Philipp Selig

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Organization: RWTH Aachen University
Department: Institute of Organic Chemistry
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Co-reporter:Philipp Selig and William Raven
Organic Letters 2014 Volume 16(Issue 19) pp:5192-5195
Publication Date(Web):September 12, 2014
DOI:10.1021/ol502554e
N-Protected o-aminobenzaldehydes smoothly react with α,γ-dialkylallenoates under Brønsted basic conditions to yield 2,3-disubstituted quinolines. This three-step reaction cascade of Michael addition, aldol condensation, and 1,3-N → C rearrangement uses the complete protecting group as a building block in a highly efficient C,C-bond formation of a new all-carbon quaternary center. Carbamate protected substrates (N-Boc, N-Cbz, N-Alloc) thus give 2-quinolin-2-yl-malonates, while amide protected substrates (N-Ac, N-Bz) afford 2-quinolin-2-yl-β-ketoesters in high yields.
Co-reporter:Philipp Selig, Aleksej Turočkin and William Raven  
Chemical Communications 2013 vol. 49(Issue 28) pp:2930-2932
Publication Date(Web):22 Feb 2013
DOI:10.1039/C3CC40855H
The first synthesis of highly substituted 3-alkyl-oxetan-2-ylidenes from allenoates was developed by using the bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as an exceptionally active nitrogen Lewis base catalyst.
Co-reporter:Philipp Selig;Aleksej Turo&x10d;kin;William Raven
Advanced Synthesis & Catalysis 2013 Volume 355( Issue 2-3) pp:297-302
Publication Date(Web):
DOI:10.1002/adsc.201200807

Abstract

The bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was discovered as an efficient catalyst for the reaction of γ-substituted allenoates with aromatic aldehydes. 4H-1,3-Dioxin-6-ylpropanoates with four newly formed bonds and four stereogenic centers were obtained in good yields and excellent diastereoselectivities by two consecutive Morita–Baylis–Hillman reactions, acetalization and intramolecular Michael addition. This four-step reaction cascade not only significantly expands the scope of catalytic allenoate functionalizations but also highlights the potential of TBD to act as a multifunctional Lewis base catalyst.

Co-reporter:Philipp Selig
Angewandte Chemie International Edition 2013 Volume 52( Issue 28) pp:7080-7082
Publication Date(Web):
DOI:10.1002/anie.201301282
Co-reporter:Philipp Selig
Angewandte Chemie 2013 Volume 125( Issue 28) pp:7218-7220
Publication Date(Web):
DOI:10.1002/ange.201301282
Co-reporter:Philipp Selig, Aleksej Turočkin and William Raven
Chemical Communications 2013 - vol. 49(Issue 28) pp:NaN2932-2932
Publication Date(Web):2013/02/22
DOI:10.1039/C3CC40855H
The first synthesis of highly substituted 3-alkyl-oxetan-2-ylidenes from allenoates was developed by using the bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as an exceptionally active nitrogen Lewis base catalyst.
Benzenepropanoic acid, α-1-propen-1-ylidene-, ethyl ester
Carbamic acid, [2-(hydroxymethyl)phenyl]-, 2-propenyl ester
3-[TERT-BUTYL(DIPHENYL)SILYL]OXYPROPAN-1-AMINE
benzyl2-formylphenylcarbamate
2,3-Hexadienoic acid, 2,5-dimethyl-, ethyl ester
2,3-Hexadienoic acid, 5,5-dimethyl-, ethyl ester
Benzenepropanoic acid, α-(triphenylphosphoranylidene)-, ethyl ester
N-(2-Formylphenyl)acetamide