricated.•Low-toxic PUUF exhibited good water uptake that could build a regional moist environment beneficial for wound healing.•PUUF could promote wound healing and enhance re-epithelialization.A novel rapid hemostatic and mild polyurethane-urea foam (PUUF) wound dressing was prepared by the particle leaching method and vacuum freeze-drying method using 4, 4-Methylenebis(cyclohexyl isocyanate), 4,4-diaminodicyclohexylmethane and poly (ethylene glycol) as raw materials. And X-ray diffraction (XRD), tensile test, differential scanning calorimetry (DSC) and thermogravimetry (TG) were used to its crystallinity, stress and strain behavior, and thermal properties, respectively. Platelet adhesion, fibrinogen adhesion and blood clotting were performed to evaluate its hemostatic effect. And H&E staining and Masson Trichrome staining were used to its wound healing efficacy. The results revealed the pore size of PUUF is 50–130 μm, and its porosity is 71.01%. Porous PUUF exhibited good water uptake that was benefit to adsorb abundant wound exudates to build a regional moist environment beneficial for wound healing. The PUUF wound dressing exhibit better blood coagulation effect than commercial polyurethane dressing (CaduMedi). Though both PUUF and CaduMedi facilitated wound healing generating full re-epithelialization within 13 days, PUUF was milder and lead to more slight inflammatory response than CaduMedi. In addition, PUUF wound dressing exhibited lower cytotoxicity than CaduMedi against NIH3T3 cells. Overall, porous PUUF represents a novel mild wound dressing with excellent water uptake, hemostatic effect and low toxicity, and it can promote wound healing and enhance re-epithelialization.

Enhanced water-solubility, antibacterial activity and biocompatibility upon introducing sulfobetaine and quaternary ammonium to chitosan

Co-reporter:Yuxiang Chen, Jianna Li, Qingqing Li, Yuanyuan Shen, Zaochuan Ge, Wenwen Zhang, Shiguo Chen

Carbohydrate Polymers 2016 Volume 143() pp:246-253

Publication Date(Web):5 June 2016

DOI:10.1016/j.carbpol.2016.01.073

•A novel reactive sulfobetaine with isocyanate group is proposed.•Represents a new method for improving antibacterial activity of chitosan (CS).•Novel CS derivatives with quaternary ammonium and sulfobetaine are presented.•Sulfobetaine can be used to improve water-solubility of CS and its derivatives.•Sulfobetaine can be used to improve biocompatibility of CS and its derivatives.Chitosan (CS) has attracted much attention due to its good antibacterial activity and biocompatibility. However, CS is insoluble in neutral and alkaline aqueous solution, limiting its biomedical application to some extent. To circumvent this drawback, we have synthesized a novel N-quaternary ammonium-O-sulfobetaine-chitosan (Q3BCS) by introducing quaternary ammonium compound (QAC) and sulfobetaine, and its water-solubility, antibacterial activity and biocompatibility were evaluated compare to N-quaternary ammonium chitosan and native CS. The results showed that by introducing QAC, antibacterial activities and water-solubilities increase with degrees of substitution. The largest diameter zone of inhibition (DIZ) was improved from 0 (CS) to 15 mm (N-Q3CS). And the water solution became completely transparent from pH 6.5 to pH 11; the maximal waters-solubility was improved from almost 0% (CS) to 113% at pH 7 (N-Q3CS). More importantly, by further introducing sulfobetaine, cell survival rate of Q3BCS increased from 30% (N-Q3CS) to 85% at 2000 μg/ml, which is even greater than that of native CS. Furthermore, hemolysis of Q3BCS was dropped sharply from 4.07% (N-Q3CS) to 0.06%, while the water-solution and antibacterial activity were further improved significantly. This work proposes an efficient strategy to prepare CS derivatives with enhanced antibacterial activity, biocompatibility and water-solubility. Additionally, these properties can be finely tailored by changing the feed ratio of CS, glycidyl trimethylammonium chloride and NCO-sulfobetaine.

Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt

Co-reporter:Dan Zhu, Honghao Cheng, Jianna Li, Wenwen Zhang, Yuanyuan Shen, Shaojun Chen, Zaochuan Ge, Shiguo Chen

Materials Science and Engineering: C 2016 Volume 61() pp:79-84

Publication Date(Web):1 April 2016

DOI:10.1016/j.msec.2015.12.024

•Preparation of novel chitosan derivatives bearing quaternary phosphonium (N-QPCS)•A new method for improving water-solubility and antibacterial activity of chitosan•Observing enhanced antibacterial activity against S. aureus and E. coli for N-QPCS•N-QPCS are obviously more soluble than chitosan at a wide pH range.•The antibacterial activities of N-QPCS are significantly better than that of chitosan.Chitosan (CS) has been widely recognized as an important biomaterial due to its good antimicrobial activity, biocompatibility and biodegradability. However, CS is insoluble in water in neutral and alkaline aqueous solution due to the linear aggregation of chain molecules and the formation of crystallinity. This is one of the key factors that limit its practical applications. Therefore, improving the solubility of CS in neutral and alkaline aqueous solution is a primary research direction for biomedical applications. In this paper, a reactive antibacterial compound (4-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-benzyl)-triphenyl-phosphonium bromide (NHS-QPS) was synthesized for chemical modification of CS, and a series of novel polymeric antimicrobial agents, N-quaternary phosphonium chitosan derivatives (N-QPCSxy, x = 1–2,y = 1–4) were obtained. The water solubilities and antibacterial activities of N-QPCSxy against Escherichia coli and Staphylococcus aureus were evaluated compare to CS. The water solubility of N-QPCSxy was all better than that of CS at neutral pH aqueous solution, particularly, N-QPCS14 can be soluble in water over the pH range of 3 to 12. The antibacterial activities of CS derivatives were improved by introducing quaternary phosphonium salt, and antibacterial activity of N-QPCSxy increases with degree of substitution. Overall, N-QPCS14 represents a novel antibacterial polymer material with good antibacterial activity, waters solubility and low cytotoxicity.N-quaternary phosphonium chitosan derivatives (N-QPCS) with different degrees of substitution were synthesized by introducing quaternary phosphonium salt that is synthesized via two step chemical reaction. Both antibacterial activities and solubility of N-QPCS were greatly improved comparing to that of chitosan.

Electroactive two-way shape memory polymer laminates

Co-reporter:Shaojun Chen;Shixin Yang;Ziyu Li;Shiwei Xu;Hongming Yuan;Zhaochuan Ge

Polymer Composites 2015 Volume 36( Issue 3) pp:439-444

Publication Date(Web):

DOI:10.1002/pc.22958

Two-way shape changing polymers are attractive in recent years. In this short communication, carbon black (CB)/shape memory polyurethane (SMPU)-elastic polyurethane (EPU) laminated composite is prepared and electro-active two-way shape changing behavior is reported for the first time. First, the CB/SMPU composite demonstrates good electro-active shape recovery due to good electricity conduction. When the CB/SMPU composite film is elongated and form polymer laminates by combining with EPU substrate, the resulted CB/SMPU-EPU polymer laminate shows electro-active two-way shape changing behavior, e.g., bending by applying electric current, and reverse bending upon cooling without electric current. POLYM. COMPOS. 36:439–444, 2015. © 2014 Society of Plastics Engineers

Development of shape memory polyurethane based on polyethylene glycol and liquefied 4,4-diphenylmethane diisocyanate using a bulk method for biomedical applications

Co-reporter:Funian Mo;Faxing Zhou;Shaojun Chen;Haipeng Yang;Zaochuan Ge

Polymer International 2015 Volume 64( Issue 4) pp:477-485

Publication Date(Web):

DOI:10.1002/pi.4814

Abstract

In this study, a series of shape memory polyurethanes (SMPUs) were synthesized successfully by the bulk polymerization method from liquefied 4,4′-diphenylmethane diisocyanate (L-MDI), 1,4-butanediol (BDO) and polyethylene glycol (PEG). The influence of the hard segment content (HSC) on the structure, morphology, properties and biocompatibility of PEG based SMPUs (PEGSMPUs) was carefully investigated. The results show that a microphase separation structure composed of a semicrystalline soft phase and an amorphous hard phase is formed in the PEG6000/L-MDI/BDO system. Crystallization of the PEG soft segment is influenced by the hard segments. The PEG semicrystalline soft phase serves as a reversible phase while the L-MDI−BDO hard segment acts as physical netpoints. Finally, a cyclic tensile test shows that all PEGSMPUs have good shape recovery (e.g. above 80%), whereas good shape fixity can only be achieved when the HSC is less than 35 wt%. The Cell Counting Kit 8 assay also demonstrates that only PEGSMPUs containing less than 40 wt% HSC have low cytotoxicity. It is thus concluded that PEGSMPUs bearing both good shape memory effects and good biocompatibility can be used as shape memory materials for biomedical applications when the HSC is less than 35 wt%. © 2014 Society of Chemical Industry

Electrochemical lithiation and delithiation performance of SnSb–Ag/carbon nanonube composites for lithium-ion batteries

Co-reporter:Peixin Zhang, Yanyi Wang, Yang Wang, Xiangzhong Ren, Kun Liu, Shiguo Chen

Journal of Power Sources 2013 Volume 233() pp:166-173

Publication Date(Web):1 July 2013

DOI:10.1016/j.jpowsour.2013.01.097

SnSb–Ag/Carbon nanonube (CNT) composites materials are synthesised using chemical reduction methods. The microstructure, morphologies and electrochemical properties of these materials are investigated by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), constant current charge/discharge tests and cyclic voltammetry tests. The results indicate that Ag promotes the entire charge–discharge process during the complex multi-step reaction process and, to some extent, prevent the reunion of nanoparticles. At the same time, CNTs, with a large space volume and form a network structure, prevent particles aggregation and increase the buffer space between the alloy particles, which greatly reduce the diffusion distance of lithium ions and the occurrence of lithium trapping in the active electrode materials. CNTs also have excellent mechanical properties and toughness, they effectively buffer enormous stresses during the volume expansion of alloy particles, weakening the forces between the particles and reducing the rate of formation of powder particles. All these factors cause the SnSbAg0.1/6% CNT composites exhibit excellent cycle life by controlling the lithiation of the anode material; the reversible capacity for the 50th cycle is 639.6 mAh g−1 between 0.05 and 1.5 V.Highlights► The coexistence of Ag and CNTs has synergetic effect on electrochemical properties. ► The ambient temperature affect the electrochemical properties. ► The CV curves and voltage profiles shows the cycle processes. ► The SEM micrographs show the relationship between structure and performance.

Facile preparation of shape memory polyurethanes by polyurethanes blending

Co-reporter:Shixing Yang;Hongmin Yuan;Jieling Luo;Shaojun Chen;Zaochuan Ge;Jiawei Zheng

Journal of Applied Polymer Science 2013 Volume 130( Issue 6) pp:4047-4053

Publication Date(Web):

DOI:10.1002/app.39682

ABSTRACT

This article presents a facile preparation method of shape memory polyurethane (SMPU) by polyurethane blending from commercial thermoplastic polyurethane (PUA) with designed polyurethane (PUB). Structure, morphology, and shape memory behaviors of SMPU blends are investigated systematically. The results show that the PUB and PUA are miscible in the SMPU blends. When the PUB content is higher than 40 wt %, the T_g of SMPU blends is adjusted to above room temperature. As the PUA content increases, the PUA phase changes gradually from a droplet-like dispersion phase to continuous soft phase, whereas the PUB phase changes from a continuous hard phase to a droplet-like dispersion hard phase. SMPU blends show good shape memory effect when the PUA is blended with more than 40 wt % PUB. Thus, the commercialization of SMPU can be promoted greatly through the polyurethane blending from the commercial thermoplastic polyurethanes with polyurethane containing higher hard segment content. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4047–4053, 2013

Facile preparation and synergistic antibacterial effect of three-component Cu/TiO2/CS nanoparticles

Co-reporter:Shiguo Chen, Yujuan Guo, Shaojun Chen, Huimin Yu, Zaochuan Ge, Xuan Zhang, Peixin Zhang and Jiaoning Tang

Journal of Materials Chemistry A 2012 vol. 22(Issue 18) pp:9092-9099

Publication Date(Web):26 Mar 2012

DOI:10.1039/C2JM00063F

Due to the outbreaks of infectious diseases caused by different pathogenic bacteria and development of antibiotic resistance, researchers are actively searching for new antibacterial agents. Synergistic antibacterial effects provide a new way to prepare antibacterial systems to fight resistant bacteria. In this study, novel copper (Cu)/titanium dioxide (TiO2)/chitosan (CS) (CTC) three-component nanoparticles were facilely prepared via photocatalytic reduction on the basis of the synergistic antibacterial principle. The structure, antibacterial activity and antibacterial mechanism of CTC were investigated systematically. The results showed that this hybrid material exhibits excellent antibacterial ability against Escherichia coli and Staphylococcus aureus due to the synergistic antibacterial effect of the Cu, TiO2 and CS components in the nanoparticles. The minimal inhibition concentrations (MIC) of CTC against E. coli and S. aureus are only 5.22 μg mL−1 and 2.61 μg mL−1, respectively, much lower than the two-component systems. Thus, the encouraging results presented in this study demonstrate great potential applications of CTC as an alternative candidate for an antibacterial agent with high antibacterial activity.

Fabrication of Cu/TiO2 nanocomposite: Toward an enhanced antibacterial performance in the absence of light

Co-reporter:Shiguo Chen, Yujuan Guo, Shaojun Chen, Zaochuan Ge, Haipeng Yang, Jiaoning Tang

Materials Letters 2012 Volume 83() pp:154-157

Publication Date(Web):15 September 2012

DOI:10.1016/j.matlet.2012.06.007

Incorporation of nanoparticles is becoming a new strategy for improving antibacterial activity. In this paper, Copper (Cu)/titanium dioxide (TiO2) (CTD) nanocomposite was easily prepared by photocatalytic reduction, and its structure as well as antibacterial activity in the absence of light was investigated in detail. The results show that the CTD nanocomposite exhibits good antibacterial activity even in the absence of light. The minimal inhibition concentration against Escherichia coli and Staphylococcus aureus is 21.4 μg/mL and 14.3 μg/mL, respectively, which are much lower than that of pure silver, Cu and TiO2 nanoparticles. In addition, the enhanced antibacterial effect of the CTD nanocomposite may be explained by synergistic antibacterial effect.Highlights► CTD composite was facile synthesized by photocatalytic reduction. ► CTD exhibits excellent antibacterial activity due to synergistic effect. ► The antibacterial mechanism of CTD is bactericidal by disrupting cell wall.

Studies on the thermal stability of polyurethanes containing pyridine: Thermogravimetric analysis

Co-reporter:Shaojun Chen, Haitao Zhuo, Shiguo Chen, Zaochuan Ge, Hongming Yuan, Jieling Luo

Thermochimica Acta 2012 Volume 543() pp:281-287

Publication Date(Web):10 September 2012

DOI:10.1016/j.tca.2012.06.009

Recently, pyridine containing polyurethanes (PUPys) are attractive to fabricate supramolecular polymer networks. In this paper, thermogravimetric analysis was used to investigate thermal stability of PUPys quantitatively. The results show that the PUPys have at least two stages of degradation. The thermal stability of PUPys is better under oxygen as compared with nitrogen. PUPys based on hexamethylene diisocyanate tends to have higher onset decomposition temperature, but lower end decomposition temperature as compared with PUPys based on diphenylmethane diisocyanate (MDI). The PUPys with lower pyridine unit content have improved thermal stability at lower temperature range. The addition of rigid hard segment improves the decomposition temperature of pyridine unit, but promotes the weight loss at higher temperature range. Finally, it is proposed that the thermo-oxidative degradation of PUPys might be explained with the association of pyridine ring with hydrogen atom or hydroperoxides.Highlights▸ We investigated the pyridine containing polyurethanes using TGA. ▸ HDI based PUPys have higher Ti, but lower Te. ▸ Lower BINA content PUPys improved thermal stability at lower temperature. ▸ MDI–BDO hard segment improves the decomposition temperature of BINA unit. ▸ Thermo-oxidative degradation mechanism is associated with the hydrogen bonding of pyridine.

Environmentally Friendly Antibacterial Cotton Textiles Finished with Siloxane Sulfopropylbetaine

Co-reporter:Shiguo Chen, Shaojun Chen, Song Jiang, Meiling Xiong, Junxuan Luo, Jiaoning Tang, and Zaochuan Ge

ACS Applied Materials & Interfaces 2011 Volume 3(Issue 4) pp:1154

Publication Date(Web):March 21, 2011

DOI:10.1021/am101275d

This paper reports a novel environmentally friendly antibacterial cotton textile finished with reactive siloxane sulfopropylbetaine(SSPB). The results show that SSPB can be covalently bound onto the cotton textile surface, imparting perdurable antibacterial activity. The textiles finished with SSPB have been investigated systematically from the mechanical properties, thermal stability, hydrophilic properties and antibacterial properties. It is found that the hydrophilicity and breaking strength are improved greatly after the cotton textiles are finished with SSPB. Additionally, the cotton textiles finished with SSPB exhibit good antibacterial activities against gram-positive bacteria Staphylococcus aureus (S.aureus, ATCC 6538), gram-negative bacteria Escherichia coli (E.coli, 8099) and fungi Candida albicans (C.albicans, ATCC 10231). Moreover, SSPB is nonleachable from the textiles, and it does not induce skin stimulation and is nontoxic to animals. Thus, SSPB is ideal candidate for environmentally friendly antibacterial textile applications.Keywords: antimicrobial; betaine; environmentally friendly; finishing; siloxane; textile

Synthesis and characterization of siloxane sulfobetaine antimicrobial agents

Co-reporter:Shiguo Chen, Shaojun Chen, Song Jiang, Yangmiao Mo, Jiaoning Tang, Zaochuan Ge

Surface Science 2011 Volume 605(11–12) pp:L25-L28

Publication Date(Web):June 2011

DOI:10.1016/j.susc.2011.03.013

In this paper, we report a novel antibacterial agent siloxane sulfobetaine (SSB) with reactive siloxane groups, which can be bonded onto the glass surface, rendering excellent antibacterial activity and good durability. Their antibacterial rate against Escherichia Coli and Staphylococcus aureus reach 99.96% and 99.98%, respectively, within the 24 h contact time. Their antibacterial rates of SSB coated glass surface are still beyond 95.0% after 20 washes. Moreover, SSB does not induce a skin reaction and is nontoxic to animals. Therefore, the SSB has great applications in biomaterial applications requiring durable bacteriostasis.Novel siloxane sulfobetaine antibacterial agent without stimulation and toxicity is synthesized for bound biomaterial application requiring durable bacteriostasis.Research highlights► We had synthesized a novel kind of antibacterial agent siloxane sulfobetaine. ► The SSB contains quaternary ammonium and reactive siloxane groups. ► The antibacterial rate of SSB coated glass is higher than 99.96% within 24 h. ► The antibacterial rate of resultant surface is higher than 95.0% after washing. ► No skin stimulation and no toxicity to animal are found in the SSB.

Study of zwitterionic sulfopropylbetaine containing reactive siloxanes for application in antibacterial materials

Co-reporter:Shiguo Chen, Shaojun Chen, Song Jiang, Yangmiao Mo, Junxuan Luo, Jiaoning Tang, Zaochuan Ge

Colloids and Surfaces B: Biointerfaces 2011 Volume 85(Issue 2) pp:323-329

Publication Date(Web):1 July 2011

DOI:10.1016/j.colsurfb.2011.03.004

Antibacterial agents receive a great deal of attention around the world due to the interesting academic problems of how to combat bacteria and of the beneficial health, social and economic effects of successful agents. Scientists are actively developing new antibacterial agents for biomaterial applications. This paper reports the novel antibacterial agent siloxane sulfopropylbetaine (SSPB), which contains reactive alkoxysilane groups. The structure and properties of SSPB were systematically investigated, with the results showing that SSPB contains both quaternary ammonium compounds and reactive siloxane groups. SSPB has good antibacterial activity against both Escherichia coli (E. coli, 8099) and Staphylococcus aureus (S. aureus, ATCC 6538). The minimal inhibition concentration is 70 μmol/ml SSPB against both E. coli and S. aureus. In addition, the SSPB antibacterial agent can be used in both weak acid and weak alkaline environments, functioning within the wide pH range of 4.0–9.0. The SSPB-modified glass surface killed 99.96% of both S. aureus and E. coli organisms within 24 h. No significant decrease was observed in this antibacterial activity after 20 washes. Moreover, SSPB does not induce a skin reaction and is nontoxic to animals. Thus, SSPB is an ideal candidate for future applications as a safe, environmentally friendly antibacterial agent.Graphical abstractNovel siloxane sulfobetaine antibacterial agent without skin stimulation and toxicity is synthesized for potential biomaterial application requiring durable bacteriostasis.Highlights► The SSPB contains both QACs and reactive siloxane for durable antibacterial materials. ► The SSPB has good antibacterial activity with MIC of 70 μmol/ml and broad pH application range. ► The SSPB modified glass surface shows durable antibacterial activity. ► The antibacterial mechanism of SSPB may be bacteriostasis, but not bactericidal mechanism. ► The SSPB show no skin stimulation and nontoxic to animals.

Facile fabrication of polyurethane microcapsules carriers for tracing cellular internalization and intracellular pH-triggered drug release

Co-reporter:Yuqing Niu, Florian J. Stadler, Jun Song, Siping Chen, Shiguo Chen

Colloids and Surfaces B: Biointerfaces (1 May 2017) Volume 153() pp:

Publication Date(Web):1 May 2017

DOI:10.1016/j.colsurfb.2017.02.018

•Traceable pH-sensitive multifunctional PU microcapsules were fabricated.•The microcapsules can be readily internalized by cancer cells within a short time.•These carriers can quickly release DOX in acidic organelles.•Its dual-fluorescence emission facilitates real-time tracking and monitoring.A tailor-made traceable pH-sensitive drug delivery system based on polyurethane (PU) microcapsules was fabricated using a facile double-emulsion method containing 3,3′-dioctadecyloxacarbocyanine perchlorate, doxorubicin (DOX) and sodium bicarbonate (NaHCO3). When PU microcapsules were immersed in acidic media, NaHCO3 could react with the H+ to quickly produce CO2 bubbles to puncture the PU shell, resulting in rapid release of DOX to promptly reach the intracellular drug therapeutic threshold to kill cancer cells in a short period. Confocal laser scanning microscopic analysis showed that these traceable pH-sensitive drug carriers can be easily internalized by BGC 823 and Hela cells, and the loaded DOX can quickly release from PU microcapsules in the endo-/lysosomes to be mainly resided in cell nuclei. This traceable pH-sensitive drug carrier can achieve on-demand controlled release profiles for visualization of cancer therapy. Thus, it is a potential candidate for anticancer drug delivery system in advanced cancer therapy.

Facile preparation and synergistic antibacterial effect of three-component Cu/TiO2/CS nanoparticles

Co-reporter:Shiguo Chen, Yujuan Guo, Shaojun Chen, Huimin Yu, Zaochuan Ge, Xuan Zhang, Peixin Zhang and Jiaoning Tang

Journal of Materials Chemistry A 2012 - vol. 22(Issue 18) pp:NaN9099-9099

Publication Date(Web):2012/03/26

DOI:10.1039/C2JM00063F

Correction: A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells

Co-reporter:Yu-qing Niu, Tao He, Jun Song, Si-ping Chen, Xiang-yu Liu, Zhi-gang Chen, Ying-jie Yu and Shi-guo Chen

Chemical Communications 2017 - vol. 53(Issue 59) pp:NaN8376-8376

Publication Date(Web):2017/07/12

DOI:10.1039/C7CC90275A

Correction for ‘A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells’ by Yu-qing Niu et al., Chem. Commun., 2017, DOI: 10.1039/c7cc02555f.

A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells

Co-reporter:Yu-qing Niu, Tao He, Jun Song, Si-ping Chen, Xiang-yu Liu, Zhi-gang Chen, Ying-jie Yu and Shi-guo Chen

Chemical Communications 2017 - vol. 53(Issue 54) pp:NaN7544-7544

Publication Date(Web):2017/06/09

DOI:10.1039/C7CC02555F

A multi-block fluorescent amphiphilic polyurethane copolymer (TPE-PU), self-assembling into hairy, water-soluble micelles, is used as a subcellular microfilament probe in living cells.