Ming Ma

Name:

Organization: Hunan Normal University

Department: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering

Title:

Chemicals
References

New urea-modified paper substrate for enhanced analytical performance of negative ion mode paper spray mass spectrometry

Co-reporter:Jingjing Liu, Yan He, Shuo Chen, Ming Ma, Shouzuo Yao, Bo Chen

Talanta 2017 Volume 166() pp:306-314

Publication Date(Web):1 May 2017

DOI:10.1016/j.talanta.2017.01.076

•A novel urea-modified paper is developed for paper spray mass spectrometry (PS-MS).•Analytical performance of negative ion mode PS-MS is improved using this paper.•Ionization suppression due to anion and highly polar compound reduces during PS-MS.•Formation of Cl- adduct ion peak reduces in mass spectra significantly for PS-MS.Electrospray ionization mass spectrometry (ESI-MS) analysis in the negative ion mode is adversely affected by ionization suppression caused by electrical discharge and the presence of salts. Paper spray mass spectrometry (PS-MS) also suffers from the above phenomenon, being built on principles similar to those of ESI. Herein, we report the use of a paper substrate modified by 1-[3-(trimethoxysilyl)propyl]urea to improve the sensitivity of quantitative PS-MS analysis in the negative ion mode. The obtained results demonstrated that the urea modified paper substrate can effectively bind anions and highly polar compounds in the sample solution, decreasing competitive ionization in the negative ion mode of PS-MS and significantly reducing the signal intensity of Cl− adducts. In addition, the analyte responses were also significantly improved owing to the decreased electrical discharge observed for the less polar surface to decrease electrical discharge. Compared to non-modified PS-MS, urea-modified PS-MS exhibits a much higher sensitivity, showing 2−109 times improved signal-to-noise ratio (S/N). In real sample analysis, the limits of detection (LODs) of salicylic acid in urine and terpene lactones in Ginkgo biloba extract (EGb) were improved 10-fold and 2–40-fold, respectively, compared to that of non-modified PS-MS.

Three-dimensional graphene-like carbon frameworks as a new electrode material for electrochemical determination of small biomolecules

Co-reporter:Wenfang Deng, Xiaoyan Yuan, Yueming Tan, Ming Ma, Qingji Xie

Biosensors and Bioelectronics 2016 Volume 85() pp:618-624

Publication Date(Web):15 November 2016

DOI:10.1016/j.bios.2016.05.065

•Novel three-dimensional graphene-like carbon frameworks (3DGLCFs) were prepared.•The 3DGLCFs possess graphene-like network structure and high specific surface area.•The 3DGLCFs outperform commercial graphene for detecting small biomolecules.•Ultra-low detection limits are obtained for detecting ascorbic acid, dopamine and uric acid.Three-dimensional (3D) graphene-like carbon frameworks (3DGLCFs) were facilely prepared via copyrolysis of polyaniline and nickel nitrate powder, followed by acid etching. The as-prepared 3DGLCFs possess graphene-like network structure, high specific surface area, and high content nitrogen dopant. Because these features enable large electrochemically active surface area, rapid electron transfer, and fast transport of analytes to electrode surface, the 3DGLCFs modified glassy carbon electrode (GCE) shows current response much higher than commercial graphene (CG) modified GCE towards the oxidation of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The anodic peak separations at 3DGLCFs/GCE are 0.23 V between AA and DA, 0.13 V between DA and UA, and 0.36 V between AA and UA. For the simultaneous electrochemical determination of AA, DA and UA using differential pulse voltammetry, the 3DGLCFs/GCE shows linear response ranges of 1.25×10−5–4×10−4 M for AA, 5×10−8–1.0×10−5 M for DA, and 5×10−8–1.5×10−5 M for UA, with low detection limits of 2×10−6 M for AA, 1×10−8 M for DA, and 1×10−8 M for UA. The 3DGLCFs/GCE was also applied for the measurement of human serum, exhibiting satisfactory recoveries.

Three-dimensional activated graphene network–sulfonate-terminated polymer nanocomposite as a new electrode material for the sensitive determination of dopamine and heavy metal ions

Co-reporter:Xiaoyan Yuan, Yijia Zhang, Lu Yang, Wenfang Deng, Yueming Tan, Ming Ma and Qingji Xie

Analyst 2015 vol. 140(Issue 5) pp:1647-1654

Publication Date(Web):12 Jan 2015

DOI:10.1039/C4AN02263G

We report here that three-dimensional activated graphene networks (3DAGNs) are a better matrix to prepare graphene–polymer nanocomposites for sensitive electroanalysis than two-dimensional graphene nanosheets (2DGNs). 3DAGNs were synthesized in advance by the direct carbonization and simultaneous chemical activation of a cobalt ion-impregnated D113-type ion exchange resin, which showed an interconnected network structure and a large specific surface area. Then, the 3DAGN–sulfonate-terminated polymer (STP) nanocomposite was prepared via the in situ chemical co-polymerization of m-aminobenzene sulfonic acid and aniline in the presence of 3DAGNs. The 3DAGN–STP nanocomposite can adsorb dopamine (DA) and heavy metal ions, which was confirmed by quartz crystal microbalance studies. The 3DAGN–STP modified glassy carbon electrode (GCE) was used for the electrochemical detection of DA in the presence of ascorbic acid and uric acid, with a linear response range of 0.1–32 μM and a limit of detection of 10 nM. In addition, differential pulse voltammetry was used for the simultaneous determination of Cd2+ and Pb2+ at the 3DAGN–STP/GCE further modified with a bismuth film, exhibiting linear response ranges of 1–70 μg L−1 for Cd2+ and 1–80 μg L−1 for Pb2+ with limits of detection of 0.1 μg L−1 for Cd2+ and 0.2 μg L−1 for Pb2+. Because the 3DAGN–STP can integrate the advantages of 3DAGNs with STPs, the 3DAGN–STP/GCE was more sensitive than the bare GCE, 3DAGN/GCE, and 2DGN–STP/GCE for the determination of DA and heavy metal ions.

Determination of catecholamines in urine using aminophenylboronic acid functionalized magnetic nanoparticles extraction followed by high-performance liquid chromatography and electrochemical detection

Co-reporter:Liwei Jiang;Yibang Chen;Yanmei Luo;Yueming Tan;Bo Chen;Qingji Xie;Xubiao Luo

Journal of Separation Science 2015 Volume 38( Issue 3) pp:460-467

Publication Date(Web):

DOI:10.1002/jssc.201400920

A new method was developed for the simultaneous determination of three catecholamines in urine using aminophenylboronic acid functionalized magnetic nanoparticles extraction followed by high-performance liquid chromatography with electrochemical detection. Novel aminophenylboronic acid functionalized magnetic nanoparticles were prepared by multi-step covalent modification, and characterized by transmission electron microscopy, Fourier-transformed infrared spectroscopy, X-ray diffraction, and vibrating sample magnetometry. With the help of the high affinity between the boronate and cis-diol group, the particles were used for the highly selective separation and enrichment of three major catecholamines, norepinephrine, epinephrine, and dopamine. Effects of the pH of the feed solution, the extraction time, the composition of the buffer solution, the amount of the magnetic particles, the elution conditions, and the recycling of aminophenylboronic acid functionalized magnetic nanoparticles were explored. Under the optimized conditions, 13–17-fold enrichment factors were obtained. The linear ranges were 0.01–2.0 μg/mL for the studied analytes. The limits of detection and quantification were in the range of 2.0–7.9 and 6.7–26.3 ng/mL, respectively. The relative recoveries were in the range of 92–108%, with intraday and interday relative standard deviations lower than 6.8%. This method was successfully applied to analysis of catecholamines in real urine.

A superhydrophobic poly(dimethylsiloxane)-TiO2 coated polyurethane sponge for selective absorption of oil from water

Co-reporter:Qian Shuai, Xiaotian Yang, Yanmei Luo, Hao Tang, Xubiao Luo, Yueming Tan, Ming Ma

Materials Chemistry and Physics 2015 Volume 162() pp:94-99

Publication Date(Web):15 July 2015

DOI:10.1016/j.matchemphys.2015.05.011

•TiO2 and poly(dimethylsiloxane) were used to prepare a superhydrophobic sponge.•Surface modifications can change hydrophobic properties and improve sorption selectivity.•Fast sorption speed, high sorption capacity, and outstanding recyclability were achieved.•The developed method is facile, low-cost, and does not require any intricate equipment.The development of promising superhydrophobic absorption materials for the treatment of oil spills and chemical leakage is significant to environmental protection. Herein, a novel superhydrophobic poly(dimethylsiloxane) (PDMS)-TiO2 coated polyurethane (PU) sponge was facilely fabricated by sol–gel growth of TiO2 nanoparticles on the surface of PU sponge, followed by in situ polymerization of PDMS. The as-prepared PDMS-TiO2-PU sponge shows a superhydrophobic surface with a water contact angle of 154° and exhibits high sorption capacities of more than 16.7 g g−1 for the studied oils and organic compounds, such as pump oil, diesel oil, silicone oil, edible oil, kerosene, dichloromethane, and chloroform. Fast sorption speed and high sorption selectivity are achieved for diesel oil sorption. The absorbed oil can be retrieved by simple mechanical extruding the sponge, and the recovered sponge can be used repeatedly over 60 times without obvious decrease in sorption capacity. These results suggest that the prepared PDMS-TiO2-PU sponge may be used in the cleanup of oil spills and the removal of organic pollutants from water.

Determination of monoamine neurotransmitters in human urine by carrier-mediated liquid-phase microextraction based on solidification of stripping phase

Co-reporter:Liwei Jiang, Yibang Chen, Yejun Chen, Ming Ma, Yueming Tan, Hao Tang, Bo Chen

Talanta 2015 Volume 144() pp:356-362

Publication Date(Web):1 November 2015

DOI:10.1016/j.talanta.2015.06.068

•Simultaneous extraction of hydrophilic analytes with a mixed carrier was achieved.•Solidifying the aqueous stripping phase in the back-extraction process was developed.•The established method is selective, accurate and sensitive.A novel method was developed for the analysis of monoamine neurotransmitters (MNTs) in human urine by carrier-mediated liquid-phase microextraction based on solidification of stripping phase method (CM-LPME-SSP) coupled with high performance liquid chromatography-electrochemical detector (HPLC-ECD). By adding an appropriate carrier in organic phase, simultaneous extraction of hydrophilic analytes, MNTs, with high enrichment factors (22.6–36.1 folds) and excellent sample cleanup was achieved. A new strategy, solidifying the aqueous stripping phase in the back-extraction process, was developed to facilitate the collection of the stripping phase as small as a few microliters. Combined with HPLC-ECD analysis, the linear ranges of the established method were 0.015–2.0 μg/mL for NE, E, DA, and 0.020–2.0 μg/mL for 5-HT. The limits of detection and quantification were in the range of 5.5–10.8 ng/mL and 15–20 ng/mL, respectively. The relative recoveries were in the range of 87–108%, with intraday and interday relative standard deviations lower than 13%. This method was successfully applied to analysis of MNTs in real urine.

A study on separation and extraction of four main alkaloids in Macleaya cordata (Willd) R. Br. with strip dispersion hybrid liquid membrane

Co-reporter:Li Ouyang;Xiaoli Su;Dingsheng He;Yuanyuan Chen;Qingji Xie ;Shouzhuo Yao

Journal of Separation Science 2010 Volume 33( Issue 13) pp:2026-2034

Publication Date(Web):

DOI:10.1002/jssc.201000103

Abstract

A technique based on strip dispersion hybrid liquid membrane was developed for the separation and extraction of four main alkaloids from fruits of Macleaya cordata (Willd) R. Br. A microporous polypropylene membrane impregnated with an organic membrane solution comprised the heart of the strip dispersion hybrid liquid membrane system. The membrane solution was made by dissolving a cationic carrier, di-(2-ethylhexyl) phosphoric acid in an inexpensive, less toxic membrane solvent, kerosene. The transport of alkaloids from an aqueous feed solution through the membrane to a strip dispersion phase was driven by the concentration gradient of H⁺ and facilitated by di-(2-ethylhexyl) phosphoric acid. The effects of the extraction time and reuse times of the membrane, the strip solution composition, the carrier concentration, the volume ratio of the aqueous strip solution to the organic membrane solution, and the flow rates of the feed solution and the strip dispersion phase on the transport of alkaloids were investigated. Under the optimal conditions, the permeability coefficients obtained for the four main alkaloids allocryptopine, protopine, sanguinarine, and chelerythrine were 1.66, 1.99, 2.98, and 3.06×10⁻⁴ cm/s, and the transport efficiencies were as high as 68, 77, 83, and 85%, respectively.

Extraction and preconcentration of β-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction

Co-reporter:Li Zhang, Xiaoli Su, Chenggong Zhang, Li Ouyang, Qingji Xie, Ming Ma, Shouzhuo Yao

Talanta 2010 Volume 82(Issue 3) pp:984-992

Publication Date(Web):15 August 2010

DOI:10.1016/j.talanta.2010.06.003

A novel method was developed for the analysis of four β-blockers, namely sotalol, carteolol, bisoprolol, and propranolol, in human urine by coupling carrier-mediated liquid phase microextraction (CM-LPME) to high performance liquid chromatography (HPLC). By adding an appropriate carrier in organic phase, simultaneous extraction and enrichment of hydrophilic (sotalol, carteolol, and bisoprolol) and hydrophobic (propranolol) drugs were achieved. High enrichment factors were obtained by optimizing the compositions of the organic phase, the acceptor solution, the donor solution, the stirring rate, and the extraction time. The linear ranges were from 0.05 to 10.0 mg L−1 for sotalol and carteolol, and from 0.05 to 8.0 mg L−1 for bisoprolol and propranolol. The limits of detection (S/N = 3) were 0.01 mg L−1 for sotalol, carteolol, and bisoprolol, and 0.005 mg L−1 for propranolol. The relative standard deviations were lower than 6%. The developed method exhibited high analyte preconcentration and excellent sample clean-up effects with little solvent consumption and was found to be sensitive and suitable for simultaneous determination of the above four drugs spiked in human urine. Furthermore, the successful analysis of propranolol in real urine specimens revealed that the determination of β-blockers in human urine is feasible using the present method.

Carrier-mediated liquid phase microextraction coupled with high performance liquid chromatography for determination of illicit drugs in human urine

Co-reporter:Zhaohui Zhang, Chenggong Zhang, Xiaoli Su, Ming Ma, Bo Chen, Shouzhuo Yao

Analytica Chimica Acta 2008 Volume 621(Issue 2) pp:185-192

Publication Date(Web):28 July 2008

DOI:10.1016/j.aca.2008.05.016

A new method was developed for the analysis of illicit drugs in human urine by coupling carrier-mediated liquid phase microextraction (LPME) to high performance liquid chromatography (HPLC). By adding an appropriate carrier in organic phase, simultaneous extraction and enrichment of hydrophilic (morphine and ephedrine) and hydrophobic (pethidine) drugs were achieved. Effects of the types of organic solvents and carriers, the carrier concentration in the organic phase, the HCl concentration in the acceptor solution, the stirring rate, and the extraction time on the enrichment factor of analytes were investigated. Under the optimal experimental conditions, high enrichment factors (202–515) were obtained. The linear detection ranges were 0.1–10 mg L−1 for the studied drugs. The limits of detection (LOD) at signal-to-noise ratio of 3 were 0.05 mg L−1 for both morphine and ephedrine, and 0.02 mg L−1 for pethidine. This method was successfully applied to analysis of ephedrine in real urine specimens, revealing that the determination of illicit drugs in urine was feasible.

Simultaneous determination of water-soluble and fat-soluble synthetic colorants in foodstuff by high-performance liquid chromatography–diode array detection–electrospray mass spectrometry

Co-reporter:Ming Ma, Xubiao Luo, Bo Chen, Shengpei Su, Shouzhuo Yao

Journal of Chromatography A 2006 Volume 1103(Issue 1) pp:170-176

Publication Date(Web):20 January 2006

DOI:10.1016/j.chroma.2005.11.061

An accurate method was developed for the simultaneous determination of water-Tartrazine, Amaranth, Ponceau 4R, Sunset Yellow FCF, and fat-Sudan (I–IV), synthetic soluble colorants in foodstuff. This method uses dimethylsulfoxide (DMSO) as the extraction solvent in the sample preparation process and high performance liquid chromatography (HPLC)–diode array detector (DAD)–electrospray mass spectrometry (ESI-MS), applying selected ion recording in positive/negative alternate mode to acquire mass spectral data, as the analytical technique. Linearity of around three orders in the magnitude of concentration was generally obtained. Detection and quantification limits of the investigated dyes, which were evaluated at signal to noise ratio of 3 for detection limit and 10 for quantification limit, were in the ranges of 0.01–4 and 0.03–11.2 ng, respectively. The recoveries of the eight synthetic colorants in four matrices ranged from 93.2 to 108.3%. Relative standard deviations of less than 8.2% were also achieved. This method has been applied successfully in the determination of water-soluble colorants in the soft drink and the delicious ginger, and fat-soluble dyes in chilli powders and chilli spices.

Three-dimensional nitrogen-doped graphene derived from poly-o-phenylenediamine for high-performance supercapacitors

Co-reporter:Wenfang Deng, Youming Zhang, Yueming Tan, Ming Ma

Journal of Electroanalytical Chemistry (15 February 2017) Volume 787() pp:

Publication Date(Web):15 February 2017

DOI:10.1016/j.jelechem.2017.01.047

•Three-dimensional nitrogen-doped graphene (3DNGN) were prepared from poly-o-phenylenediamine with the aid of Ni(NO3)2.•The 3DNGN possesses high graphitization degree, large specific surface area, and high content of nitrogen doping.•The 3DNGN shows specific capacitance, rate capability, energy density, and power density superior to commercial graphene.•The 3DNGN shows a specific capacitance in acidic electrolyte higher than that in alkaline electrolyte.We report here that poly-o-phenylenediamine as a solid carbon source can be facilely carbonized to produce three-dimensional nitrogen-doped graphene (3DNGN) with the aid of Ni(NO3)2 powder. In situ formed Ni nanoparticles by decomposition of Ni(NO3)2 serve as both template and catalyst for the formation of 3DNGN. The 3DNGN with interconnected porous structure and high content of nitrogen doping can ensure large electrolyte-accessible surface area, rapid ion transportation, and fast electron transport, resulting in high electrochemical performance. The 3DNGN shows a high specific capacitance of 312 F g− 1 at 1 A g− 1 with good capacitance retention capability and good cycling stability, and outputs a high average energy power density of 10.8 W h kg− 1 and a high maximum power density of 595 kW kg− 1 in aqueous KOH electrolyte. Due to the great pseudocapacitance in aqueous H2SO4 electrolyte, the specific capacitance of the 3DNGN can reach a high value of 345 F g− 1 at 1 A g− 1.