Co-reporter:Guangyin Qian, Xiaohu Hong, Bingxin Liu, Hong Mao, and Bin Xu
Organic Letters 2014 Volume 16(Issue 20) pp:5294-5297
Publication Date(Web):September 24, 2014
DOI:10.1021/ol502447w
An unexpected rhodium-catalyzed regioselective C–H chlorination of 7-azaindoles was developed using 1,2-dichloroethane (DCE) as a chlorinating agent and 7-azaindole as the directing group. This protocol provides an efficient access to ortho-chlorinated azaindoles with operational simplicity, good functional group tolerance, and a wide substrate scope.