An efficient mechanically activated solvent-free synthesis of 1,3,5-triaryl-2-pyrazolines from chalcones and phenylhydrazines using high speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time and neat conditions.

A Yb(OTf)3-catalyzed approach for the synthesis of pyrroles under solvent-free conditions was achieved, which could afford the desired products with yields ranged from moderate to excellent.

Despite its biological importance, little is known about the solubility properties of tiamulin hydrogen fumarate in different solvents. This work presents solubility of tiamulin hydrogen fumarate in acetone, acetonitrile, ethyl acetate, ethyl formate, and butyl acetate from (288.2 to 318.2) K at atmospheric pressure. The solubility data have been correlated by the Apelblat equation.

Catalyzed by ytterbium(III) triflate hydrate [Yb(OTf)3·xH2O], the Michael addition and cyclocondensation of α,β-unsaturated ketones with active methylene compounds to afford the 1,4-adducts and benzo[b]pyran derivatives, respectively were studied.

2,3-Dihydroquinazolin-4(1H)-ones have been synthesized in high to excellent yields through direct cyclocondensation of anthranilamides and aldehydes in ionic liquids (ILs) or one-pot three-component cyclocondensation of isatoic anhydrides, ammonium acetate and aldehydes in ionic liquid–water solvent system without the use of any additional catalyst.

2,3-Dihydro-2-aryl-4(1H)-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc(OTf)3 under mild conditions.

Clean thiolysis reaction of various epoxides in ionic liquids (ILs) without the use of any catalyst generates β-hydroxy sulfides in excellent yields (83–98%) with high regioselectivity and chemoselectivity under mild reaction conditions.