A pair of enantiopure cubane-type Cu^II₄O₄ clusters was constructed from simple chiral ligands (R or S)-2-[(2-hydroxy-1-phenylethylimino)methyl]phenol (H₂L^{R or S}). Single-crystal X-ray diffraction studies demonstrated that complexes 1R and 1S are enantiomers. They consist of a Cu^II₄O₄ cubane core in which the four Cu^II centres are linked by a μ₃-oxo bridge. The four Cu^II ions in one cluster are all in a distorted square-pyramidal geometry. Circular dichroism (CD) spectroscopy also confirmed that complexes 1R and 1S are enantiomers and that the chirality was successfully transferred and amplified from the ligand to the coordination environment of the Cu^II ions. Magnetic susceptibility measurements show an overall antiferromagnetic interaction which could be fitted by using MAGPACK with a two parameter model (J₁ = –5.58 cm^–1, J₂ = 3.80 cm^–1).