23284-33-5|1-Pentanaminium,5-amino-5-carboxy-N,N,N-trimethyl-, inner salt, (5S)-

Collect

BASIC PARAMETERS Find an error

CAS: 23284-33-5

MF: C9H20N2O2

MW: 188.2673

Synonyms: 1-Pentanaminium,5-amino-5-carboxy-N,N,N-trimethyl-, inner salt, (5S)-

Supply Source

I can Supply this

REPORT BY

Wenshe R. Liu

Texas A&M University

follow

A Facile Method to Synthesize Histones with Posttranslational Modification Mimics

Co-reporter: Zhiyong U. Wang, Yane-Shih Wang, Pei-Jing Pai, William K. Russell, David H. Russell, and Wenshe R. Liu

pp:

Publication Date(Web):June 14, 2012

DOI: 10.1021/bi300535a

Using an evolved pyrrolysyl-tRNA synthetase-tRNAPyl pair, a Se-alkylselenocysteine was genetically incorporated into histone H3 with a high protein expression yield. Quantitative oxidative elimination of Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophiles generated biologically active mimics of H3 with posttranslational modifications including lysine methylation, lysine acetylation, and serine phosphorylation.