Co-reporter:Chunsong Xie, Deyu Han, Yue Hu, Jinhua Liu, Tian Xie
Tetrahedron Letters 2010 Volume 51(Issue 40) pp:5238-5241
Publication Date(Web):6 October 2010
DOI:10.1016/j.tetlet.2010.07.108
A novel and efficient synthesis of pyrrolidin-2-ones through the tandem reactions of vinyl sulfonium salts with malonyl amides under very mild conditions is reported. The reaction demonstrates a wide tolerance toward various aryls, acyl, sulfonyl, and benzyl while aliphatic groups delivering the tetrahydro-2-oxofuran product.