173206-13-8|4,5-dichloro-2-(tetrahydro-2h-pyran-2-yl)-3(2h)-pyridazinone

REPORT BY

Chen Ma

Shandong University

follow

An efficient C–C bond formation reaction for the synthesis of α-arylated ketones under mild conditions

Co-reporter: Yanli Liu, Xinhai Zhang, Ying Ma, Chen Ma

pp: 402-405

Publication Date(Web):30 January 2013

DOI: 10.1016/j.tetlet.2012.11.024

A wide range of substituted α-arylated ketones were synthesized in moderate to excellent yields via a Truce Smiles rearrangement. The main scaffold has various applications in medical and biochemical fields. This process also provides a facile and direct method for the C–C bond formation. Image for unlabelled figure

A facile method for the synthesis of pyridazino[4,5-b][1,4]thiazine-diones via Smiles rearrangement

Co-reporter: Yongmei Zhao, Yongcheng Bai, Qihui Zhang, Zhi Chen, Qiaoling Dai, Chen Ma

pp: 3253-3255

Publication Date(Web):19 June 2013

DOI: 10.1016/j.tetlet.2013.04.026

An efficient one-pot tandem method for the synthesis of pyridazino[4,5-b][1,4]thiazine-diones via Smiles rearrangement was developed. A number of ideal products were obtained with high yields without any byproducts. More specifically, this transition metal-free process is an environmentally friendly, economical, and efficient method for preparation of mixture-based heterocyclic libraries. Image for unlabelled figure

Zhi Chen

University of Jinan

follow