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Wenshe Liu

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Organization: Texas A&M University
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Title:
Genetic incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications
Co-reporter:Ying Huang, Wei Wan, William K. Russell, Pei-Jing Pai, Zhiyong Wang, David H. Russell, Wenshe Liu
Bioorganic & Medicinal Chemistry Letters 2010 Volume 20(Issue 3) pp:878-880
Publication Date(Web):1 February 2010
DOI:10.1016/j.bmcl.2009.12.077
2-Amino-8-oxononanoic acid has been genetically incorporated into proteins in Escherichia coli by the use of an evolved pyrrolysyl-tRNA synthetase/pylT pair. The direct usage of the exclusive reactivity of the keto group in this amino acid with hydrazide- and alkoxyamine-bearing compounds to site-specifically label proteins under a mild condition close to physiological pH exhibited a very high efficiency.
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