A simple and efficient catalytic method for the synthesis of alkenyl halides via direct coupling of alcohols and alkynes using aqueous HX (X=Cl, Br) as halide sources has been developed under mild conditions in the presence of Fe powder (1 mol %). In comparison with the high loading of FeX3 in previously reported protocols, the present approach provides a remarkable attractive methodology to a diverse range of alkenyl halides due to the advantages of simple operation and low-level metal contamination.A simple and efficient catalytic method for the synthesis of alkenyl halides via direct coupling of alcohols and alkynes using aqueous HX (X=Cl, Br) as halide sources has been developed under mild conditions in the presence of Fe powder (1 mol %).

A novel and convenient method for the synthesis of fluoroalkenes from alkynes, alcohols and fluoroboric acid has been developed under mild conditions. The present protocol provides an attractive approach to access various fluoroalkenes from simple and commercially available starting materials without any metal catalyst, ligand or additive.A novel and convenient method for the synthesis of fluoroalkenes from simple starting materials has been developed under mild and metal-free conditions.

A novel and efficient copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen has been developed under mild and neat conditions. 18O labeling experiments revealed that both oxygen atoms of the α-ketoamides derived from molecular oxygen.

The first transition-metal-catalyzed direct oxidative synthesis of amides by using dioxygen as an oxygen source has been developed under mild conditions, in which DBU was used as the key additive. The present methodology, which utilizes dioxygen as an oxidant and oxygen source and cheap copper salts as catalysts, opens up an interesting and attractive avenue for the synthesis of amide functionality.

A new and efficient method for the synthesis of alkenyl iodides through direct coupling of alcohols and alkynes has been developed in the presence of iron powder, I2, and NaI. This methodology not only provides an attractive approach to alkenyl iodides, but also expands the application of iron in synthetic chemistry.A new and efficient method for the synthesis of alkenyl iodides through direct coupling of alcohols and alkynes has been developed in the presence of iron powder, I2, and NaI. This methodology not only provides an attractive approach to alkenyl iodides, but also expands the application of iron in synthetic chemistry.

The first copper-catalyzed direct three-component coupling reaction of aldehydes, alkynes, and hydroxylamines for the synthesis of propargylamines has been developed under mild conditions, which has the advantages of ready availability of catalyst as well as operation simplicity. The present protocol provides an appealing alternative for the construction of propargylamines in a simple and one-pot procedure.The first copper-catalyzed direct three-component coupling reaction of aldehydes, alkynes, and hydroxylamines for the synthesis of propargylamines has been developed in a simple and one-pot procedure.

A simple and efficient method for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via an indium(III)-catalyzed tandem reaction of α-ketoesters with primary or secondary aromatic amines. With respect to the reactions of pyruvates with amines, indium triflate (1 mol %) demonstrated superior catalytic activity and efficiency compared with previously reported AuCl3/AgSbF6 (5 mol %/15 mol %) cocatalyst. The reactions of α-alkyl substituted ketoesters and arylamines, which could not be effectively accomplished by the previous AuCl3/AgSbF6 and HNO3 catalytic systems proceeded smoothly in the presence of 10 mol % In(OTf)3 to afford the desired products in moderate to good yields (43%–91%).Keywords: aromatic amine; catalytic synthesis; indium triflate; ketoester; polysubstituted dihydroquinoline;

A simple and convenient Brønsted acid (HNO3)-catalyzed tandem reaction of α-ketoesters with primary or secondary aromatic amines for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via a tandem process, which has the advantages of ready availability of catalyst, operation simplicity, atom efficiency as well as low toxicity. In particular, tricyclic dihydroquinolines, generally prepared with multi-processes, could also be constructed in this one-pot procedure.A simple and convenient Brønsted acid (HNO3)-catalyzed tandem reaction of α-ketoesters with primary or secondary aromatic amines for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via a tandem process.

An efficient and facile gold-catalyzed three-component tandem process for the assembly of two types of highly functionalized butenolides has been developed. In this reaction system, more than four chemical bonds are formed by a single gold catalyst. The present tandem protocol includes a direct coupling of alkynes, amines, and glyoxylic acid and subsequent exclusively endo-selective cycloisomerization of alkynoic acids along with intermolecular electrophilic trapping; it utilizes three simple and commercially available starting materials to assemble architecturally complex and appealing butenolide scaffolds bearing other reactive sites for further manipulation.

A novel and efficient copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen has been developed under mild and neat conditions. 18O labeling experiments revealed that both oxygen atoms of the α-ketoamides derived from molecular oxygen.

The first transition-metal-catalyzed direct oxidative synthesis of amides by using dioxygen as an oxygen source has been developed under mild conditions, in which DBU was used as the key additive. The present methodology, which utilizes dioxygen as an oxidant and oxygen source and cheap copper salts as catalysts, opens up an interesting and attractive avenue for the synthesis of amide functionality.