Fengting Lv

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Name: 吕凤婷

Organization: Chinese Academy of Sciences , China

Department: Institute of Chemistry

Title: Associate Researcher/Associate Professor(PhD)

Chemicals
References

Efficient Conjugated Polymer–Methyl Viologen Electron Transfer System for Controlled Photo-Driven Hydrogen Evolution

Co-reporter:Huan Lu, Rong Hu, Haotian Bai, Hui Chen, Fengting Lv, Libing Liu, Shu Wang, and He Tian

ACS Applied Materials & Interfaces March 29, 2017 Volume 9(Issue 12) pp:10355-10355

Publication Date(Web):March 13, 2017

DOI:10.1021/acsami.7b00069

Photodriven hydrogen production has been a good strategy in solar energy utilization. In this work, we use a water-soluble negatively charged polythiophene derivative as photosensitizer to produce hydrogen from aqueous solution containing methyl viologen (MV2+), ethylenediaminetetraacetic acid disodium salt (EDTA), and a colloidal platinum catalyst upon exposure to xenon lamp (>420 nm) or natural sunlight. The supramolecular assembly and dis-assembly processes of MV2+ and cucurbit[8]uril (CB[8]) was further used to reversibly “turn-on” and “turn-off” hydrogen generation of the polymer system. This research offers a proof-of-concept to control hydrogen generation in demand, which is an advantage for hydrogen utilization and storage.Keywords: conjugated polymers; hydrogen generation; light catalysis; self-assembly; switch;

Polythiophene–Peptide Biohybrid Assemblies for Enhancing Photoinduced Hydrogen Evolution

Co-reporter:Huan Lu;Chengcheng Zhou;Xin Zhou;Han Sun;Haotian Bai;Yunxia Wang;Libing Liu;Yuguo Ma;Shu Wang

Advanced Electronic Materials 2017 Volume 3(Issue 11) pp:

Publication Date(Web):2017/11/01

DOI:10.1002/aelm.201700161

AbstractThe self-assembly of short peptide offers versatile processes for adjusting the ordered stacking of organic functional materials to enhance photoinduced electron transfer. Herein, this study presents the first demonstration of the use of Aβ16–22 peptide to prepare polythiophene/Aβ16–22 assemblies for a photocatalytic water splitting system. Isothermal titration microcalorimetry results show that the driving forces for polythiophene/Aβ16–22 assembly formation are electrostatic interactions, as well as hydrogen bonds and hydrophobic interactions. The assemblies accelerate the photoinduced electrons transfer from polythiophene upon light excitation and eventually enhance the hydrogen evolution. This work opens a new way into the development of biohybrid materials as novel photocatalytic water splitting platform for hydrogen evolution.

Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity

Co-reporter:Haotian Bai, Hongyi Zhang, Rong Hu, Hui Chen, Fengting Lv, Libing Liu, and Shu Wang

Langmuir 2017 Volume 33(Issue 4) pp:

Publication Date(Web):January 6, 2017

DOI:10.1021/acs.langmuir.6b04469

Infections of antibiotic-resistant pathogens have caused a series of public health crises across the world. According to the latest published reports, an antibiotic switch has been recognized as a potential strategy to control antibacterial activity for combating this serious drug resistance. Thus, it is anticipated that more effective antibiotic switches should be obtained by further exploring the developed strategies. Here, we report an improved pretreatment strategy using a surfactant (Triton X-100) for constructing an effective supramolecular antibiotic switch based on a poly(fluorene-co-phenylene) derivative (PFP) and cucurbit[7]uril (CB[7]), which can regulate the aggregation state of polymers before the supramolecular self-assembly process occurs. Triton X-100 can regulate the aggregation states of conjugated polymers, which is used to successfully realize the reversible control of bactericidal activity of PFP in the dark and under white light irradiation by supramolecular assembly/disassembly between PFP and CB[7]. Specialized antibiotic switches are significantly important to fight pathogenic infections and solve the drug resistance crisis in the future.

Preparation of Reactive Oligo(p-Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments

Co-reporter:Chenyao Nie;Shengliang Li;Bing Wang;Libing Liu;Rong Hu;Hui Chen;Zhihui Dai;Shu Wang

Advanced Materials 2016 Volume 28( Issue 19) pp:3749-3754

Publication Date(Web):

DOI:10.1002/adma.201600106

Supramolecular Conjugated Polymer Materials for in Situ Pathogen Detection

Co-reporter:Haotian Bai, Hui Chen, Rong Hu, Meng Li, Fengting Lv, Libing Liu, and Shu Wang

ACS Applied Materials & Interfaces 2016 Volume 8(Issue 46) pp:31550

Publication Date(Web):October 27, 2016

DOI:10.1021/acsami.6b09807

Cationic poly(fluorene-co-phenylene) derivative (PFP-NMe3+) forms a supramolecular complex with cucurbit[7]uril (CB[7]), which could be reversibly disassembled by amantadine (AD) to release PFP-NMe3+ due to the formation of more stable CB[7]/AD complex. The cationic PFP-NMe3+ is an amphiphilic structure and could bind to negatively charged membrane of pathogen by multivalent interactions. Upon the formation of PFP-NMe3+/CB[7] complex, the CB[7] could bury the side-chain alkyl groups and decreases the hydrophobic interactions of PFP-NMe3+ on the surface of pathogens; thus, PFP-NMe3+ exhibits different interaction modes with pathogens before and after assembly with CB[7]. The PFP-NMe3+/CB[7] supramolecular complex could be explored as optical sensor for simple, rapid, and in situ detection and discrimination of multiple pathogens by taking advantage of optical signal changes of PFP-NMe3+/CB[7] complex before and after disassembly by AD on the pathogen surfaces. The new sensor can realize in situ detection and identification of Gram-negative bacteria (E. coli, P. aeruginosa), Gram-positive bacteria (B. subtilis, S. aureus, E. faecalis), and the fungi (C. albicans, S. cerecisiae) and can also discriminate different strains of the same species. Blend samples of these pathogens could be identified successfully as well. In comparison with conventional blood culture-based pathogen assay methods that require at least for 24 h, the PFP-NMe3+/CB[7] complex only needs 2 h (including pathogen culture, pathogen harvest by centrifuging, and optical assay procedures) to stratify diverse pathogen types and also does not require specific biomarkers or cell labeling.Keywords: conjugated polymer; detection; microorganisms; sensor; supramolecular materials

Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability

Co-reporter:Hui Chen, Bing Wang, Jiangyan Zhang, Chenyao Nie, Fengting Lv, Libing Liu and Shu Wang

Chemical Communications 2015 vol. 51(Issue 19) pp:4036-4039

Publication Date(Web):22 Jan 2015

DOI:10.1039/C4CC09729G

A new method was developed through an efficient Förster resonance energy transfer (FRET) from guanidinium-pendant oligofluorene to green fluorescent protein (GFP) for specifically screening membrane-disrupting antibiotics to which bacteria have difficulty developing resistance.

A Supramolecular Antibiotic Switch for Antibacterial Regulation

Co-reporter:Haotian Bai;Huanxiang Yuan;Chenyao Nie;Bing Wang; Fengting Lv; Libing Liu ; Shu Wang

Angewandte Chemie International Edition 2015 Volume 54( Issue 45) pp:13208-13213

Publication Date(Web):

DOI:10.1002/anie.201504566

Abstract

A supramolecular antibiotic switch is described that can reversibly “turn-on” and “turn-off” its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.

A Supramolecular Antibiotic Switch for Antibacterial Regulation

Co-reporter:Haotian Bai;Huanxiang Yuan;Chenyao Nie;Bing Wang; Fengting Lv; Libing Liu ; Shu Wang

Angewandte Chemie 2015 Volume 127( Issue 45) pp:13406-13411

Publication Date(Web):

DOI:10.1002/ange.201504566

Abstract

Conjugated-Polymer-Based Energy-Transfer Systems for Antimicrobial and Anticancer Applications

Co-reporter:Huanxiang Yuan;Bing Wang;Libing Liu ;Shu Wang

Advanced Materials 2014 Volume 26( Issue 40) pp:6978-6982

Publication Date(Web):

DOI:10.1002/adma.201400379

Conjugated polymers (CPs) attract a lot of attention in sensing, imaging, and biomedical applications because of recent achievements that are highlighted in this Research News article. A brief review of recent progress in the application of CP-based energy-transfer systems in antimicrobial and anticancer treatments is provided. The transfer of excitation energy from CPs to photosensitizers leads to the generation of reactive oxygen species (ROS) that are able to efficiently kill pathogenic microorganisms and cancer cells in the surroundings. Both fluorescence resonance energy transfer (FRET) and bioluminescence energy transfer (BRET) modes are discussed.

Logic-signal output of fluorescent proteins for screening antibiotic combinations

Co-reporter:FengTing Lv;LiBing Liu;Shu Wang

Science China Chemistry 2014 Volume 57( Issue 12) pp:1696-1702

Publication Date(Web):2014 December

DOI:10.1007/s11426-014-5224-6

A new method to screen antibiotic combinations is demonstrated, which takes advantage of the logic-signal output of genetically engineered drug-resistant E. coli strains expressing different fluorescent proteins. Thirty-six antibiotic combinations for nine antibiotics were investigated. The operation of different logic gates can reveal the susceptibility, resistance, or synergistic effect of the antibiotic combinations in a rapid (7–8 h versus 24–28 h for typical growth-based assays), simple, quantitative and high-throughput manner. This logic-signal-based output patterns provide the basis for novel and reliable screening of antibiotic combinations and help us to both gain insight into the mechanisms of multi-drug action.

Synthesis of a New Conjugated Polymer for DNA Alkylation and Gene Regulation

Co-reporter:Chenyao Nie, Chunlei Zhu, Liheng Feng, Fengting Lv, Libing Liu, and Shu Wang

ACS Applied Materials & Interfaces 2013 Volume 5(Issue 11) pp:4549

Publication Date(Web):April 2, 2013

DOI:10.1021/am4001985

A new polyfluorene derivative containing pendent alkylating chlorambucil (PFP-Cbl) was synthesized and characterized. Under direct incubation with DNA in vitro, PFP-Cbl could undergo an efficient DNA alkylating reaction and induce DNA cross-linking. In vitro transcription and translation experiment exhibited that the PFP-Cbl significantly down-regulated the gene expression of luciferase reporter plasmid. The down-regulation of gene expression was also verified through the transfection experiment of p-EGFP plasmid, which showed decreased green fluorescent protein (GFP) in cells. Meanwhile, the self-luminous property of PFP-Cbl could make it able to trace the internalized PFP-Cbl and plasmid complexes resulted from cross-linking in cells by fluorescent microscopy. Combining the features of alkylating function, multivalent binding sites, and fluorescent characteristics, PFP-Cbl provides a new insight in the area of gene regulation and extends the new applications of conjugated polymers (CPs).Keywords: conjugated polymers; DNA alkylation; gene regulation; GFP; plasmid; protein expression;

Multiplex Detection of DNA Mutations by the Fluorescence Fingerprint Spectrum Technique

Co-reporter:Jinzhao Song;Jiangyan Zhang;Dr. Fengting Lv;Dr. Yongqiang Cheng;Bing Wang;Dr. Liheng Feng;Dr. Libing Liu ; Shu Wang

Angewandte Chemie International Edition 2013 Volume 52( Issue 49) pp:13020-13023

Publication Date(Web):

DOI:10.1002/anie.201305461

Protein-assisted conjugated polymer microarray: Fabrication and sensing applications

Co-reporter:FengTing Lü;XuLi Feng;LiBing Liu;Shu Wang

Science Bulletin 2013 Volume 58( Issue 33) pp:4039-4044

Publication Date(Web):2013 November

DOI:10.1007/s11434-013-6025-6

A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this work. The water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm, which makes it compatible with a variety of commercial microarray scanners. It is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without protein. The conjugated polymer microarray can be used for sensitive detection of picric acid (PA). A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray substrate. Considering the simplicity of the preparation of the conjugated polymer microarray, it is anticipated that novel sensing platforms will be constructed by employing this versatile method.

Multiplex Detection of DNA Mutations by the Fluorescence Fingerprint Spectrum Technique

Co-reporter:Jinzhao Song;Jiangyan Zhang;Dr. Fengting Lv;Dr. Yongqiang Cheng;Bing Wang;Dr. Liheng Feng;Dr. Libing Liu ; Shu Wang

Angewandte Chemie 2013 Volume 125( Issue 49) pp:13258-13261

Publication Date(Web):

DOI:10.1002/ange.201305461

Aptamer-based polymerase chain reaction for ultrasensitive cell detection

Co-reporter:Jinzhao Song, Fengting Lv, Gaomai Yang, Libing Liu, Qiong Yang and Shu Wang

Chemical Communications 2012 vol. 48(Issue 60) pp:7465-7467

Publication Date(Web):12 Jun 2012

DOI:10.1039/C2CC32085A

A new system was developed for sensitive and selective detection of tumor cells taking advantage of cell-attached aptamers amplified by PCR and output signals amplified by cationic conjugated polymers.

Multifunctional Non-Viral Delivery Systems Based on Conjugated Polymers

Co-reporter:Gaomai Yang;Bing Wang;Libing Liu;Qiong Yang ;Shu Wang

Macromolecular Bioscience 2012 Volume 12( Issue 12) pp:1600-1614

Publication Date(Web):

DOI:10.1002/mabi.201200267

Aptamer-based polymerase chain reaction for ultrasensitive cell detection

Co-reporter:Jinzhao Song, Fengting Lv, Gaomai Yang, Libing Liu, Qiong Yang and Shu Wang

Chemical Communications 2012 - vol. 48(Issue 60) pp:NaN7467-7467

Publication Date(Web):2012/06/12

DOI:10.1039/C2CC32085A

Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability

Co-reporter:Hui Chen, Bing Wang, Jiangyan Zhang, Chenyao Nie, Fengting Lv, Libing Liu and Shu Wang