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Jianping Liu

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Organization: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)
Department: School of Chemical Science and Technology
Title:
Total synthesis of lycorine-type alkaloids by cyclopropyl ring-opening rearrangement
Co-reporter:Dandan Liu, Long Ai, Fan Li, Annan Zhao, Jingbo Chen, Hongbin Zhang and Jianping Liu  
Organic & Biomolecular Chemistry 2014 vol. 12(Issue 20) pp:3191-3200
Publication Date(Web):11 Mar 2014
DOI:10.1039/C4OB00126E
A practical method for the synthesis of lycorine-type alkaloids with cis-B/C ring structure has been developed. Based on the reactions of aminocyclization, palladium-mediated arylation and especially cyclopropyl ring-opening rearrangement, the synthesis of anhydrocaranine, (±)-γ-lycorane and putative (±)-amarbellisine was accomplished.
One-pot synthesis of polyaniline doped with transition metal ions using H2O2 as oxidant
Co-reporter:Q. Huang;G. Chen;J. Liu
Polymers for Advanced Technologies 2014 Volume 25( Issue 12) pp:1391-1395
Publication Date(Web):
DOI:10.1002/pat.3365

Polyanilines (PANIs) doped with Zn2+ and Cu2+ were synthesized by H2O2 oxidative polymerization of aniline in the presence of corresponding metal chloride in solution. The products were characterized by elemental analysis, UV-Vis-NIR, FTIR and Raman spectroscopies. Scanning electron micrograph was employed to examine the morphology of PANIs fabricated in the presence of different transition metals. Experimental results showed that transition metal ions had been successfully incorporated into the polymer, and there was a strong interaction between the transition metal ions and the PANI chains. The electrical conductivity of PANI doped with Zn2+ and Cu2+ is 0.37 and 0.21 S/cm, respectively, which is higher than that of HCl doping PANI corresponding to 0.052 S/cm. The cyclic voltammetric study has indicated that incorporation of metal ions in PANI backbone results in increasing of specific capacitance compared to that of HCl doping PANI. Copyright © 2014 John Wiley & Sons, Ltd.

Synthesis and conformation studies of rubiyunnanin B analogs
Co-reporter:Na-Na Liu, Si-Meng Zhao, Jing-Feng Zhao, Guang-Zhi Zeng, Ning-Hua Tan, Jian-Ping Liu
Tetrahedron 2014 70(37) pp: 6630-6640
Publication Date(Web):
DOI:10.1016/j.tet.2014.06.108
Synthesis and cytotoxic activities of novel bergenin derivatives
Co-reporter:Na-Na Liu;Fu-Kai Bao;Jing-Bo Chen;Xiang-Hui Zeng
Medicinal Chemistry Research 2014 Volume 23( Issue 11) pp:4803-4813
Publication Date(Web):2014 November
DOI:10.1007/s00044-014-1050-9
A series of novel bergenin derivatives based on alcoholic hydroxyl group(s) modifications have been designed, synthesized and their cytotoxic activities against two human cancer cell lines including K562 and HL60 were evaluated. Over half of the tested derivatives, mainly with nitrogen containing moieties, displayed strong activities against K562 and HL60 cell lines.
Synthesis of the Putative Structure of (±)-Amarbellisine
Co-reporter:Dandan Liu, Jingbo Chen, Long Ai, Hongbin Zhang, and Jianping Liu
Organic Letters 2013 Volume 15(Issue 2) pp:410-413
Publication Date(Web):December 28, 2012
DOI:10.1021/ol3034093
The title compound was synthesized mainly by palladium catalytic coupling, cyclopropyl ring-opening rearrangement, epoxidation, Swern oxidation, demethanol reactions, and selective reduction. This synthesis was achieved in 16 steps with 9.7% overall yield. Unfortunately, the published spectroscopic data do not match with those of our synthetic compound.
Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives
Co-reporter:Rui Wang, Hong-Fan Shi, Jing-Feng Zhao, Yan-Ping He, Hong-Bin Zhang, Jian-Ping Liu
Bioorganic & Medicinal Chemistry Letters 2013 Volume 23(Issue 6) pp:1760-1762
Publication Date(Web):15 March 2013
DOI:10.1016/j.bmcl.2013.01.045
A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggest that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume of the molecule.
Total synthesis of lycorine-type alkaloids by cyclopropyl ring-opening rearrangement
Co-reporter:Dandan Liu, Long Ai, Fan Li, Annan Zhao, Jingbo Chen, Hongbin Zhang and Jianping Liu
Organic & Biomolecular Chemistry 2014 - vol. 12(Issue 20) pp:NaN3200-3200
Publication Date(Web):2014/03/11
DOI:10.1039/C4OB00126E
A practical method for the synthesis of lycorine-type alkaloids with cis-B/C ring structure has been developed. Based on the reactions of aminocyclization, palladium-mediated arylation and especially cyclopropyl ring-opening rearrangement, the synthesis of anhydrocaranine, (±)-γ-lycorane and putative (±)-amarbellisine was accomplished.
1,4-Cyclohexadiene-1-ethanamine, 4-methoxy-
1,4-Cyclohexadiene-1-ethanamine, 4-methoxy-
CAS:67175-79-5
1,4-Cyclohexadiene-1-ethanamine, 4-methoxy-
(3aS,12bR,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine
(3aS,12bR,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine
CAS:63814-03-9
(3aS,12bR,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine
4-(2-{[(6-bromo-1,3-benzodioxol-5-yl)methyl]amino}ethyl)phenol
4-(2-{[(6-bromo-1,3-benzodioxol-5-yl)methyl]amino}ethyl)phenol
CAS:34315-37-2
4-(2-{[(6-bromo-1,3-benzodioxol-5-yl)methyl]amino}ethyl)phenol
Lycorine
Lycorine
CAS:476-28-8
Lycorine
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-O-methyl-, methylester
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-O-methyl-, methylester
CAS:113850-71-8
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-O-methyl-, methylester
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-
CAS:112196-49-3
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-
L-Alanine, N-L-phenylalanyl-, methyl ester
L-Alanine, N-L-phenylalanyl-, methyl ester
CAS:80870-39-9
L-Alanine, N-L-phenylalanyl-, methyl ester
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-, methyl ester
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-, methyl ester
CAS:71257-76-6
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl-, methyl ester
L-ALANINE, N-L-TRYPTOPHYL-, METHYL ESTER
L-ALANINE, N-L-TRYPTOPHYL-, METHYL ESTER
CAS:63430-78-4
L-ALANINE, N-L-TRYPTOPHYL-, METHYL ESTER
Methyl 2-[[3-(1h-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoate
Methyl 2-[[3-(1h-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoate
CAS:63430-66-0
Methyl 2-[[3-(1h-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoate