An enantioresolution of 2-methoxy-2-(1-naphtyl)propionic acid (MαNP acid) using the diastereomeric salt with chiral (R)-phenylethylamine was achieved to give enantiopure (R)-MαNP acid in 29% yield with >99% ee based on rac-MαNP acid. X-ray crystallographic analysis of diastereomeric salt revealed that (R)-MαNP acid was tightly arranged by four independent hydrogen bonds and one CH–π interaction with (R)-phenylethylamine.

An enantioresolution of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl oxide (BINAPO) into its enantiomers was achieved using the inclusion complex with a commerciallyavailable chiral 2,2′-dihydroxy-1,1′-binaphthyl ((R)-BINOL), giving the two enantiomers with 99% ee and 72% ee, respectively.

The reductive coupling of aromatic N,N-acetals and N,O-acetal activated by chlorotrimethylsilane proceeded smoothly in the presence of zinc to give the corresponding diamines in good yields.The reductive coupling of aromatic N,N-acetals and N,O-acetal activated by chlorotrimethylsilane proceeded smoothly in the presence of zinc to give the corresponding diamines in good yields.

We have achieved an efficient synthesis of 1,1-dimethyl-3-(trifluoromethyl)-1H-isoindole N-oxide (2) in 39% yield by seven steps from 2-bromobenzoic acid (3). This compound serves as a spin trap reagent, giving a strong and stable ESR signal of the radical adduct of 2 in the presence of i-amyloxy radical generated by UV photolysis of i-amyl nitrite.We have achieved an efficient synthesis of spin trap reagent bearing trifluoromethyl group, 1,1-dimethyl-3-(trifluoromethyl)-1H-isoindole N-oxide (2), by seven steps from 2-bromobenzoic acid (3). A strong and stable ESR signal of the radical adduct of 2 was observed in the presence of i-amyloxy radical generated by UV photolysis of i-amyl nitrite.