XiaoDong Xing

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Name: 邢晓东; XiaoDong Xing

Organization: Nanjing University of Science and Technology , China

Department: School of Chemical Engineering

Title: Associate Researcher/Professor(PhD)

TOPICS

Applied Chemistry

Bactericide

Chemicals
References

Mussel-inspired deposition of copper on titanium for bacterial inhibition and enhanced osseointegration in a periprosthetic infection model

Co-reporter:Lei Wang;Xing Yang;Weiwei Cao;Chen Shi;Pinghui Zhou;Qiang Li;Fengxuan Han;Junying Sun;Bin Li

RSC Advances (2011-Present) 2017 vol. 7(Issue 81) pp:51593-51604

Publication Date(Web):2017/11/02

DOI:10.1039/C7RA10203H

Periprosthetic infection represents one of the most devastating complications in orthopedic surgeries. Implants that have both anti-bacterial and bone-forming capability and may function to simultaneously clear infection and repair bone defect, therefore, are highly desirable. In this study, titanium (Ti) substrates were fabricated deposited with different amounts of copper (Cu) using polydopamine (PDA)-based chemical modification technology. In vitro, Ti implants that were treated with PDA and deposited with Cu (Ti-PDA-Cu) showed excellent antibacterial performance against both S. aureus and E. coli compared with pristine Ti. They also markedly promoted adhesion and spreading of MC3T3-E1 cells, implying good biocompatibility of such Ti-PDA-Cu materials. In vivo, results from an animal model of implant-related osteomyelitis clearly demonstrated that Ti-PDA-Cu implants not only effectively inhibited bacterial infection, but also promoted osseointegration at the bone/implant interface. Taken together, these findings show that Ti-PDA-Cu possesses outstanding biocompatibility and antibacterial activity, and are candidate materials for preventing periprosthetic infection.

Development of a novel resin-based dental material with dual biocidal modes and sustained release of Ag+ ions based on photocurable core-shell AgBr/cationic polymer nanocomposites

Co-reporter:Weiwei Cao;Yu Zhang;Xi Wang;Yinyan Chen

Journal of Materials Science: Materials in Medicine 2017 Volume 28( Issue 7) pp:103

Publication Date(Web):22 May 2017

DOI:10.1007/s10856-017-5918-3

Research on the incorporation of cutting-edge nano-antibacterial agent for designing dental materials with potent and long-lasting antibacterial property is demanding and provoking work. In this study, a novel resin-based dental material containing photocurable core-shell AgBr/cationic polymer nanocomposite (AgBr/BHPVP) was designed and developed. The shell of polymerizable cationic polymer not only provided non-releasing antibacterial capability for dental resins, but also had the potential to polymerize with other methacrylate monomers and prevented nanoparticles from aggregating in the resin matrix. As a result, incorporation of AgBr/BHPVP nanocomposites did not adversely affect the flexural strength and modulus but greatly increased the Vicker’s hardness of resin disks. By continuing to release Ag+ ions without the impact of anaerobic environment, resins containing AgBr/BHPVP nanoparticles are particularly suitable to combat anaerobic cariogenic bacteria. By reason of the combined bactericidal effect of the contact-killing cationic polymers and the releasing-killing Ag+ ions, AgBr/BHPVP-containing resin disks had potent bactericidal activity against S. mutans. The long-lasting antibacterial activity was also achieved through the sustained release of Ag+ ions due to the core-shell structure of the nanocomposites. The results of macrophage cytotoxicity showed that the cell viability of dental resins loading less than 1.0 wt% AgBr/BHPVP was close to that of neat resins. The AgBr/BHPVP-containing dental resin with dual bactericidal capability and long term antimicrobial effect is a promising material aimed at preventing second caries and prolonging the longevity of resin composite restorations.Open image in new window

Facile synthesis of cationic polymer functionalized nanodiamond with high dispersity and antibacterial activity

Co-reporter:Weiwei Cao;Xuefeng Peng;Xiaoqin Chen;Xi Wang;Feng Jin

Journal of Materials Science 2017 Volume 52( Issue 4) pp:1856-1867

Publication Date(Web):2017 February

DOI:10.1007/s10853-016-0475-6

In this work, a cationic polymer, N-alkylated poly (4-vinylpyridine) was applied for the surface functionalization of nanodiamond (ND). The facile route not only settled the problems of agglomeration and poor dispersion stability of ND but also rendered the nanomaterial antibacterial property. Chemical modification of the particles was confirmed by FT-IR spectroscopy and 1HNMR, and the cationic polymer contents were determined by TGA studies. The particle diameters and dispersity of functionalized NDs were investigated by TEM and DLS measurements. It was found that extremely tight core aggregates (100–200 nm) were broken into tiny nanoparticles (20–30 nm) through functionalization with NPVP-propyl or NPVP-hexyl, which gave stable and homogeneous functionalized ND particles in colloidal solution. The antibacterial tests against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) showed that the cationic polymer-modified ND exerted certain antibacterial activity. The FE-SEM images indicated that NPVP-hexyl-ND particles were attached to the cell wall surface of E. coli, which subsequently led to the formation of nanoscale holes on cell membrane and eventually the serious destruction of cell wall. We suspected that the interaction of NPVP-hexyl-ND with bacteria may come from the electrostatic interactions, the intermolecular and surface forces between functionalized nanoparticles and cell membranes, which may damage the outer membranes of bacteria and result in cell death.

Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing

Co-reporter:Huinan Chen, Xiaodong Xing, Huaping Tan, Yang Jia, Tianle Zhou, Yong Chen, Zhonghua Ling, Xiaohong Hu

Materials Science and Engineering: C 2017 Volume 70(Part 1) pp:287-295

Publication Date(Web):1 January 2017

DOI:10.1016/j.msec.2016.08.086

•Antibacterial alginate/chitosan hydrogel dressing integrated with gelatin microspheres was fabricated.•Drug loaded gelatin microspheres improved biodegradable and mechanical properties of the dressing.•The composite dressing showed antibacterial performance and bacterial growth inhibition effects.An antibacterial and biodegradable composite hydrogel dressing integrated with microspheres is developed for drug delivery and wound healing. The mechanism of gelation is attributed to the Schiff-base reaction between aldehyde and amino groups of oxidized alginate (OAlg) and carboxymethyl chitosan (CMCS). To enhance antibacterial and mechanical properties, tetracycline hydrochloride (TH) loaded gelatin microspheres (GMs) were fabricated by an emulsion cross-linking method, followed by integrating into the OAlg-CMCS hydrogel to produce a composite gel dressing. In vitro gelation time, swelling, degradation, compressive modulus and rheological properties of the gel dressing were investigated as the function of microsphere ratios. With increasing ratios of microspheres from 10 to 40 mg/mL, the composite dressing manifested shorter gelation time and lower swelling ratios, as well as higher mechanical strength. Comparing to other formulations, the gel dressing with 30 mg/mL microspheres showed more suitable stabilities and mechanical properties for wound healing. Also, in vitro drug release results showed that the loaded TH could be sustained release from the composite gel dressing by contrast with pure hydrogels and microspheres. Furthermore, powerful bacteria growth inhibition effects against Escherichia coli and Staphylococcus aureus suggested that the composite gel dressing, especially the one with 30 mg/mL GMs containing TH, has a promising future in treatment of bacterial infection.

Preparation of grafted cationic polymer/silver chloride modified cellulose fibers and their antibacterial properties

Co-reporter:Xiaoqin Chen;Bojian Hu;Zuliang Liu;Yan Zuo;Qian Xiang

Journal of Applied Polymer Science 2015 Volume 132( Issue 25) pp:

Publication Date(Web):

DOI:10.1002/app.42092

ABSTRACT

In this article, we present a simple method for synthesizing antibacterial cellulose fibers that were modified with a cationic polymer and immobilized silver chloride (AgCl) particles. Relatively simple techniques of graft polymerization and onsite precipitation were used to fabricate the composites. Scanning electron microscopy images, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and energy-dispersive X-ray spectroscopy confirmed the immobilization of the AgCl particles. The observed inhibition zone of the immobilized AgCl particle composites indicated that the biocidal silver ions were released from the composites in aqueous solution. Compared with cationic-polymer-grafted cellulose fibers or AgCl alone, the cationic polymer/AgCl composites showed excellent antibacterial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42092.

Preparation, characterization, and antibacterial activities of quaternarized N-halamine-grafted cellulose fibers

Co-reporter:Xiaoqin Chen;Zuliang Liu;Weiwei Cao;Chunyan Yong

Journal of Applied Polymer Science 2015 Volume 132( Issue 43) pp:

Publication Date(Web):

DOI:10.1002/app.42702

ABSTRACT

A viable method for coating of cellulose fiber with quaternarized N-halamine is reported in this article. The use of quaternary ammonium salt group in combination with N-halamine group can reinforce the antibacterial activity. The chemical structure of as-synthesized N-halamine precursor 4-(Bromo-acetic acid methylester)-4-ethyl-2- oxazolidinone (BEO) was characterized by ¹H-NMR. The cellulose fibers were characterized by Fourier transform infrared spectra and X-ray photoelectron spectra. The spectra data confirmed that the quaternarized N-halamine-grafted cellulose fibers were successfully obtained. The antibacterial properties of functional fibers were challenged with both Gram positive and Gram negative bacteria. The antibacterial tests and showed that the as-prepared antibacterial cellulose fibers exhibited powerful and rapid bactericidal performance against both Gram negative E. coli and Gram positive S. aureus. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42702.

Dual action bactericides: Quaternary ammonium/N-halamine-functionalized cellulose fiber

Co-reporter:Bojian Hu;Xiaoqin Chen;Yan Zuo;Zuliang Liu

Journal of Applied Polymer Science 2014 Volume 131( Issue 7) pp:

Publication Date(Web):

DOI:10.1002/app.40070

ABSTRACT

Bi-functional antibacterial material was prepared by co-grafting N-halamine and quaternary ammonium salt monomers from cellulose fiber. The grafted fiber was characterized by Fourier transform infrared spectra, and X-ray photoelectron spectra. The N-halamine derived from the precursor 4-[(acryloxy)methyl]-4-ethyl-2-oxazolidinone via chlorination treatment and the oxidative chlorine (Cl⁺) leaching behavior were investigated. The antibacterial activities of singly (only QAs-functionalized or only Cl⁺-releasing) and dual (QAs-functionalized and Cl⁺-releasing) functional cellulose fibers were tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Compared to singly functionalized formulations, the bi-functional cellulose fiber exhibited excellent and rapid bactericidal performance against both E. coli and S. aureus. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40070.