The Schmidt reaction, the treatment with hydroazoic acid in the presence of a strong acid, converts ketones to amides directly and has been broadly applied in organic synthesis. In this communication, the Schmidt reaction of ketones was carried out in DME solution in a continuous-flow microreactor and gave the amide products. The enclosed small-volume feature of the microreactor made this reaction safe, fast, and cost-effective.

A lithium–halogen exchange reaction procedure was applied to introduce electrophilic substituents to the heteroaromatics, which exhibited potential in the syntheses of pharmaceutical intermediates. In this contribution, generation and reactions of heteroaromatic lithium compounds were successfully accomplished at 10 °C in a continuous flow microreactor equipped with an in-line mixer. Extensive reaction results revealed that such a synthetic method was widely applicable for different kinds of heteroaromatics with various substituents. All results highlighted that the lithium–halogen exchange reaction for large-scale syntheses might be realized by microreactor systems.

A simple and efficient method for the synthesis of 2,4,5-trisubstituted imidazoles has been developed by using a continuous flow microreactor system under pressure; aryl-, alkyl-, and heteroaryl-substituted imidazoles were obtained in high yields within 2 min under superheating conditions.

A green way to synthesize allyl phenols has been developed. Quantitative yield of 2-allyl-4-methoxyphenol was obtained via a fast Claisen rearrangement in a microreactor system without solvent and work-up.

Three homochiral metal–organic frameworks (MOFs) based on enantiopure chiral ligand: (R)-2,2’-dimethoxy-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-3,3′-dicarboxylic acid (H2L), namely Cd(L)(Py)31, Cu(L)(Py)32, Na[Cd(L)(LH)] · 2.5H2O 3 (Py = pyridine), were firstly synthesized, under solvothermal reactions. X-ray single-crystal diffraction studies reveal that 1 and 2 adopt one-dimensional (1D) infinite helical structures, while 3 possesses 2D chiral framework structure adopting ABAB offset stacking modes along the a-axis. Thermogravimetric analyses (TGA) display that 3 is thermally stable to 330 °C which is rare for homochiral MOFs.Three homochiral metal–organic frameworks are obtained using enantiopure octahydrobinaphthyl-derived dicarboxylic acid as bridging ligands and transition metal ions. Two polymeric motifs were observed in these compounds: the one-dimensional infinite chiral helical structure and the two-dimensional rhombic grids network.