Shang-Hui Ye

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Name: 尹桂

Organization: Nanjing University , China

Department: School of Chemistry and Chemical Engineering

Title: NULL(PhD)

TOPICS

Material Chemistry

OLED

Organic Chemistry

OLED

Chemicals
References

Selective imaging of cancer cells with a pH-activatable lysosome-targeting fluorescent probe

Co-reporter:Rongguang Shi, Lu Huang, Xiaoxue Duan, Guohao Sun, Gui Yin, Ruiyong Wang, Jun-jie Zhu

Analytica Chimica Acta 2017 Volume 988(Volume 988) pp:

Publication Date(Web):2 October 2017

DOI:10.1016/j.aca.2017.07.055

•The fluorescent probe NBOH showed superior performance for pH detection in a wide pH range with relatively long emission wavelength.•This probe exhibited strong anti-interference ability, photostability and remarkable reversibility.•Flow cytometry study was carried out showing quantitatively that fluorescence intensity of probe NBOH in cancer cells is nearly tenfold of it in normal cells.•Fluorescence imaging of nude mouse indicated the probe can distinguish tumor tissue out of normal tissue in vivo.•The probe exhibited potential application in cancer removal surgery.Fluorescence imaging with tumor-specific fluorescent probe has emerged as a tool to aid surgeons in the identification and removal of tumor tissue. We report here a new lysosome-targeting fluorescent probe (NBOH) with BODIPY fluorephore to distinguish tumor tissue out of normal tissue based on different pH environment. The probe exhibited remarkable pH-dependent fluorescence behavior in a wide pH range from 3.0 to 11.0, especially a sensitive pH-dependent fluorescence change at pH range between 3.5 and 5.5, corresponding well to the acidic microenvironment of tumor cells, in aqueous solution. The response time of NBOH was extremely short and the photostability was proved to be good. Toxicity test and fluorescence cell imaging together with a sub-cellular localization study were carried out revealing its low biotoxicity and good cell membrane permeability. And NBOH was successfully applied to the imaging of tumor tissue in tumor-bearing mice suggesting potential application to surgery as a tumor-specific probe.Download high-res image (209KB)Download full-size image

A ratiometric fluorescent probe for ferric ion based on a 2,2′-bithiazole derivative and its biological applications

Co-reporter:Jiao Geng, Yuan Liu, Jianhui Li, Gui Yin, Wei Huang, Ruiyong Wang, Yiwu Quan

Sensors and Actuators B: Chemical 2016 Volume 222() pp:612-617

Publication Date(Web):January 2016

DOI:10.1016/j.snb.2015.08.076

•The probe displays a quick response for Fe3+ over a broad pH ranges.•Fe2+ can be detected by adding an oxidant like Na2O2 or H2O2.•Zebrafish imaging experiments demonstrate its value on the practical applications for biological systems.•A new bithiazole-based ratiometric fluorescent chemosensor for detecting Fe3+.A new bithiazole-based ratiometric fluorescent chemosensor 4,4′-n-butyl-5,5′-(pyridin-4-yl)-2,2′-bithiazol (L) is prepared and its metal ion sensing properties have been investigated. It exhibits high sensitivity and selectivity toward Fe3+ among a series of metal ions in EtOH: H2O (9:1, v/v). The probe displays a quick response for Fe3+ over a broad pH range, and the presence of Fe2+ can also be detected by adding an oxidant like Na2O2 or H2O2. The association constant of resultant [FeL2] cation is calculated to be 2.76 × 103 M−2, and the detection limit for Fe3+ is found to be 0.6 μM. The living cell and zebrafish imaging experiments demonstrate its value on the practical applications for biological systems.A new bithiazole-based ratiometric fluorescent chemosensor L exhibits high sensitivity and selectivity toward Fe3+. The detection limit for Fe3+ is found to be 0.6 μM. The living cell and zebrafish imaging experiments demonstrate its value on the practical applications for biological systems.

A colorimetric and ratiometric fluorescent probe for ClO− targeting in mitochondria and its application in vivo

Co-reporter:Hongde Xiao, Jianhui Li, Jin Zhao, Gui Yin, Yiwu Quan, Jie Wang and Ruiyong Wang

Journal of Materials Chemistry A 2015 vol. 3(Issue 8) pp:1633-1638

Publication Date(Web):07 Jan 2015

DOI:10.1039/C4TB02003K

A colorimetric and ratiometric fluorescent probe PMN–TPP for imaging mitochondrial ClO− was prepared. The selectivity of PMN–TPP was excellent and the detection would not be influenced by other ROS. The limit of detection (LOD = 3σ/slope) for ClO− was evaluated to be 0.43 μM, suggesting the probe's high sensitivity to ClO−. For the biological applications, PMN–TPP performed well in detecting endogenous HClO in living RAW264.7 macrophage cells. A co-localization study employing Mito Tracker green revealed that PMN–TPP was specifically located in the mitochondria of living RAW264.7 macrophage cells. In the in vivo experiment, a nude mouse with acute inflammation stimulated by lipopolysaccharide (LPS) was employed. After injection of PMN–TPP, the fluorescence signal changed gradually in 30 min and then remained unchanged in the injection region, demonstrating that PMN–TPP could detect the endogenous HClO in living animals.

Macrospirocyclic Oligomer Based on Triphenylamine and Diphenylphosphine Oxide as a Bipolar Host for Efficient Blue Electrophosphorescent Organic Light-Emitting Diodes (OLEDs)

Co-reporter:Kun Chen, Hui-Ru Zhao, Zhao-Kang Fan, Gui Yin, Qing-Min Chen, Yi-Wu Quan, Shu-Hua Li, and Shang-Hui Ye

Organic Letters 2015 Volume 17(Issue 6) pp:1413-1416

Publication Date(Web):February 27, 2015

DOI:10.1021/acs.orglett.5b00292

A novel bipolar oligomer (TPA-PO)3 was prepared as a host material for efficient blue phosphorescent organic light-emitting diodes (OLEDs). Through the C-9s of the fluorene units, three triphenylamine units attached to diphenylphosphine oxide are connected in series to form a macrocyclic structure. The solution-processed phosphorescent device based on FIrpic and (TPA-PO)3 achieved a maximum current efficiency of 19.4 cd A–1 and a maximum luminance of 11 500 cd m–2 with a relatively low efficiency roll-off.

A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse

Co-reporter:Hongde Xiao, Kai Xin, Haifang Dou, Gui Yin, Yiwu Quan and Ruiyong Wang

Chemical Communications 2015 vol. 51(Issue 8) pp:1442-1445

Publication Date(Web):02 Dec 2014

DOI:10.1039/C4CC07411D

A very fast-responsive fluorescent probe PZ–Py for imaging mitochondrial HClO/ClO−, with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ–Py was successfully applied in the imaging of endogenous HClO/ClO− in the mitochondria of RAW 264.7 cells and living nude mouse.

A turn-on BODIPY-based fluorescent probe for Hg(II) and its biological applications

Co-reporter:Hongde Xiao, Jianhui Li, Kaitian Wu, Gui Yin, Yiwu Quan, Ruiyong Wang

Sensors and Actuators B: Chemical 2015 213() pp: 343-350

Publication Date(Web):

DOI:10.1016/j.snb.2015.02.105

Designs, Synthesis, Characterization and Direct Electrochemistry of Zinc-Porphyrin Bearing Pyrene Noncovalent Functionalized Graphene Oxide Sheet

Co-reporter:Chun Bi;Yongjie Li;Haowen Chen;Gui Yin;Junjie Zhu

Chinese Journal of Chemistry 2012 Volume 30( Issue 8) pp:1722-1728

Publication Date(Web):

DOI:10.1002/cjoc.201200282

Abstract

We have designed and synthesis a new compound of zinc-porphyrin bearing four pyrene groups (ZnP-t-P(py)₄) and prepared a new hybrid materials of ZnP-t-P(py)₄ with graphene oxide (GO) via non-covalent interactions. The ZnP-t-P(py)₄, along with four pendant pyrene entities ZnP-t-P(py)₄, stacking on the (GO) surface due to π- π interactions, has been revealed by AFM measurements. FTIR, UV-vis absorption confirm the non-covalent functionalization of the GO. Raman spectral measurements revealed the electronic structure of the GO to be intact upon hybrid formation. In this donor-acceptor nanohybrid, the fluorescence of photoexcited ZnP-t-P(py)₄ is effectively quenched by a possible electron-transfer process. The fluorescence and photoelectrical response measurements also showed that this hybrid may act as an efficient photoelectric conversion material for optoelectronic applications.

Donor-Acceptor Compound Based on Rhodanineacetic Acid-Pyrene Derivative: Red-Light Emitting Fluorescent Organic Nanoparticles

Co-reporter:Bo Zhang;Wei Diao;Chun Bi;Jian Sun;Guoxia Han;Yi Shi

Journal of Fluorescence 2012 Volume 22( Issue 1) pp:1-7

Publication Date(Web):2012 January

DOI:10.1007/s10895-011-0951-y

A donor-acceptor compound based on Rhodanineacetic acid-pyrene derivative (RAAP), which emits weak yellow-green fluorescence in the methanol solution, was investigated. RAAP nanoparticles with a mean diameter of 50–60 nm were prepared by a simple reprecipitation method without surfactants. The observation of RAAP nanoparticles were undertaken through SEM and TEM method. The emission spectra of RAAP nanoparticles are red-shifted (Δ λem = 86 nm) to red region and the intensity is 40-fold higher than that in the methanol solution. Both the J-aggregation and aggregation-induced intramolecular planarization are considered to be the probable mechanism of strong emission for RAAP nanoparticles. The excellent sensibility toward organic vapor which profits from its fluorescence switching behavior is well demonstrated by vapor experiment.

Fluorescence turn-on of easily prepared fluorescein derivatives by zinc cation in water and living cells

Co-reporter:Li Jiang, Ling Wang, Min Guo, Gui Yin, Rui-Yong Wang

Sensors and Actuators B: Chemical 2011 Volume 156(Issue 2) pp:825-831

Publication Date(Web):August 2011

DOI:10.1016/j.snb.2011.02.048

By combining a sulfonated β-naphtol as receptor, a hydrophilic fluorescence probe with extreme sensitivity (7 ppb) and selectivity for zinc ion has been designed and synthesized in a simple and efficient way. Based on the inhibition of internal charge transfer (ICT) process, This “turn-on” type fluorescent sensor molecule features high fluorescence increase (13 fold) at 508 nm as well as a red-shift from 371 to 430 nm over most competitive heavy and transition metal (HTM) ions in water (pH 7.4). Furthermore, cell imaging experiments show that this fluorescence probe might be used for monitoring Zn2+ within biological samples. The role of this sensor molecule in living cells was further confirmed with the treatment of N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine. And the impact of water-solubility and liposolubility of such fluorescence probe on biological application has been deeply discussed.

Cell Compatible Fluorescent Chemosensor for Hg2+ with High Sensitivity and Selectivity Based on the Rhodamine Fluorophore

Co-reporter:Li Jiang;Ling Wang;Bo Zhang;Gui Yin;Rui-Yong Wang

European Journal of Inorganic Chemistry 2010 Volume 2010( Issue 28) pp:04438-4443

Publication Date(Web):

DOI:10.1002/ejic.201000512

Abstract

An easily prepared “turn-on”-type fluorescent chemosensor for mercury based on Rhodamine-B, which exhibits high sensitivity and selectivity over other metal ions in aqueous systems, was obtained. The distinctive wavelengths in the UV/Vis absorption range can sense Hg²⁺, Cu²⁺, and Fe³⁺ separately. Furthermore, this “turn-on”-type fluorescent sensor, upon the addition of Hg²⁺ over other competitive species, was successfully applied to bioimaging in yeast and HeLa cells. The potential of these types of chemosensors for use in environmental and biological systems is great.

New Azobenzene Dye Colorimetric and Ratiometric Chemosensors for Mercury(II) Ion

Co-reporter:Min Guo;Wei Xue;Mingyun Guan;Jianhua Sun;Gui Yin

Chinese Journal of Chemistry 2009 Volume 27( Issue 9) pp:1773-1776

Publication Date(Web):

DOI:10.1002/cjoc.200990298

Abstract

A new series of azobenzene dyes, which possessed colorimetric and ratiometric recognition to Hg²⁺ based on the mechanism of internal charge transfer (ICT), was developed and characterized. The molecules involving azo and imino functional groups can coordinate with Hg²⁺ to result in a large blue shift from 453 to 363 nm corresponding to a notable color change from orange to pale yellow in aqueous methanol solution (H₂O/CH₃OH=1/4, V/V), which can be applied to naked eye detection of Hg²⁺. The sensitivity, selectivity and binding mode of the sensors to Hg²⁺ were investigated by UV-Vis spectroscopy.

Self-repairing and superhydrophobic film of gold nanoparticles and fullerene pyridyl derivative based on the self-assembly approach

Co-reporter:Gui Yin, Wei Xue, Fasheng Chen, Xin Fan

Colloids and Surfaces A: Physicochemical and Engineering Aspects 2009 340(1–3) pp: 121-125

Publication Date(Web):

DOI:10.1016/j.colsurfa.2009.03.014

A colorimetric and ratiometric fluorescent probe for ClO− targeting in mitochondria and its application in vivo

Co-reporter:Hongde Xiao, Jianhui Li, Jin Zhao, Gui Yin, Yiwu Quan, Jie Wang and Ruiyong Wang

Journal of Materials Chemistry A 2015 - vol. 3(Issue 8) pp:NaN1638-1638

Publication Date(Web):2015/01/07

DOI:10.1039/C4TB02003K

A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse

Co-reporter:Hongde Xiao, Kai Xin, Haifang Dou, Gui Yin, Yiwu Quan and Ruiyong Wang