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Hideki Abe

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Organization: Tokyo University of Pharmacy and Life Sciences
Department: School of Life Sciences
Title:
Directed synthesis of 2-spiroindolines from indole derivatives by formic acid-induced N-acyliminium ion-conjugated diene spirocyclization
Co-reporter:Hideki Abe, Naohiro Miyagawa, Sho Hasegawa, Toyoharu Kobayashi, Sakae Aoyagi, Chihiro Kibayashi, Tadashi Katoh, Hisanaka Ito
Tetrahedron Letters 2015 Volume 56(Issue 7) pp:921-924
Publication Date(Web):11 February 2015
DOI:10.1016/j.tetlet.2014.12.130
Synthesis of 2-spiroindolines from 2-substituted indole derivatives via acid-induced N-acyliminium ion-conjugated diene spirocyclization was demonstrated. This methodology can be used to direct transformations of 2-substituted indole moieties into 3-nonsubstituted-2-spiroindoline skeletons.
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