Geng-Xiu Zheng

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Name: 郑庚修

Organization: University of Jinan , China

Department: School of Chemistry and Chemical Engineering

Title: NULL(PhD)

TOPICS

Organic Chemistry

Chemicals
References

Redox active molybdophosphate produced by Cu3(PO4)2 nanospheres for enhancing enzyme-free electrochemical immunoassay of C-reactive protein

Co-reporter:Xiaofeng Tan;Lianhua Zhang;Xiaobo Deng;Luyang Miao;He Li;Gengxiu zheng

New Journal of Chemistry (1998-Present) 2017 vol. 41(Issue 20) pp:11867-11871

Publication Date(Web):2017/10/09

DOI:10.1039/C7NJ02629C

A sandwich electrochemical immunosensor for sensitive detection of C-reactive protein (CRP) was fabricated using Cu3(PO4)2 nanospheres-induced electrochemical current. Notably, signal generation was derived from the reaction of Cu3(PO4)2 nanospheres with adscititious molybdate ions. It would form a type of redox-active molybdophosphate precipitate on the electrodes, which could facilitate the generation of a stable and direct electrochemical current. In particular, it needs to be mentioned that +0.14 V was taken as the working potential for the electrochemical immunoassay, which could reduce the possible interference of the dissolved oxygen in the electrolyte. This would be reasonably helpful for the sensitive assay of CRP. Thanks to the abundant phosphate groups in Cu3(PO4)2 nanospheres, the detection signal could be enhanced sharply. As a result, the optimized enzyme-free electrochemical immunosensor presents an ultrasensitive detection performance toward CRP with a linear range from 0.5 pg mL−1 to 1 ng mL−1 and a low detection limit of 0.13 pg mL−1. The selectivity, reproducibility and stability of the immunosensor were tested and observed to be satisfactory. In general, the proposed analytical system shows promising potential for clinical diagnosis.

Catalyst-free synthesis of 3-sulfone nitrile from sulfonyl hydrazides and acrylonitrile in water

Co-reporter:Wei Li;Lingfeng Gao;Wenyun Zhuge;Xu Sun;Gengxiu Zheng

Organic & Biomolecular Chemistry 2017 vol. 15(Issue 37) pp:7819-7823

Publication Date(Web):2017/09/26

DOI:10.1039/C7OB01558E

A novel catalyst-free sulfonation reaction for synthesizing 3-sulfone nitrile compounds from sulfonyl hydrazides and acrylonitriles in water, without any metal catalyst, ligand or organic solvent, was demonstrated. This catalyst-free protocol provides a new synthetic method for the construction of 3-sulfone nitrile compounds with excellent yields. The D2O experiment adequately proved that the catalyst-free sulfonation reaction occurs via a Michael addition mechanism and that the hydrogen of 3-sulfone nitrile comes from water.

Study of highly efficient heterodinuclear Ir-Os ECL complexes

Co-reporter:Wei Sun, Shiguo Sun, Na Jiang, Lingfeng Gao, Gengxiu Zheng

Journal of Organometallic Chemistry 2017 Volume 846(Volume 846) pp:

Publication Date(Web):1 October 2017

DOI:10.1016/j.jorganchem.2017.07.014

•A series of heterodinuclear Ir-Os complexes through a flexible saturated carbon chain have been successfully synthesized.•The ECL spectra Ir-Os complexes exhibited perfect dual emission of green and red.•The ECL intensity of Osmium is about 2.2 times large than the corresponding mononuclear molecules.•First got the linear relationship of ECL intensity of Osmium moiety with the scanning potential.Among the heterodinuclear Ir-Os complexes, utilized concerted intra- and intermolecular interaction ECL, synchronously, the ECL efficiencies and emission energies of Osmium improved about 2.2 times. Furthermore, a good linear calibration curve between the ECL of Osmium intensity and the scanning potential were first gotten over the potential range from 0.70 V to 1.20 V and 1.20 V to 1.50 V, respectively.Download high-res image (169KB)Download full-size image

Reduced graphene oxide-supported Cu nanoparticles for the selective oxidation of benzyl alcohol to aldehyde with molecular oxygen

Co-reporter:Xue Feng, Panpan Lv, Wei Sun, Xinyu Han, Lingfeng Gao, Gengxiu Zheng

Catalysis Communications 2017 Volume 99(Volume 99) pp:

Publication Date(Web):1 August 2017

DOI:10.1016/j.catcom.2017.05.013

•The catalyst (Cu@rGO) was synthesized by a one-step reduction and characterized.•Cu@rGO was used for oxidation of benzyl alcohol in water.•Cu@rGO was applied in oxidation of other substituted-benzyl alcohols.•Cu@rGO could be easily separated and reused for several times.Copper nanoparticles supported on reduced graphene oxide (Cu@rGO) were prepared at room temperature via one-step reduction of graphene oxide and copper ions. Analyses by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) confirmed that copper was successfully decorated over the rGO sheets. The Cu@rGO nanocomposite can be used as an efficient heterogeneous catalyst in selective oxidation of benzyl alcohol to benzaldehyde with 97% conversion and 98% selectivity. The synergistic effect between copper nanoparticles and graphene results in a highly active and stable catalyst for several cycles of use.Download high-res image (66KB)Download full-size image

Correction: Quickly FeCl3-catalyzed highly chemo- and stereo-selective [3 + 2] dipolar cycloaddition of aziridines with isothiocyanates

Co-reporter:Lingfeng Gao, Kai Fu and Gengxiu Zheng

RSC Advances 2016 vol. 6(Issue 57) pp:52249-52249

Publication Date(Web):31 May 2016

DOI:10.1039/C6RA90049F

Correction for ‘Quickly FeCl3-catalyzed highly chemo- and stereo-selective [3 + 2] dipolar cycloaddition of aziridines with isothiocyanates’ by Lingfeng Gao et al., RSC Adv., 2016, 6, 47192–47195.

Quickly FeCl3-catalyzed highly chemo- and stereo-selective [3 + 2] dipolar cycloaddition of aziridines with isothiocyanates

Co-reporter:Lingfeng Gao, Kai Fu and Gengxiu Zheng

RSC Advances 2016 vol. 6(Issue 53) pp:47192-47195

Publication Date(Web):27 Apr 2016

DOI:10.1039/C6RA04923K

A FeCl3-catalyzed [3 + 2] cycloaddition reaction of aziridine with isothiocyanate was developed. The cycloaddition reaction was completed in two minutes with high chemoselectivity, stereoselectivity. 15 (tosylthiazolidin-2-ylidene)anilines were obtained with moderate to excellent yields.

A ratiometric fluorescence probe for detection of hydrogen sulfide in cells

Co-reporter:Bin Wang, Na Jiang, Wei Sun, Qiufen Wang and Gengxiu Zheng

RSC Advances 2016 vol. 6(Issue 43) pp:36906-36909

Publication Date(Web):30 Mar 2016

DOI:10.1039/C6RA02579J

A near-infrared ratiometric fluorescence probe for detection of H2S has been designed, synthesized and evaluated. The probe features high selectivity and sensitivity. Confocal microscopy imaging experiments demonstrate that the probe has potential as a powerful tool for the imaging of H2S in living cells.

Concise Synthesis of Key Intermediate of Mirabegron via a Mixed Anhydride Method

Co-reporter:Qi-Long Zhang, Zhi-Yuan Zhuang, Qing-Dong Liu, Zhan-Ming Zhang, Fu-Xu Zhan, and Geng-Xiu Zheng

Organic Process Research & Development 2016 Volume 20(Issue 11) pp:1993-1996

Publication Date(Web):October 13, 2016

DOI:10.1021/acs.oprd.6b00231

An efficiently scalable synthesis of key intermediate toward mirabegron has been developed via a mixed anhydride method, employing PivCl instead of EDCI and HOBt. The developed process produced (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide (10) in 91.5–92.3% yield and >99.0% HPLC purity under mild conditions. During this process, a side reaction induced by triethylamine hydrochloride was discovered and investigated, which was ultimately avoided by executing the reaction in a biphasic solvent system.Keywords: intermediate; mirabegron; mixed anhydride method; PivCl;

Construction of a turn-on probe for fast detection of H2S in living cells based on a novel H2S trap group with an electron rich dye

Co-reporter:Qian Yang, Fuxu Zhan, Qiufen Wang, Zhiyuan Zhuang, Guangyou Zhang and Gengxiu Zheng

RSC Advances 2015 vol. 5(Issue 128) pp:106156-106160

Publication Date(Web):10 Dec 2015

DOI:10.1039/C5RA21041K

A turn-on probe (ANR) for fast detection of H2S is constructed based on a 2-(azidomethyl)-4-nitrobenzoate moiety as a trap group. This group is very effective for the design of H2S probes especially with electron rich dyes. The potential biological applications of ANR were proved by employing it for fluorescence imaging of H2S in living cells.

A Three-Step Synthesis of Acotiamide for the Treatment of Patients with Functional Dyspepsia

Co-reporter:Kai Fu, Liu Yang, Qiu-Fen Wang, Fu-Xu Zhan, Bin Wang, Qian Yang, Zhi-Jia Ma, and Geng-Xiu Zheng

Organic Process Research & Development 2015 Volume 19(Issue 12) pp:2006-2011

Publication Date(Web):November 13, 2015

DOI:10.1021/acs.oprd.5b00256

A three-step synthesis of acotiamide is described. The agent is marketed in Japan for treatment of patients with functional dyspepsia. We designed a one-pot method to prepare the key intermediate 5a from 2 via an acyl chloride and amide and then reacted with 6 to obtain 1 under solvent-free condition. With the use of DCC, the unavoidable impurity 5b was also successfully converted into the desired 1. After isolation of 1, we carried forward to the next step of HCl salt formation, which was proved to be a very effective procedure for the removal of practically all major impurities. The process is cost-effective, simple to operate, and easy to scale-up.

An Improved Process for Preparation of S-Acetyl-l-glutathione

Co-reporter:Kai Fu, Qiu-Fen Wang, Fu-Xu Zhan, Liu Yang, Qian Yang, and Geng-Xiu Zheng

Organic Process Research & Development 2015 Volume 19(Issue 5) pp:590-593

Publication Date(Web):April 16, 2015

DOI:10.1021/acs.oprd.5b00081

An efficient one-step synthesis of S-acetyl-l-glutathione has been developed in a DMF–TFA mixed solvent with CoCl2 as catalyst. This process not only has the advantages of selective acylation of the glutathione thiol group without involving the free amino but also highlights recycling of the relatively costly solvent TFA, which improves the yield to 91% and quality to 99.7%. The reaction is cost-effective, efficient, and easy to scale-up.

Activation of Dioxygen by Cobaloxime and Nitric Oxide for Efficient TEMPO-Catalyzed Oxidation of Alcohols

Co-reporter:Yuanyuan Jing;Jun Jiang;Bo Yan;Shuai Lu;Jiemin Jiao;Huazhen Xue;Guanyu Yang;Gengxiu Zheng

Advanced Synthesis & Catalysis 2011 Volume 353( Issue 7) pp:1146-1152

Publication Date(Web):

DOI:10.1002/adsc.201100067

Abstract

The aerobic oxidation of alcohols to their corresponding carbonyl compounds could be efficiently accomplished by using the combination of cobalt nitrate, dimethylglyoxime and 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) as a novel catalytic system, and various alcohols including primary and secondary benzylic, allylic and aliphatic alcohols could be quantitatively converted to the corresponding aldehydes or ketones at 70 °C under 0.4 MPa dioxygen pressure in dichloromethane. During the oxidation, the in situ generated cobaloxime and nitric oxide (NO) were responsible for the activation of dioxygen, respectively, thereby, two concerted catalytic routes exist: cobaloxime-activating-dioxygen TEMPO-catalyzed and NO-activating-dioxygen TEMPO-catalyzed aerobic oxidation of alcohols.

Metal-Free: An Efficient and Selective Catalytic Aerobic Oxidation of Hydrocarbons with Oxime and N-Hydroxyphthalimide

Co-reporter:Gengxiu Zheng;Chunhong Liu;Qiufen Wang;Mingyu Wang;Guanyu Yang

Advanced Synthesis & Catalysis 2009 Volume 351( Issue 16) pp:2638-2642

Publication Date(Web):

DOI:10.1002/adsc.200900509

Abstract

A non-metal catalytic system consisting of dimethylglyoxime (DMG) and N-hydroxyphthalimide (NHPI) for the selective oxidation of hydrocarbons with dioxygen is described. The synergistic effect of DMG and NHPI ensures its efficient catalytic ability: 82.1% conversion of ethylbenzene with 94.9% selectivity for acetophenone could be obtained at 80 °C under 0.3 MPa of dioxygen in 10 h. Several hydrocarbons were efficiently oxidized to their corresponding oxygenated products under mild conditions.