Co-reporter:Lin Guo, Ji Huang, Xin Zhang, Ying Li and Limin Zheng
Journal of Materials Chemistry A 2008 vol. 18(Issue 48) pp:5993-5997
Publication Date(Web):13 Nov 2008
DOI:10.1039/B808556K
Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.
Co-reporter:Lin Guo, Zhongkui Wu and Yingqiu Liang
Chemical Communications 2004 (Issue 14) pp:1664-1665
Publication Date(Web):11 Jun 2004
DOI:10.1039/B403870C
Different sizes of nanotubes of poly(2-methoxy-5-(n-hexadecyloxy)-p-phenylene vinylene)
(MH-PPV) have been fabricated at the air/water interface by compressing a monolayer of MH-PPV beyond its collapse point, and their structural characteristics were studied by means of TEM, AFM, SAXRD, IRRAS.
Co-reporter:Lin Guo, Ji Huang, Xin Zhang, Ying Li and Limin Zheng
Journal of Materials Chemistry A 2008 - vol. 18(Issue 48) pp:NaN5997-5997
Publication Date(Web):2008/11/13
DOI:10.1039/B808556K
Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.